Dr James D'Rozario

Staff Specialist Canberra Hospital
Senior Lecturer

Dr D’Rozario is a consultant Haematologist and head of the Department of Haematology at Canberra Hospital. He is involved in projects focussed on the elucidation of genetic basis and cellular mechanisms of primary human leukaemic and lymphoma diseases. Techniques will include next generation sequencing, cloning and gene expression, flow cytometry and tissue culture. These projects will enable students to be at the interface between basic and clinical research, and would particularly be relevant to trainee haematologists interested in being actively involved in programs of basic research.

Research interests

  • Genetic and cellular basis of human leukaemia and lymphoma
  • Cancer Biology
  • Cancer Therapeutics
  • Transcription

1.Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis. Fletcher AL, Elman JS, Astarita J, Murray R, Saeidi N, D'Rozario J, Knoblich K, Brown FD, Schildberg FA, Nieves JM, Heng TS, Boyd RL, Turley SJ, Parekkadan B. Sci Transl Med. 2014 Aug 13;6(249):249ra109.

2.Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia. Cummins KD, Jane SM, Ninkovic S, Bazargan A, Filshie R, Sutrave G, Hertzberg M, Scott A, Lane S, Yannakou CK, Ritchie D, D'Rozario J, Black J, Bavishi K, Wei A. Blood Cancer J. 2014 Aug 8;4:e237.

3.Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span. Yabas M, Coupland LA, Cromer D, Winterberg M, Teoh NC, D'Rozario J, Kirk K, Bröer S, Parish CR, Enders A. J Biol Chem. 2014 Jul 11;289(28):19531-7.

4. An imatinib-only window followed by imatinib and chemotherapy for Philadelphia chromosome-positive acute leukemia: long-term results of the CMLALL1 trial.Lickliter JD, Taylor K, Szer J, Grigg A, Arthur C, Hughes TP, Durrant S, Filshie R, Irving I, Seldon M, Ellacott J, Boyd AW, D'Rozario J, Rooney K, Lynch K, Bradstock K; Australasian Leukaemia and Lymphoma Group. Leuk Lymphoma. 2015 Mar;56(3):630-8.

5.Pre infusion, post thaw CD34+ peripheral blood stem cell enumeration as a predictor of haematopoietic engraftment in autologous haematopoietic cell transplantation. D'Rozario J, Parisotto R, Stapleton J, Gidley A, Owen D. Transfus Apher Sci. 2014 Jun;50(3):443-50. doi: 10.1016/j.transci.2014.02.021.

6.Two rare cases of Epstein-Barr virus-associated lymphoproliferative disorders in inflammatory bowel disease patients on thiopurines and other immunosuppressive medications. Subramaniam K, Cherian M, Jain S, Latimer M, Corbett M, D'Rozario J, Pavli P. Intern Med J. 2013 Dec;43(12):1339-42. doi: 10.1111/imj.12287.

7.Lymphoma and other lymphoproliferative disorders in inflammatory bowel disease: a review. Subramaniam K, D'Rozario J, Pavli P. J Gastroenterol Hepatol. 2013 Jan;28(1):24-30. doi: 10.1111/jgh.12015..

8.Results of the APML3 trial incorporating all-trans-retinoic acid and idarubicin in both induction and consolidation as initial therapy for patients with acute promyelocytic leukemia. Iland H, Bradstock K, Seymour J, Hertzberg M, Grigg A, Taylor K, Catalano J, Cannell P, Horvath N, Deveridge S, Browett P, Brighton T, Chong L, Springall F, Ayling J, Catalano A, Supple S, Collins M, Di Iulio J, Reynolds J; Australasian Leukaemia and Lymphoma Group. Haematologica. 2012 Feb;97(2):227-34. doi: 10.3324/haematol.2011.047506. PMID: 21993673

9.Reversible posterior encephalopathy syndrome associated with bortezomib. Terwiel E, Hanrahan R, Lueck C, D'Rozario J. Intern Med J. 2010 Jan;40(1):69-71.

10.Acute interstitial nephritis secondary to deferasirox causing acute renal injury needing short-term dialysis. Yew CT, Talaulikar GS, Falk MC, Clayton P, D'Rozario J, Brown M. Nephrology (Carlton). 2010 Apr;15(3):377.

11.A multicenter phase 2 study of risk-adjusted salvage chemotherapy incorporating vinorelbine and gemcitabine for relapsed and refractory lymphoma. Pasricha SR, Grigg A, Catalano J, Leahy M, Underhill C, Arthur C, D'Rozario J, Lowenthal R, Reed K, Spencer A. Cancer. 2008 Dec 1;113(11):3192-8.

12. A variant chronic B-cell lymphoma characterized by villous cells with novel immunophenotypic and cytogenetic profiles. Coupland LA, Brun M, Jammu V, D'Rozario JM. Leuk Lymphoma. 2006 Jan;47(1):129-34.

13. Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood. Scolyer RA, Brun M, D'Rozario J, Webb M. Pathology. 2000 Feb;32(1):52-5.

14.Case report: gastrointestinal haemorrhage from jejunal diverticulosis, probably induced by low dose aspirin. Kaushik SP, D'Rozario JM, Chong G, Bassett ML. J Gastroenterol Hepatol. 1996 Oct;11(10):908-10.