Structure and function of the ryanodine receptor - mechanisms of human disease

About the Speaker

Andrew R. Marks, MD, received his undergraduate degree from Amherst College where he was the first student in the history of the college to graduate with honors in two subjects (Biology and English), and his MD from Harvard Medical School in 1980. Following an internship and residency in internal medicine at the Massachusetts General Hospital (MGH), he was a post-doctoral fellow in molecular genetics at Harvard Medical School, and then a clinical cardiology fellow at the MGH. 

He then moved back to his hometown, New York, in 1990, as an Assistant Professor of Molecular Biology and Medicine at Mount Sinai School of Medicine. In 1995 he was named the Fishberg Professor of Medicine at Mount Sinai, and in 1997 he moved to Columbia University College of Physician & Surgeons as Director of the Center for Molecular Cardiology and the Clyde and Helen Wu Professor of Medicine and Pharmacology. In 2003 Dr. Marks was appointed Chair and Professor of the Physiology and Cellular Biophysics Department at Columbia University.

Dr. Marks’ work on the mechanisms of action of drugs that inhibit vascular smooth muscle proliferation and migration has been translated into novel therapeutics including drug-eluting stents for treatment of coronary artery disease that have substantially reduced the incidence of in-stent restenosis, as well as effective therapy to reduce accelerated arteriopathy following cardiac transplantation. Dr. Marks has defined how macromolecular signaling complexes regulate ion channel function in muscle and non-muscle systems. His work has contributed new understandings of fundamental mechanisms that regulate muscle contraction.