Immune Mechanisms in Allergy

The focus of Dr Simon Hogan's scientific work has been to develop and employ new in vivo model approaches to investigate the contribution of immune cells and molecules to epithelial homeostasis and respiratory and gastrointestinal function in health and disease, particularly in allergic disorders such as eosinophilic gastrointestinal diseases (EGID) and food allergy and host defense.

Dr. Hogan completed his doctoral research training at the John Curtin School of Medical Research Australian National University with Professor Paul Foster PhD, focusing on cytokine regulation of allergic inflammation in the respiratory tract. Following receipt of a NHMRC CJ Martin Traveling Fellowship, he undertook his post-doctoral fellowship training at the Cincinnati Children’s Hospital with Professor Marc Rothenberg MD PhD studying the role of eosinophils in eosinophil-associated gastrointestinal diseases (EGIDs). Dr. Hogan joined the faculty at Cincinnati Children’s in 2004 where he developed a NIH-funded research program focused on delineating interactions at the immune- gastrointestinal epithelial interface under homeostasis and how alterations in these interactions can predispose to and modulate food-induced anaphylactic reactions. Dr. Hogan moved to University of Michigan and became the Askwith Research Professor of Food Allergy, Research Professor of Mary H Weiser Food Allergy Center Professor of Pathology, Michigan Medicine, University of Michigan in 2018.  Dr. Hogan has developed a research program focused on dissecting the pathways that regulate innate and adaptive immune cell function at barrier surfaces in the context of health and disease.  His research program also encompasses a significant effort to translate research findings in pre-clinical models into patient-based studies of immune-mediated diseases such as Food Allergy and Anaphylaxis. Dr. Hogan’s research is support by NIH, FARE and Mary H Weiser Food Allergy Center.