Illuminating the dark genome: Bringing insights in gene function to genomic medicine

Genetic research tends to focus on a minority of known, well-characterised genes, leaving most of the human and mouse genomes 'dark', with limited biological information available for the majority of genes. Investigation of unexplored genes is likely to open up novel, fundamental insights in biology and diseases. Thus, a major challenge for biomedical sciences is to build a comprehensive understanding of mammalian gene function that illuminates the dark genome. Such knowledge will be essential to support and inform studies of common and rare diseases and to advance genomic medicine.
The International Mouse Phenotyping Consortium (IMPC) is building a catalogue of mammalian gene function by generating and phenotyping a knock-out mouse line for every protein-coding gene. Professor Brown will present the latest progress and discoveries of the IMPC. The new genetic disease models and knowledge that have emerged from the work of the IMPC provide a more profound understanding of the function of human genetic variation and its impact on disease. This lays the foundation for new therapeutic opportunities and improved healthcare.

Professor Steve Brown works at MRC Harvell Institute, Harvell, UK. His research interests cover mouse functional genomics, including the use of large-scale mouse mutagenesis and comparative genomic analysis to study the genetic basis of disease and to develop pre-clinical disease models. A particular focus of Steve's work has been the use of mouse models to study the molecular basis of genetic deafness.

This event is free and open to the public. Refreshments will be served following the lecture.