Fantastic Voyage - Imaging leukocyte function in inflammatory disease

Professor Michael Hickey, NHMRC Senior Research Fellow, Centre for Inflammatory Diseases, Monash University

This seminar will examine elements of our recent work examining a novel form of lymphocyte activation occurring in the glomerular capillaries in the kidney in a model of CD4+ T cell-mediated glomerular inflammation; and trafficking and behaviour of regulatory T cells in resting and inflamed skin. It will highlight the use of intravital imaging to reveal new information on the behaviour of particular immune cell subsets in vivo.

Michael Hickey is a National Health & Medical Research Council (NHMRC) Senior Research Fellow and Deputy Director of the Monash University Centre for Inflammatory Diseases at Monash Medical Centre. He received his PhD from the University of Melbourne in 1996, and undertook postdoctoral training at the University of Calgary. His expertise lies in the analysis of the actions of leukocytes during inflammatory responses. His laboratory uses various forms of advanced in vivo imaging, including multiphoton microscopy, to image a wide range of tissues during the inflammatory response. This approach is used to investigate leukocyte-endothelial cell interactions and other leukocyte behaviours in the inflamed kidney, skin and muscle. His work has been published in journals such as Nature Medicine, Nature Communications and Proc. Natl. Acad. Sci. USA.