Atomic resolution cryo-EM structures of mammalian pore forming immune effectors

Professor James Whisstock, Director of the ARC Centre of Excellence in Advanced Molecular Imaging, Monash Biomedicine Discovery Institute, Monash University, Melbourne.

James Whisstock performed his PhD in bioinformatics and structural biology at the University of Cambridge. In 1997 he moved to Australia and established his group at Monash University. James is currently an NHMRC Senior Principal Research Fellow, he is the Scientific Director of the ARC Centre of Excellence in Advanced Molecular Imaging and he is the Scientific Head of EMBL Australia.  His previous appointments include an ARC Federation Fellowship. James was awarded the 2006 Science Ministers prize, the 2008 Health ministers prize and the 2010 Gottschalk medal. James's current research directions include understanding the structure and function of pore forming proteins in immunity and Drosophila development. His team further investigates the proteolytic cascades that control blood coagulation and wound remodelling.

Over the course of his career at Monash, James has led the development of several key technology platforms, including protein production, eResearch and protein crystallography. Most recently he led the initiative to establish Australia's first automated state-of-the-art Electron Microscopy unit.