Most of the human genome remains "dark", with little biological information available for the majority of genes. Investigating the dark genome is essential to advance knowledge and better understand diseases. Professor Steve Brown will present the last discoveries made by the International Mouse Phenotyping Consortium.
Autoimmune diseases arise when our immune cells turn against our own tissues and cells, damaging or destroying them. There are over different 80 autoimmune diseases affecting 3-5% of the population, and no cures. To develop better treatmens, we must understand the molecular and genetic causes of these diseases.
Dr Quinn’s group conducts discovery-driven fundamental research using Drosophila (Vinegar fly) genetics to provide the new insights into cancer initiation and progression, which are essential to uncover new therapeutic avenues to improve patient outcomes.
Our research shows that this is likely to lie within the insulin producing cells of the pancreas, or "the islet beta-cells of Langerhans.” Furthermore, the suspect pathway can be targeted by novel therapies.