Understanding how host genes affect anti-viral immunity

Through collaborations with Professors Chris Goodnow and Matthew Cook, we are identifying genes that may have unstudied roles in anti-viral immunity. These genes are identified either through screening of mice exposed to a chemical mutagen (Goodnow), or through genome sequencing of patients with immunodeficiencies (Cook). Once genes of interest are found we examine how changes in or loss of these affects antiviral immunity in our mouse models of herpes simplex virus infection or vaccinia virus vaccination.

Image: Localisation of vaccinia virus protein F5 in finger like projections between two infected cells.

Partnerships

Professor Chris Goodnow, JCSMR and Garvan Institute

Professor Matt Cook, JCSMR, ANU Medical School and The Canberra Hospital

Updated:  29 April 2017/Responsible Officer:  Director, JCSMR/Page Contact:  Web Manager