Hospital acquired infections are caused by bacteria, viruses and fungi. These infections are strongly increasing in prevalence to 1 in 25 patients in Australia, Europe and USA. Over 700,000 patients in the US a year contract a hospital-acquired infection. Most of these hospital-acquired infections are caused by multi resistant bacteria to antibiotics “superbugs”. There are growing concerns due to the acquisition of multi resistance to antibiotics from the bacteria and the lack of novel antibiotics in the market. We are interested in understanding how the host can combat these multi-resistant bacteria and become resistant to these multidrug resistant bacteria and how the bacteria escape to the host immune system.