The Neuronal Integration Laboratory investigates the mechanisms that neurons use to integrate the many thousands of synaptic inputs they receive from other neurons. This process is called synaptic integration and ultimately leads to the generation of a nerve impulse or action potential. As most of the synaptic input from other neurons is made onto fine structures called dendrites one of the main areas of interest is the properties and function of the dendritic tree. We are currently investigating these issues using techniques such as patch-clamp recording, imaging and neuronal modeling both in vitro (using brain slices) and in vivo. We are also interested in investigating how the capacity for neurons to process information changes during learning and memory formation, and also under pathological conditions such as sensory deprivation and epilepsy.