Genetic identification of the host response to malaria

Malaria infection is the third lethal disease worldwide and a treatment is desperately needed. Malarial parasites have led to selected mutations showing an increase in the gene pool of human population living in endemic regions and these mutations render the human population more resistant to malaria. We are interested in understanding the mechanisms of resistance from the malaria parasite. In close collaboration with Professor Simon Foote and Associate Professor Brendan McMorran, we have performed a large-scale N-Ethyl-N-Nitrosourea (ENU) mutagenesis experiment in mice by mutating genes that confer resistance to the malaria parasite. We have identified over 40 genes conferring resistance to the malaria parasite. We are also interested in a better understanding of the interactions between the parasite and the host. We have developed a system to interrogate simultaneously the changes in the parasite and the host during the course of the infection and to survey the rapid adaptation of the parasite to the host. From the bench to clinics, we have developed a series of assays and a pre-clinical pipeline for any potential antimalarial drugs.

Updated:  24 September 2018/Responsible Officer:  Director, JCSMR/Page Contact:  Web Manager