Current research

Project name Group
Characterization of H2A.Lap1 KO mice spermatogenesis following heat stress or gamma irradiation. The Tremethick Group - Chromatin and transcriptional regulation during development
Elucidate the role of testis-specific histone variant expression in the Purkinje neurons of mouse cerebellum The Tremethick Group - Chromatin and transcriptional regulation during development
Gene regulation in human neutrophils from patients with systemic vasculitis The Cook Group - Translational Research
5-methylcytosine as an epitranscriptomic mark The Preiss Group - RNA Biology
670nm Red Light as a treatment for Retinopathy of Prematurity (Phase 1 Clinical Trial) The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
670nm Red Light as a treatment for Retinopathy of Prematurity (Phase 1 Clinical Trial) The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
A longitudinal study of depression, anxiety, substance use and cognitive change: PATH Through Life The Easteal Group - Genome Diversity & Health
A new paradigm for the control of cellular function: the dynamic reshaping of the epigenome by histone variants The Tremethick Group - Chromatin and transcriptional regulation during development
A novel mechanism of long-term memory formation that involves testis-specific histone variant expression in the brain The Tremethick Group - Chromatin and transcriptional regulation during development
A novel role for the pol I transcription factor UBF in the regulation of expression of histone gene clusters and cellular DNA damage responses The Hannan Group - Cancer Therapeutics
Abnormal brain development in a rat model of Hirschsprung's disease The Song Group
Application of Bayesian modelling of high-throughput genomic data to obtain robust and interpretable estimates of model parameters The Hannan Group - Cancer Therapeutics
B cell responses to malaria The Cockburn Group - Malaria Immunology
Biological validation of machine learning models for HBV infection and disease
Brain tumour models The Hannan Group - Cancer Therapeutics
Calcium imaging of presynaptic terminals The Stricker Group - Neuronal Networks
Cancer Stem Cell Models The Hannan Group - Cancer Therapeutics
CFS/ME Pathology in silico
Characterising mutation
Characterising the plasma cell compartment in Waldenstrom Macroglobulinaemia The Hannan Group - Cancer Therapeutics
Chromatin and RNA surveillance The Fischer Group - Epigenetics and Genomic Stability
Circuit mapping in the piriform cortex using optogenetics The Bekkers Group - Olfaction
Consequences of impaired neuronal activity during development in a mouse model of autism The Dehorter Group
Defining the biological role, regulation and signalling mechanism for IL-5 The Young Group - Cytokine Molecular Biology & Signalling
Determining synaptic properties in small networks of neurons The Stricker Group - Neuronal Networks
Developing new avenues for the treatment of Hodgkin lymphoma and other blood cancers The Tremethick Group - Chromatin and transcriptional regulation during development
Development of a molecular tool for personalised cancer treatment – a synthetic biology approach The Fischer Group - Epigenetics and Genomic Stability
Development of CRISPR/Cas9 genome editing technology The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
Development of novel drugs for the treatment of sepsis The Parish Group - Cancer & Vascular Biology
Developmental expression and role of a receptor involved in schizophrenia The Dehorter Group
Disease heterogeneity in NHL The Hannan Group - Cancer Therapeutics
Early signs of impaired neuronal activity in a mouse model of striatum-related pathology The Dehorter Group
Epilepsy and olfaction The Bekkers Group - Olfaction
Establish a robust and reproducible high-throughput data analysis workflow using snakemake The Hannan Group - Cancer Therapeutics
Evaluate B cell immunity to HIV vaccines The Ranasinghe Group - Molecular Mucosal Vaccine Immunology
Evaluate the quality of HIV-specific mucosal and systemic immunity following prime-boost vaccination The Ranasinghe Group - Molecular Mucosal Vaccine Immunology
Evaluate the role of IL-4/IL-13 at the vaccination site in the context of antigen presenting cells and innate lymphocytic cells The Ranasinghe Group - Molecular Mucosal Vaccine Immunology
Evaluate vaccine route specific immunity in relation to IL-4 and IL-13 The Ranasinghe Group - Molecular Mucosal Vaccine Immunology
Evaluation of the role of testis-specific histone variant H2A.Bbd in Hodgkin lymphoma and other cancers The Tremethick Group - Chromatin and transcriptional regulation during development
Evolution of behavioural, personality and cognitive diversity in humans The Easteal Group - Genome Diversity & Health
Evolution of vertebrate photoreceptors and the vertebrate retina The Lamb Group - Visual Neuroscience
Functional Ca imaging of odour responses in the piriform cortex The Bekkers Group - Olfaction
Gene regulation through interactions between RNA, enzymes and metabolites The Preiss Group - RNA Biology
Genetic and cellular basis of human immune deficiency The Cook Group - Translational Research
Genetic factors involved in breast cancer susceptibility in mice and humans The Blackburn Group - Cancer Metabolism & Genetics
Genetic identification of the host response to malaria The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
Genetics and Machine Learning The Arcos-Burgos Group
Genetics and Machine Learning The Arcos-Burgos Group
Genetics of the host response to multi-drug resistant bacteria or “superbugs” The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
Genome editing as a novel way to study the interactions between the host and pathogens The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
Genomic catastrophe and retrotransposons reactivation in breast cancer tissues
Glial modulation of neuronal activity The Billups Group - Synaptic Mechanisms
Glutamate recycling at presynaptic terminals The Billups Group - Synaptic Mechanisms
Harnessing the immune response against cancer The Parish Group - Cancer & Vascular Biology
Higher order image statistics and image texture The Maddess Group - Diagnostics for Eye Diseases
Host red enzymes as targets for host-directed antimalarial therapy The Foote Group - Genetics and Infectious Diseases
The McMorran Group - Genetics and Infectious Diseases
Host red enzymes as targets for host-directed antimalarial therapy The Foote Group - Genetics and Infectious Diseases
The McMorran Group - Genetics and Infectious Diseases
How IL-5, IL-3 and GM-CSF regulate blood cell growth and function The Young Group - Cytokine Molecular Biology & Signalling
Identification and analysis of platelet polymorphisms associated with malaria susceptibility The McMorran Group - Genetics and Infectious Diseases
The Foote Group - Genetics and Infectious Diseases
The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
Identification and analysis of platelet polymorphisms associated with malaria susceptibility The McMorran Group - Genetics and Infectious Diseases
The Foote Group - Genetics and Infectious Diseases
The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
Identification and analysis of platelet polymorphisms associated with malaria susceptibility The McMorran Group - Genetics and Infectious Diseases
The Foote Group - Genetics and Infectious Diseases
The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
Identify biomarkers to measure vaccine-specific mucosal immunity The Ranasinghe Group - Molecular Mucosal Vaccine Immunology
Identifying the causes of germline mutation The Easteal Group - Genome Diversity & Health
Identifying the genetic signatures of acquired resistance to Pol I transcription inhibitors in cancer The Hannan Group - Cancer Therapeutics
Immunodominance in CD8+ T cell responses to vaccinia virus The Tscharke Group - Viruses and Immunity
Inferring function
Investigating B and T lymphocytes The Parish Group - Cancer & Vascular Biology
Investigating how pertubations in ribosome biogenesis inhibit cellular growth The Hannan Group - Cancer Therapeutics
Investigating the role of heparan sulfate and heparanase in tumour metastasis, angiogenesis and inflammation The Parish Group - Cancer & Vascular Biology
Investigating the role of platelets in tumour metastasis The Parish Group - Cancer & Vascular Biology
Investigation of the functions of the mammalian homologues of Drosophila genes The Young Group - Cytokine Molecular Biology & Signalling
Leukemia Models The Hannan Group - Cancer Therapeutics
Mapping the functional evolution of three prion protein family genes The Gready Group - Computational & Conceptual Biology
Mathematical models of non-random features of synaptic transmission The Stricker Group - Neuronal Networks
Mechanisms regulating IL-5 gene expression in T lymphocytes The Young Group - Cytokine Molecular Biology & Signalling
Messenger RNA and noncoding RNA in cardiac biology The Preiss Group - RNA Biology
Migration, effector function and transcriptional regulation of Th17 The Bruestle Group - Inflammatory T Cell Responses
Modelling human primary immune deficiences in mice The Enders Group - Immunization Genomics
Modelling of presynaptic calcium dynamics during synaptic depression The Stricker Group - Neuronal Networks
Modelling of short-term synaptic plasticity at cortical synapses The Stricker Group - Neuronal Networks
Molecular Control of the Interneuron Integration and Synapse Formation The Dehorter Group
Molecular, cellular, and functional differences between rod and cone photoreceptors The Lamb Group - Visual Neuroscience
Monogenic human immune deficiency disease The Cook Group - Translational Research
Multifocal pupillographic objective perimetry The Maddess Group - Diagnostics for Eye Diseases
Multifocal visual evoked potentials The Maddess Group - Diagnostics for Eye Diseases
Mutations in ribosome biogenesis and MDS The Hannan Group - Cancer Therapeutics
Neural circuits for odour-processing in the rodent piriform cortex 'in vivo' The Bekkers Group - Olfaction
Neuronal and behavioural correlates of sensory adaptation The Arabzadeh Group - Neural Coding
Neuronal substrate of choice The Arabzadeh Group - Neural Coding
Neutrophils and their extracellular traps in MS pathology The Bruestle Group - Inflammatory T Cell Responses
The Parish Group - Cancer & Vascular Biology
Neutrophils and their extracellular traps in MS pathology The Bruestle Group - Inflammatory T Cell Responses
The Parish Group - Cancer & Vascular Biology
New avenues for early detection of cancer in Hodgkin Lymphoma patients who are likely to relapse under current treatment The Tremethick Group - Chromatin and transcriptional regulation during development
New technology to design mutants of the photosynthetic enzyme Rubisco The Gready Group - Computational & Conceptual Biology
NF-kB signalling in human inflammatory disease The Cook Group - Translational Research
Optimising the dose of 670nm light therapy for treatment of retinal degenerations The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
Optimising the dose of 670nm light therapy for treatment of retinal degenerations The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
Phospholipid transport and B cell development The Enders Group - Immunization Genomics
Platelet-based autoimmune diseases The Gardiner Group - Mechanisms of Thrombosis and Cancer
Platelet-tumour cell interactions and cancer-related thrombosis The Gardiner Group - Mechanisms of Thrombosis and Cancer
Platelets as an intravascular link in neurological diseases (eg Alzheimer’s Disease) The Gardiner Group - Mechanisms of Thrombosis and Cancer
Presymptomatic Signatures of Interneuron Dysfunction in Mice Models of Striatum-Related Pathologies The Dehorter Group
Projection of three-dimensional light fields for neurophotonics The Daria Group - Neurophotonics
Recovery from intense bleaching exposures: human photoreceptors, retinal bipolar cells, and the overall visual system The Lamb Group - Visual Neuroscience
Regulation of chromatin remodeling of the rRNA genes in mouse embryonic stem cells The Hannan Group - Cancer Therapeutics
Response recovery and adaptation in vertebrate photoreceptors The Lamb Group - Visual Neuroscience
RNA polymerase I inhibitors as therapeuitics for cancer: analysis of p53 -dependent and – independent cell cycle checkpoints The Hannan Group - Cancer Therapeutics
RNA polymerase I inhibitors as therapeuitics for cancer: Testing combination therapies for heamtologic malignancies The Hannan Group - Cancer Therapeutics
Role of a transcription factor involved in cell identity and function The Dehorter Group
Role of miRNA in retinal degeneration The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
Role of miRNA in retinal degeneration The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
Sensory coding mechanisms in rat somatosensory system The Arabzadeh Group - Neural Coding
Sensory integration in the whisker pathway The Arabzadeh Group - Neural Coding
Simulation of “in-silico” genomic high-throughput sequencing data to assess and benchmark results from different computational tools, and to guide parameter optimisation The Hannan Group - Cancer Therapeutics
Stem cell transplantation in treating cerebellar cell loss in Hirschsprung’s disease The Song Group
Studying histidine-rich glycoprotein (HRG) The Parish Group - Cancer & Vascular Biology
Studying the interaction between genes and environment in Indigenous Kidney Disease The Foote Group - Genetics and Infectious Diseases
The McMorran Group - Genetics and Infectious Diseases
The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
Studying the interaction between genes and environment in Indigenous Kidney Disease The Foote Group - Genetics and Infectious Diseases
The McMorran Group - Genetics and Infectious Diseases
The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
Studying the interaction between genes and environment in Indigenous Kidney Disease The Foote Group - Genetics and Infectious Diseases
The McMorran Group - Genetics and Infectious Diseases
The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions
T cell responses to malaria The Cockburn Group - Malaria Immunology
Technology and methodology development
Test novel mucosal vaccine adjuvants to enhance mucosal B and T cell immunity against mucosal pathogens The Ranasinghe Group - Molecular Mucosal Vaccine Immunology
Testing compounds that may have pro- or anti-angiogenic activities The Parish Group - Cancer & Vascular Biology
The development of low-dose IL-2 therapy for inflammatory and autoimmune diseases The Yu Group - T-cell Immune Mechanism, Monitoring and Modulation (TIM3)
The development of superagonist monoclonal antibodies to human IL-21 in immunotherapy for infection and cancer The Yu Group - T-cell Immune Mechanism, Monitoring and Modulation (TIM3)
The differentiation and function of follicular cytotoxic T (Tfc) cells in infection and cancer The Yu Group - T-cell Immune Mechanism, Monitoring and Modulation (TIM3)
The regulation of follicular helper T (Tfh) cells in vaccination and autoimmune diseases The Yu Group - T-cell Immune Mechanism, Monitoring and Modulation (TIM3)
The role of chromatin in the repression of pervasive transcription The Fischer Group - Epigenetics and Genomic Stability
The role of epigenetics factors in genomic instability
The role of IL-5 in allergic lung disease The Young Group - Cytokine Molecular Biology & Signalling
The role of oxidative stress in the progression of retinal degenerations The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
The role of oxidative stress in the progression of retinal degenerations The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
The role of pervasive transcription in genomic instability and how it contributes to cancer development The Fischer Group - Epigenetics and Genomic Stability
The role of platelets in the protection against malarial infection The Foote Group - Genetics and Infectious Diseases
The McMorran Group - Genetics and Infectious Diseases
The role of platelets in the protection against malarial infection The Foote Group - Genetics and Infectious Diseases
The McMorran Group - Genetics and Infectious Diseases
The spatial frequency doubling illusion The Maddess Group - Diagnostics for Eye Diseases
The special role of histone variants in regulating the inheritance and three-dimensional organisation of the epigenome The Tremethick Group - Chromatin and transcriptional regulation during development
The use of miRNA as potential therapeutic targets in diseases causing retinal degenerations The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
The use of miRNA as potential therapeutic targets in diseases causing retinal degenerations The Provis Group - Gene expression in the human macula
The Valter Group - Retinal Cell Damage and Repair
Tissue specific factors of Th17cell mediated autoimmunity The Bruestle Group - Inflammatory T Cell Responses
Tracking factor footprints to reveal the intricacy and control of translation initiation The Preiss Group - RNA Biology
Transcriptional control of the MYC oncogene The Hannan Group - Cancer Therapeutics
Treatment and prevention of cancer by targeting cancer cell metabolism with dichloroacetate. The Blackburn Group - Cancer Metabolism & Genetics
Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease The Tremethick Group - Chromatin and transcriptional regulation during development
Understand the IL-4/ IL-13 molecular mechanisms governing the induction of high avidity T and B cell immunity The Ranasinghe Group - Molecular Mucosal Vaccine Immunology
Understanding B cell development - The role of SPPL2A on B cell survival The Enders Group - Immunization Genomics
Understanding how host genes affect anti-viral immunity The Tscharke Group - Viruses and Immunity
Understandingthe function of a receptor in interneuron identity and plasticity The Dehorter Group
Use live animal imaging technologies to assess vaccine safety and uptake The Ranasinghe Group - Molecular Mucosal Vaccine Immunology
Use of L1 retrotransposon as a novel breast cancer biomarker
Viruses and Immunity The Tscharke Group - Viruses and Immunity
Why do live pathogens make better vaccines? The Cockburn Group - Malaria Immunology

Updated:  27 March 2017/Responsible Officer:  Director, JCSMR/Page Contact:  Web Manager