The Neuronal Signalling Group is interested in understanding how single neurons in the brain process information. The brain is made up of billions of neurons connected to each other in complex networks. The main objective of my group is to understand how individual neurons within these networks integrate the thousands of synaptic inputs they receive. While most synaptic input to neurons is made onto their dendrites, understanding the role of dendrites in information processing in the brain is a primary
focus of the group. In addition, we are interested in the role of single neurons in learning and memory formation, processing of binocular visual information and decision making. To address these issues we record from individual neurons in vitro and in vivo using both electrophysiological (patch-clamp) and imaging techniques (confocal and 2-photon), often combining experiments with modelling.
- Bock, T. and Stuart, G.J. (2016) Impact of calcium-activated potassium channels on NMDA spikes in cortical layer 5 pyramidal neurons. J. Neurophysiology 115: 1740–1748
- Stuart, G.J and Spruston, N. (2015) Dendritic integration: 60 years of progress. Nature Neuroscience 18, 1713-1721
- Go, M.A, To, M-S, Stricker, C, Redman, S, Bachor, H-A, Stuart, G.J. and Daria, V.R. (2013) Four-dimensional multi-site photolysis of caged neurotransmitters. Frontiers in Cellular Neuroscience 7:231, 1-9 (10.3389/fncel.2013.00231).
- Jones, S & Stuart, G 2013, 'Different calcium sources control somatic versus dendritic SK channel activation during action potentials', Journal of Neuroscience, vol. 33, no. 50, pp. 19396-19405