Associate Professor Elizabeth Gardiner is an NHMRC Senior Research Fellow in the ACRF Department of Cancer Biology and Therapeutics at The John Curtin School of Medical Research, ANU, Canberra, Australia. She has published more than 90 peer-reviewed research papers, commentaries and reviews in the area of platelet biochemistry and platelet function, particularly relevant to both thrombosis and bleeding in patients. She identified a novel mechanism for shedding of vascular receptors triggered by shear stress, enabling new capabilities in diagnostic and therapeutic reagent development.
She is co-chair of the International Society for Thrombosis and Haemostasis (ISTH) Scientific Subcommittee for Vascular Biology and a member of the 2016 ISTH Education Committee Working Group to develop the program and course template for the Clinical Core Curriculum for Vascular Biology and is a member of the Asian-Pacific Microangiopathic Thrombocytopenia (APMAT) Network steering committee. She is the immediate past Treasurer of the Australian Vascular Biology Society. She is a Principal Editor of the journal Platelets.
Since establishing her laboratory in JCSMR, ANU, Elizabeth has established the National Platelet Research and Referral Centre (NPRC) which seeks to improve our understanding of platelet disorders and identify the most effective treatment options through collaborative and targeted research approaches.
Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM. Receptor clustering as a mechanism to regulate GPVI signalling in platelets. J Thromb. Haemost. (2017) in press.
Trevillyan JM, Gardiner EE, Andrews RK, Maisa A, Hearps AC, Al-Tamimi M, Crowe SM and Hoy JF. Decreased levels of platelet derived soluble glycoprotein VI detected prior to first diagnosis of coronary artery disease in HIV positive patients. Platelets (2016) Early Online: 1–4
Andrews RK, Arthur JF and Gardiner EE. Targeting GPVI as a novel antithrombotic strategy J. Blood Med. (2014) 5: 59-68.
Gardiner EE and Andrews RK. Platelet receptor expression and shedding: GPIb-IX-V and GPVI. Transfus. Med. Rev. (2014) 28: 56-60.
Andrews RK, Arthur JF and Gardiner EE Neutrophil extracellular traps (NETs) and the role of platelets in infection. Thromb. Haemost. (2014) 112: 659-65.
Murphy DA, Hockings L, Andrews RK, Aubron C, Gardiner EE, Pellegrino V and Davis AK. Extracorporeal Membrane Oxygenation (ECMO) - Haemostatic Complications. Transfus. Med. Rev. (2015) 29: 90-101.
Andrews RK and Gardiner EE. Metalloproteolytic receptor shedding…platelets “acting their age”. Platelets (2016) In press.
Andrews RK and Gardiner EE. Basic mechanisms of platelet receptor shedding. Platelets (2016) In press.
Trist HM, Tan PS, Wines BD, Ramsland PA, Orlowski E, Stubbs J, Gardiner EE, Pietersz GA, Kent SJ, Stratov I, Burton DR and Hogarth PM. Polymorphisms and interspecies differences of the activating and inhibitory FcγRII of Macaca nemestrina influence the binding of human IgG subclasses. J. Immunol. (2014) 192: 792-803
Pennings GJ, Yong ASC, Wong C, Al-Tamimi M, Gardiner EE, Andrews RK, Kritharides L. Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma. Platelets (2014) 25: 639-642.
Lamrani L, Lacout C, Ollivier V, Denis CV, Gardiner EE, Noe BHT, Vainchenker W, Villeval J-L, Jandrot-Perrus M. Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm. Blood (2014) 124: 1136-45.
Au A, Sashindranath M, Borg R, Kleifeld O, Andrews RK, Gardiner EE, Medcalf RL and Samson A. Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase. Cell Death Dis (2014) 5: e1410 (15 pages)
Gitz, E, Pollitt AY, Gitz-Francois JJ, Alshehri O, Mori J, Montague S, Douglas MR, Gardiner EE, Andrews RK, Buckley CD, Harrison P and Watson SP. CLEC-2 expression is maintained on activated platelets and on platelet microparticles. Blood (2014) 124: 2262-70.
Flierl U, Nero TL, Lim B, Arthur JF, Yao J, Jung S, Gitz E, Pollitt AY, Jandrot-Perrus M, Schäfer A, Nieswandt B, Andrews RK, Parker MW, #Gardiner EE, #Peter K. Phosphorothioate oligonucleotides are potent platelet activators: A caveat for nucleotide-based drug development? J. Exp. Med. (2015) 212: 129-37. #Equal senior authors
Sánchez Guiu MI, Martínez-Martinez I, Martínez C, Navarro-Fernandez J, Garcia-Candel F, Ferrer-Marín F, Vicente V, Watson SP, Andrews RK, Gardiner EE, Lozano ML, Rivera J. An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets. Thromb. Haemost. (2015) 114: 15-25
Qiao J, Davis AK, Morel-Kopp MC, Ward CM, Gardiner EE and Andrews RK. Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ibβ in a patient with Bernard-Soulier syndrome. Ann Hematol (2015) 94: 2069-2071.
Carrim N, Arthur JF, Hamilton JR, Gardiner EE, Andrews RK, Moran N, Berndt MC and Metharom P. Thrombin-induced reactive oxygen species generation in platelets: a novel role for protease-activated receptor 4 and GPIba. Redox Biol. (2015) 6: 640-647.
Trevillyan JM, Arthur JF, Jing J, Andrews RK, Gardiner EE and Hoy JF. Effects of abacavir administration on structural and functional markers of platelet activation. AIDS (2015) 29: 2309-2313.
Pinar IP, Arthur JF, Andrews RK, Gardiner EE, Ryan K. and Carberry J. Methods to determine the Lagrangian shear experienced by platelets during thrombus growth. PLoS One (2015) 10: e0144860 (14 pages).
Muthiah K, Connor D, Ly K, Gardiner EE, Andrews RK, Qiao J, Rutgers D, Robson D, Low J, Jarvis S, Macdonald P, Dhital K, Jansz P, Joseph J and Hayward C. Longitudinal changes in haemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous flow left ventricular assist devices. J Heart Lung Transpl. (2016) 35: 743-751.
Facey A, Pinar IP, Arthur JF, Qiao J, Mado B, Carberry J, Andrews RK and Gardiner EE. A-disintegrin-and-metalloproteinase (ADAM) 10 activity on resting and activated platelets. Biochemistry (2016) 55: 1187-1194.
French SL, Arthur JF, Lee H, Andrews RK, Gardiner EE and Hamilton JR. Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood. J. Thromb. Haemost. (2016) 14: 1-13.
Healy LD, Itakura A, Chu T, Robinson DK, Bylund A, Phillips KG, Gardiner EE, McCarty OJT. Development of a platform to quantify the colocalization of neutrophil extracellular DNA and coagulation factors using immunofluorescence-based microscopy. J Immunol. Meth. (2016) 435: 77-84.
Ong DM, Aumann H, Andrews RK, Gardiner EE, Rodgers SE, Davis AK. M1761K mutation in the VWF A3 domain associated with impaired collagen binding and without platelet dysfunction. Haemophilia (2016) 22: e345-346.
Simone M. Schoenwaelder, Roxane Darbousset, Susan L. Cranmer, Hayley S. Ramshaw, Stephanie L. Orive, Sharelle Sturgeon, Yuping Yuan, YuYao, James R. Krycer, Joanna Woodcock, Jessica Maclean, Stuart Pitson, Zhaohua Zheng, Darren C. Henstridge, Dianne van der Wal, Elizabeth E. Gardiner, Michael C. Berndt, Robert K. Andrews, David E. James, Angel F. Lopez and Shaun P. Jackson (2016) 14-3-3z regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications 7:12862