Dr Yu came to Australia in 2003 to study Immunology with Professors Carola Vinuesa and Chris Goodnow at The Australian National University. He was awarded PhD in 2007 and subsequently carried out postdoctoral training with Professor Charles Mackay at the Garvan Institute of Medical Research, where he continued research on the differentiation and function of follicular helper T cells and also initiated new direction of translational research including cytokine-based immunotherapy. In 2011, he was selected as Monash Fellow to establish his research group of Molecular Immunomodulation at Monash University. He returns to the Australian National University in 2017 as Associate Professor to lead the lab of T-cell Immune Mechanism, Monitoring and Modulation (TIM3).
Dr Yu and his team are investigating the molecular mechanisms of T cells that regulate the competence and the balance of immune responses, with the aim to design new strategies to modulate the immune system to treat autoimmune disease, infection and cancer. His research is published in journals including Nature, Nature Immunology, Nature Medicine and Immunity. He is a recipient of the New Investigator Award from the Australasian Society for Immunology (ASI), and the International Research Award from the Australian Society for Medical Research (ASMR), the Excellence Award from the Australian National Health and Medical Research Council (NHMRC) and The Milstein Young Investigator Award from The International Cytokine and Interferon Society (ICIS).
Leong YA, Chen Y, Ong HS, Wu D, Man K, Deleage C, Minnich M, Meckiff BJ, Wei Y, Hou Z, Zotos D, Fenix KA, Atnerkar A, Preston S, Chipman JG, Beilman GJ, Allison CC, Sun L, Wang P, Xu J, Toe JG, Lu HK, Tao Y, Palendira U, Dent AL, Landay AL, Pellegrini M, Comerford I, McColl SR, Schacker TW, Long HM, Estes JD, Busslinger M, Belz GT, Lewin SR, Kallies A*, Yu D*. (2016) CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles. Nature Immunology 17(10):1187-96
He J#, Zhang X#, Wei Y#, Sun X, Chen Y, Deng J, Jin Y, Gan Y, Hu X, Jia R, Xu C, Hou Z, Leong YA, Zhu L, Feng J, An Y, Jia Y, Li C, Liu X, Ye H, Ren L, Li R, Yao H, Li Y, Chen S, Zhang X, Su Y, Guo J, Shen N, Morand EF, Yu D* and Li Z* (2016). Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus. Nature Medicine 22(9): 991-3
Vinuesa CG*, Linterman MA*, Yu D*, MacLennan ICM (2016) Follicular Helper T Cells. Annual Review of Immunology 34:335-68
Yu D, Chen Y, Leong YA (2014) Navigating double negatives: new pathways for regulating T(FH) differentiation. Nature Immunology 15(7): 597-9
Yu D (2014) MicroRNAs in Tfh cells: mircomanaging inflammaging. Immunity 41(4): 509-511
He J#, Tsai LM#, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, Zhu L, Wei W, Wang C, Karnowski A, Belz GT, Ghali JR, Cook MC, Riminton DS, Veillette A, Schwartzberg PL, Mackay F, Brink R, Tangye SG, Vinuesa CG, Mackay CR, Li Z*, Yu D*. (2013) Circulating precursor CCR7loPD-1hi CXCR5+ CD4+ T cells indicate follicular helper T cell activity and promote antibody responses upon antigen re-exposure. Immunity 39(4),770-781
Yu D, Rao S, Tsai LM, Lee SK, He Y, Sutcliffe EL, Srivastava M, Linterman M, Zheng L, Simpson N, Ellyard JI, Parish IA, Ma C, Li QJ, Parish CR, Mackay CR*, Vinuesa CG* (2009) Transcriptional repressor Bcl-6 directs Tfh lineage commitment. Immunity 31(3), 457-68
Yu D, Tan AH, Hu X, Athanasopoulos V, Simpson N, Silva DG, Giles KM, Leedman PJ, Huttloff A, Lam KP, Goodnow C*, Vinuesa CG*. (2007) Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature 450, 299-303.