Associate Professor Simeonovic is leader of the Diabetes/Transplantation Immunobiology Group in the Department of Immunology and Infectious Disease at The John Curtin School of Medical Research (JCSMR), ANU. She has over 30 years of experience in diabetes research and focuses on the pathogenesis of Type 1 diabetes (T1D) and the molecular mechanisms responsible for beta cell loss in Type 2 diabetes. Her earlier research focussed on the immunobiology of islet transplantation as a treatment for established Type 1 diabetes.
She has supervised 28 PhD, Honours, Masters and undergraduate students (1998-ongoing) and examined > 20 PhD, Honours and MSc theses (1995-2015).
Associate Professor Simeonovic is a member of the Cell Transplantation Editorial Board (1998-) and is a member of the Diabetes Australia Advisory Panel (2015-present).
The pathogenesis of autoimmune diabetes, interventions to prevent the progression of the disease process and the treatment of the established disease by pancreatic islet transplantation. Strategies are being developed to protect the integrity of pancreatic islet tissue from autoimmune damage and to facilitate the long-term survival of islet allografts without the use of conventional immunosuppression.
Associate Professor Simeonovic has been awarded over $12 million in research funding.
(i) For 1990-2016: 8 international Juvenile Diabetes Research Foundation (JDRF) Research grants (1990-2013), 6 NHMRC grants (1984-85, 1994-95, 1996-98, 2003-05, 2013-2015, 2014-2016), a JDFI/JDFA/NHMRC Diabetes Collaborative Research grant (1998-2002), 7 Diabetes Australia Research grants (2004-2013) and a NHMRC/JDRF Special Program Grant (2008-2012).
(ii) For 2017-2020: Associate Professor Simeonovic has been awarded a $1.5 million in funding as a JDRF/ARC Type 1 Diabetes Clinical Research Network Innovative Grant, representing a collaboration with Professor Chris Parish, Associate Professor Elizabeth Gardiner and Dr Lucy Coupland at JCSMR, Professor Beng Chong at UNSW and Dr Manuela Battaglia, San Raffaele Scientific Research Institute, Milan, Italy.
Recent Grant Funding:
- NHMRC Project Grant 2014-2016: Impact of islet beta cell heparan sulfate in Type 2 diabetes (Primary Investigator)
- NHMRC Project Grant 2013-2015: Mechanism of protection of islet beta cells from T1D by heparan sulfate (Primary Investigator)
- NHMRC/JDRF Special Program Grant in Type 1 Diabetes 2008-2012: Role of heparan sulfate, heparanase and heparanase inhibitors in the development and prevention of Type I Diabetes (Secondary Investigator)
- Dynamic Flow Chamber System for the Visualisation and Quantification of Cell Adhesion Under Flow Conditions (Secondary Investigator)
- Request for an Olympus Light Microscope with Digital Camera (Primary Investigator)
- Dual Forma Series II Universal Water Jacketed CO2 Incubator (Primary Investigator)
- NHMRC Project Grant 2003-2005: Major Porcine Antigens for the Generation and Induction of Immune Responses to neovascularised Pig Tissue Xenografts (Primary Investigator)