Dr Alexandra Hackmann

Postdoctoral Fellow
 +61 2 612 58146

Profile

Qualifications

PhD

Biography

2016 - Present

Postdoctoral Fellow - The Fischer Group - Epigenetics and Genomic Stability

Research Topic: RNA surveillance and Genomic stability

2010 - 2016

Postdoctoral Staff Scientist and Lecturer , Goettinger Centre for Molecular Biosciences, Goettingen, Germany

Research topic: RNP metabolism

2005 - 2010

PhD thesis in Professor Heike Krebber's Laboratory, Institute for Molecular Biology and Tumor Research (IMT), Marburg, Germany

Thesis: Characterization of the nuclear/cytoplasmic export requirements of shuttling SR like proteins and their regulatory function in mRNA splicing

Publications

Zander G*, Hackmann A*, Bender, L*, Becker D, Lingner T, Salinas G and Krebber H (2016) mRNA quality control is bypassed for an immediate export of stress responsive transcripts. Nature 540, 593–596

Neumann B, Wu H, Hackmann A and Krebber H (2016) Nuclear Export of Pre-Ribosomal Subunits Requires Dbp5, but Not as an RNA-Helicase as for mRNA Export. PLOS ONE 12;11(2):e0149571

Hackmann A, Wu H, Schneider UM, Meyer K, Jung K and Krebber H. Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1. Nature Communications (2014); 5(3123).

Hackmann A and Krebber H. mRNA Export in Fungi, book chapter 4 in Fungal RNA Biology, Springer  (2014). 

Baierlein C, Hackmann A, Gross T, Henker L, Hinz F and Krebber H. Monosome formation during translation Initiation requires the Serine/Arginine-rich protein Npl3. Molecular Cell Biology (2013); 33(24):4811-23.

Hackmann A, Gross T, Baierlein C and Krebber H. The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits. EMBO reports (2011);12,1024-1031.

Hilger D, Böhm M, Hackmann A, Jung H. Role of Ser-340 and Thr-341 in trans-membrane domain IX of the Na+/proline transporter PutP of Escherichia coli in ligand binding and transport. Journal of Biological Chemistry (2008) 22;283(8):4921-9.

Updated:  24 October 2017/Responsible Officer:  Director, JCSMR/Page Contact:  Web Manager