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Muscle Research Group

Publications

Beard N. A, Wei L, Cheung S. N, Kimura T, Varsányi M, Dulhunty A. F (2008). Phosphorylation of skeletal muscle calsequestrin enhances its Ca(2+) binding capacity and promotes its association with junctin. Cell calcuim E-pub

Feng W, Tu J, Pouliquin P, Cabrales E, Shen X, Dulhunty A, Worley P. F, Allen P. D, Pessah I. N. (2008) Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1. Cell Calcium. 43(3),307-14.

Wei L, Abdellatif Y. A, Liu D, Kimura T, Coggan M, Gallant E. M, Beard N. A, Board P. G, Dulhunty A. F. (2008). Int J Biochem Cell Biol.40(8),1616-28.

Cromer B. A, Gorman M. A, Hansen G, Adams J. J, Coggan M, Littler D. R, Brown L. J, Mazzanti M, Breit S. N, Curmi P. M, Dulhunty A. F, Board P. G, Parker M. W. (2007). Structure of the Janus protein human CLIC2. J Mol Biol. 374(3),719-31.

Goonasekera S. A, Beard N. A, Groom L, Kimura T, Lyfenko A. D, Rosenfeld A, Marty I, Dulhunty A. F, Dirksen R. T. (2007). Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation contraction coupling. J Gen Physiol. 130(4), 365-78.

Abdellatif, Y., Liu, D., Gallant, E. M., Gage, P. W., Board, P. G., and Dulhunty, A. F. (2007). The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels. Cell Calcium 41(5), 429-40.

Bannister, M. L., Hamada, T., Murayama, T., Harvey, P. J., Casarotto, M. G., Dulhunty, A. F., and Ikemoto, N. (2007). Malignant hyperthermia mutation sites in the Leu(2442)-Pro(2477) (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area. Biochem J 401(1), 333-9.

Kimura, T., Pace, S.M., Wei, L., Beard, N.A., Dirksen, R.T., and Dulhunty, A.F.,2007, A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction. Biochem J. 401(1), 317-24.

Dulhunty, A. F., Beard, N. A., Pouliquin, P., and Casarotto, M. G.2007, Agonists and antagonists of the cardiac ryanodine receptor: potential therapeutic agents? Pharmacol Ther. 113(2):247-63.

Wei, L., Varsanyi, M., Dulhunty, A.F., and Beard, N.A., 2006, The conformation of calsequestrin determines its ability to regulate skeletal ryanodine receptors. Biophys J 91(4), 1288-301.

Pouliquin, P., Pace, S.M., Curtis, S.M., Harvey, P.J., Gallant, E.M., Zorzato, F., Casarotto, M.G., and Dulhunty, A.E., 2006, Effects of an alpha-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: Modulation by Homer. International Journal of Biochemistry and Cell Biology 38(10), 1700-1715.

Gibbs, G.M., Scanlon, M.J., Swarbrick, J., Curtis, S., Gallant, E., Dulhunty, A.F., and O'Bryan, M.K., 2006, The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. Journal of Biological Chemistry 281(7), 4156-4163.

Dulhunty, A.F., Beard, N.A., Pouliquin, P., and Kimura, T., 2006, Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies. Journal of Muscle Reasech and Cell Motility 27(5-7), 351-365.

Dulhunty, A.F., 2006, Excitation-contraction coupling from the 1950s into the new millennium. Clinical and Experimental Pharmacology and Physiology 33(9), 763-772.

Casarotto, M.G., Cui, Y.F., Karunasekara, Y., Harvey, P.J., Norris, N., Board, P.G.,and Dulhunty, A.F., 2006, Structural and functional characterization of interactions between the dihydropyridine receptor II-III loop and the ryanodine receptor. Clinical and Experimental Pharmacology and Physiology 33(11), 1114-1117.

Dulhunty, A. F., Pouliquin, P., Coggan, M., Gage, P. W., and Board, P. G. (2005). A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. Biochem J 390(Pt 1), 333-43.

Kimura, T., Nakamori, M., Lueck, J.D., Pouliquin, P., Aoike, F., Fujimura, H., Dirksen, R.T., Takahashi, M.P., Dulhunty, A.F., and Sakoda, S., (2005), Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1. Human Molecular Genetics 14(15), 2189-2200.

Haarmann, C.S., Dulhunty, A.F., and Laver, D.R., 2005, Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+. Journal of Biochemistry 387(part 2), 429-436.

Dulhunty, A.F., Karunasekara, Y., Curtis, S.M., Harvey, P.J., Board, P.G., and Casarotto, M.G., (2005), Role of some unconserved residues in the "C" region of the skeletal DHPR II-III loop. Frontiers of Bioscience 10, 1368-81.

Cui, Y.F., Karunasekara, Y., Harvey, P.J., Board, P.G., Dulhunty, A.F., and Casarotto, M.G., (2005), Letter to the editor: H-1, N-13 and N-15 assignments for the II-III loop region of the skeletal dyhydropyridine receptor. Journal of Biomolecular NMR 32(1), 89-90.

Beard, N.A., Casarotto, M.G., Wei, L., Varsanyi, M., Laver, D.R., and Dulhunty, A.F., (2005), Regulation of ryanodine receptors by calsequestrin: Effect of high luminal Ca2+ and phosphorylation. Biophysical Journal 88(5), 3444-3454.

Dulhunty, A.F., Karunasekara, Y., Curtis, S.M., Harvey, P.J., Board, P.G., and Casarotto, M.G., (2005), The recombinant dihydropyridine receptor II-III loop and partly structured 'C' region peptides modify cardiac ryanodine receptor activity. Biochemical Journal 385, 803-813.

Dulhunty, A.F., Cengia, L., Young, J., Pace, S.M., Harvey, P.J., Lamb, G.D., Chan, Y.N., Wimmer, N., Toth, I., and Casarotto, M.G., (2005), Functional implications of modifying RyR-activating peptides for membrane permeability. British Journal of Pharmacology 144(6), 743-754

Gallant, E.M., Hart, J., Eager, K., Curtis, S., and Dulhunty, A.F., (2004), Caffeine sensitivity of native RyR channels from normal and malignant hyperthermic pigs: effects of a DHPR II-III loop peptide. American Journal of Physiology-Cell Physiology 286(4), C821-C830.

Dulhunty, A.F., Curtis, S.M., Watson, S., Cengia, L., and Casarotto, M.G., (2004), Multiple actions of imperatoxin a on ryanodine receptors - Interactions with the II-III loop "A" fragment. Journal of Biological Chemistry 279(12), 11853-11862.

Dulhunty, A.F., Curtis, S.M., Cengia, L., Sakowska, M., and Casarotto, M.G., (2004), Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release. Biochemical Journal 379, 161-172.

Dulhunty, A.F., Cengia, L., Young, J., Pace, S.M., Harvey, P.J., Lamb, G.D., Chan, Y.N., Wimmer, N., Toth, I., and Casarotto, M.G., (2004), Functional implications of modifying RyR-activating peptides for membrane permeability. British Journal of Pharmacology 1, 1-12.

Casarotto, M.G., Green, D., Pace, S., Young, J., and Dulhunty, A.F., (2004), Activating the ryanodine receptor with dihydropyridine receptor 11-111 loop segments: size and charge do matter. Frontiers in Bioscience 9, 2860-2872.

Board, P.G., Coggan, M., Watson, S., Gage, P.W., and Dulhunty, A.F.,(2004), CLIC-2 modulates cardiac ryanodine receptor Ca(2+) release channels. The International Journal of Biochemistry & Cell Biology 36, 1599-1612.

Beard, N.A., Laver, D.R., and Dulhunty, A.F., (2004), Calsequestrin and the calcium release channel of skeletal and cardiac muscle. Progress in Biophysics & Molecular Biology 85(1), 33-69.

Dulhunty AF, Pouliquin P ., (2003). "Brief Review" What we don't know about the structure of Ryanodine receptor calcium release channels. Clinical and Experimental Pharmacology and Physiology  30, 713-723

Haarmann CC, Green D, Casarotto MG, Laver DR and Dulhunty AF (2003). The random-coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors. Journal of Biochemistry 372, 305-316.

Green D, Pace S, Curtis SM, Sakowska M, Lamb GD, Dulhunty AF, Casarotto MG (2003). The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segment. Biochem J 370, 517-527.

Dulhunty AR, Laver DR (2002) A Ca2+-activated anion channel in the sarcoplasmic reticulum of skeletal muscle. Curr Top Membr 53, 59-80.

Dulhunty AF, Haarmann CS, Green D, Laver DR, Board PG and Casarotto MG (2002). Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle. Progress in Biophysics and Molecular Biology 79, 45-75.

BEARD N..A., SAKOWSKA M.M., DULHUNTY A.F., LAVER D.R. (2002). Calsequestrin is an inhibitor of skeletal muscle ryanodine receptor calcium release channels. Biophysical Journal . 82,310-320

GALLANT E.M., CURTIS S., PACE S.M., DULHUNTY A.F. (2001). ARG(615)Cys substitution in pig skeletal ryanodine receptors increases activation of single channels by a segment of the skeletal DHPR II-III loop. Biophysical Journal. 80, 1769-1782

CASAROTTO M.G., GREEN D., PACE S.M., CURTIS S. M., DULHUNTY A.F. (2001) Structural determinants for activation or inhibition of ryanodine receptors by basic residues in the dihydropyridine receptor II-III loop. Biophysical Journal. 80, 2715-2726

LAVER D.R., LENZ G.K., DULHUNTY A.F.( 2001). Phosphate ion channels in sarcoplasmic reticulum of rabbit skeletal muscle. Journal of Physiology. 535(Pt 3): 715-728.

DULHUNTY A., GAGE P., CURTIS S., CHELVANAYAGAM G., BOARD P. (2001).The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. J. Biological Chenistry. 276, 3319-3323
 

DULHUNTY A. F., LAVER D., CURTIS S., PACE S., HAARMANN C and GALLANT E.M. (2001). Characteristics of irreversible ATP activation suggest that native skeletal ryanodine receptors can be phosphorylated via an endogenous CAMKII. Biophysical Journal. 81,3240-3252

MOULD, J.M. and DULHUNTY, A.F. (2000)  Delayed contractures induced by external cadmim ions in rat soleus fibres.  Pflugers Archiv   439, 263-270 
 
 DULHUNTY, A.F., HART, J.D., HAARMANN, C. and GREEN, D. (2000)  Oxidation, reduction and S-nitrosylation of ryanodine receptors.  Forum on redox regulation of cardiac and skeletal sarcoplasmic reticulum. Antioxidants and Redox Signalling   1, 27-35 

 HART, J.D.E. and DULHUNTY, A.F. (2000)  Nitric oxide activates and inhibits the calcium release channel  (ryanodine receptors) of skeletal muscle. J. Membrane Biol.   173, 227-236

 CASAROTTO, MG., GIBSON, F., PACE, S.M., CURTIS, S.M., MULCAIR, M. and DULHUNTY, A.F. (2000)  A structural requirement for activation of skeletal and cardiac RyRs by a 20 amino acid region in the 11-111 loop of the skeletal DHPR.  J. Biol. Chem  257, 11631-11637 

 MOULD, J. and DULHUNTY, A.F. (2000)  Cadmium withdrawal contractures in rat soleus muscle fibres. Pflugers Archiv  440, 68-74 

 GREEN, D., PACE, S.M., HURNE, A., WARING, P., HART, J.D. and DULHUNTY, A.F. (2000)  Skeletal muscle ryanodine receptor channels are activated by the fungal metabolite, gliotoxin.  J. Membrane Biol. (in press)

AHERN, G.P., JUNANKAR, P.R. and DULHUNTY, A.F. (1997) Subconductance states in single channel activity of skeletal muscle ryanodine receptor afrer removal of FKBP12.  Biophys. J. 72, 146-162. 

 AHERN, G.P., JUNANKAR, P.R. and DULHUNTY, A.F. (1997). Ryanodine receptors from rabbit skeletal muscle are reversibly activated by rapamycin . Neurosci. Letts. 225, 81-84. 

 EAGER, K.R., RODEN, L.D. and DULHUNTY, A.F. (1997) Actions of sulfhydryl reagents on single ryanodine receptor calcium release channels from sheep myocardium.  Am. J. Physiol. 272, C1908-C1918 

 KOURIE, J.I. (1997) Painting optimal bilayers for recording ion channels. In Neuroscience Methods: A Guide for Advanced Students, ed. R.L. Martin, Harwood Academic Press, The Netherlands, Chapter 3, pp.17-22. 

 KOURIE, J.I. (1997) A redox O2 sensor modulates the SR Ca2+ countercurrent through voltage- and Ca2+-dependent Cl- channels. American Physiol. Soc., 272, C324-C332 

 KOURIE, J.I. (1997) ATP-sensitive voltage- and calcium-dependent chloride channels in sarcoplasmic reticulum vesicles from rabbit skeletal muscle.  Am. J. Physiol. 157, 39-51 

 KOURIE, J.I., FOSTER, P.S. and DULHUNTY, A.F. (1997) Inositol polyphosphates modify the kinetics of a small chloride channel in skeletal muscle sarcoplasmic reticulum.  J. Membrane Biol. 157, 147-158 

 LAVER, D. (1997) Analysis of single channel recordings. In Neuroscience Methods A Guide for Advanced Students, R.L. Martin (ed), Harwood Academic Press, The Netherlands, Chapter 7, pp.46-52. 

 LAVER, D.R., BAYNES, T.M. and DULHUNTY, A.F. (1997) Identification and characterisation of two Mg2+-inhibition mechanisms in ryanodine receptor Ca2+ channels.  J. Membrane Biol. 156, 213-229. 

 LAVER, D.R. and GAGE, P.W. (1997) Interpretation of substates in ion channels: unipores or multipores.  Prog. in Biophys. & Molec. Biol., 67, 99-140 

 LAVER, D.R., OWEN, V.J., JUNANKAR, P.R., TASKE, N.L., DULHUNTY, A.F. and LAMB, G.D. (1997). Reduced inhibitory effect of Mg2+ on ryanodine receptor -Ca2+ release channels in Malignant Hyperthermia.  Biophys. J. 73, 1913-1924 

LAVER, D.R., CHERRY, C. and WALKER, N.A. (1997) The actions of calmodulin antagonists W-7 and TFP and of calcium on the gating kinetics of the calcium-activated large conductance potassium channel of the Chara protoplasmic drop: A substate-sensitive analysis.  J. Membrane Biol., 155, 263-274 

 McCULLOCH, S.R., LAVER, D.R. and WALKER, N.A. (1997) Modelling Cooperative Anion Channel Activity in Chara Plasma Membrane.  J. Exp. Bot., 48, 383-397 

 EAGER, K. R. and DULHUNTY, A.F. (1998) Activation of the cardiac ryanodine receptor by sulfhydryl oxidation is modified by Mg2+ and ATP  J. Membrane Biol. 163 ,9-18 

 AHERN, G.P. and LAVER, D.R. (1998) ATP inhibition and rectification of Ca2+ -activated anion channel in sarcoplasmic reticulum of skeletal muscle.  Biophys. J. 

 LAVER, D.R. and LAMB, G.D. (1998) Inactivation of Ca2+ release channels (ryanodine receptors RyR1 and RyR2) with rapid steps in [Ca2+] and voltage.  Biophys. J. 

 MOULD, J. and DULHUNTY, A.F. (1999) Effects of external cadmium ions on excitation-contraction coupling in rat soleus fibres. Pflugers Arch 437,197-203 

 AHERN,G.P., JUNANKAR, P.R., PACE, S.M., CURTIS, S.M., MOULD, J.A. and DULHUNTY, A.F. (1999) Effects of ivermectin and midecamycin on ryanodine receptors and the Ca2+ ATPase in the sarcoplasmic reticulum of rabbit and rat skeletal muscle.  J.Physiol. 514,313-326 

 EAGER, K.R. and DULHUNTY, A.F. (1999) Cardiac ryanodine receptor activity is altered by oxidising reagents in either the luminal or cytoplasmic solutions.  J. Membrane Biol. 167, 205-214 

 DULHUNTY, A.F., LAVER, D.R., GALLANT, E.M., CASAROTTO, M.G. and PACE, S.M. (1999) Activation and inhibition of skeletal RyR channels by a part of the skeletal DHPR 11-111 loop: effects of Ser ⁶⁸⁷ and FKBP12.  Biophys J.  77, 189-203 

HAARMANN, C.S., FINK, R.H.A. and DULHUNTY, A.F. (1999)  Oxidation and reduction of pig skeletal muscle ryanodine receptors. Biophysical J.  77, 3010-3022