2008

Ong SLH, Zhang Y, Whitworth JA. Reactive oxygen species and glucocorticoid-induced hypertension. Clinical and Experimental Pharmacology and Physiology, 35, 477-482.

Krug S, Zhang Y, Mori TA, Croft KD, Vickers JJ, Langton LK, Whitworth JA. N-Acetylcysteine prevents but does not reverse dexamethasone-induced hypertension. Submitted to Clin Exp Pharmacol Physiol. In press

Zhang Y, Hu L, Mori TA, Barden A, Croft KD, Whitworth JA. Arachidonic acid metabolism in glucocorticoid-induced hypertension. Clin Exp Pharmacol Physiol. 2007 Dec 7; [Epub ahead of print]

2007

Wells, R. and Whitworth, JA., 2007, Equitable access: good intentions are not enough. Global Forum Update on Research for Health 4, 151-153.

Whitworth, J.A., Pang, T., 2007, Using Research to Inform Health Policy: A Perspective from the World Health Organization's Advisory Committee on Health Research. Harvard Health Policy Review 8(1): 107-113.

Mendis, S., Lindholm, L.H., Mancia, G., Whitworth, J.A., Alderman, M., Lim, S., Heagerty, T., 2007, World health Organization (WHO) and International Society of Hypertension (ISH) risk prediction chards; assessment of cardiovascular risk for prevention and control of cardiovascular disease in low and middle income countries. Journal of Hypertension 25:1578-1582.

Whitworth, J.A., Overview of Assessment and Investigation of Hypertension: A Pragmatic Practical Approach. Comprehensive Hypertension Chapter 43, p. 515-520.

Whitworth, J.A., World Health Organization/International Society of Hypertension (WHO/ISH): Hypertension Guidelines and Statements. Comprehensive Hypertension Chapter 95, p.1157-1172.

Whitworth, J.A., Should eponyms be abandoned? British Medical Journal 335 pp. 424-5

Whitworth, J.A., 2007, Who said that?. The Lancet 370 (9593), 1128.

Grassi, G., Whitworth, J.A., 2007, Resistant hypertension and aldosterone excess: new insights from ambulatory blood pressure monitoring. Journal of Hypertension 25(10), 2006-2007

Zhang, Y., Miao, Y., and Whitworth, J.A., 2007, Aspirin Prevents and Partially Reverses Adrenocorticotropic Hormone-Induced Hypertension in the Rat. American Journal of Hypertension 20:1222-1228.

Schyvens, C.G., Andrews M.C., Tam, R., Mori, T.A., Croft, K.D., McKenzie, K.U.S., Whitworth, J.A., and Zhang, Y., 2007, Antioxidant
Vitamins and Adrenocorticotrophic Hormone-Induced Hypertension in Rats. Clinical and Experimental Hypertension 29:465-478.

Kelly, JJ., Tam, SH., Williamson, P.M., and Whitworth, J.A., 2007, Decreased Threshold for the Nitric Oxide Donor Glyceryl Trinitrate in Cortisol-Induced Hypertension in Humans. Clinical and Experimental Pharmacology and Physiology 34:1317-1318.

Miao, Y., Zhang, Y., Lim, P.S., Kanjanapan, Y., Mori, T.A., Croft, K.D., Earl, J., Lee, S.Y., McKenzie, K.U.S., Hu, L., and Whitworth, J.A., 2007, Folic Acid Prevents and Partially Reverses Glucocorticoid-Induced Hypertension in the Rat. American Journal of Hypertension 20, 304-310.

Ong SLH, Vickers JJ, Zhang Y, McKenzie KUS, Walsh CE, Whitworth JA. Role of xanthine oxidase in dexamethasone-induced hypertension in rats.Clin Exp Pharmacol Physiol.2007;34:517-519.

2006

Attia, R., D'Este C., Schofield, P.W., Brown, A.M., Gibson, R., Tavener, M., Horsley, K., Harrex, W., Ross, J., and Team., S., 2006, Mental Health in F-111 Maintenance Workers: The Study of Health Outcomes in Aircraft Maintenance Personnel (SHOAMP) General Health and Medical Study. ( Ross, J. on behalf of the SHOAMP team- Whitworth, J. A. Chair Advisory Committee ). Journal of Occupational and Environmental Medicine 48(7), 682-691.

Hu, L., Zhang, Y., Lim, P.S., Miao, Y., Tan, C., McKenzie, K.U.S., Schyvens, C.G., and Whitworth, J.A., 2006, Apocynin but Not l-Arginine Prevents and reverses dexamethasone-induced hypertension in the rat. Amercian Journal of Hypertension 19(4), 413-418.

Mangos, G.J., Walker, B.R., Williamson, P.A., Whitworth, J.A., and Kelly, J.J., 2006, Effect of Synthetic Corticosteroids on Vascular Reactivity in the Human Forearm. Clinical and experimental Hypertension 28(8), 707-718.

Mondo, C.K., Zhang, Y., Possamai, V.D., Miao, Y.C., Schyvens, C.G., McKenzie, K.U.S., Hu, L.X., Guo, Z.J., and Whitworth, J.A., 2006, N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat. Clinical and experimental Hypertension 28(2), 73-84.

Schofield, P.W., Gibson, R., Tavener, M., Attia, R., D'Este C., Guest, M., Brown, A.M., Lee, S.J., Horsley, K., Harrex, W., and Ross, J., 2006, Neurophysiological health in F-111 aircraft maintenance workers. (Schofield, P .W. on behalf of the SHOAMP study team and scientific advisory committee, Chair: Whitworth, J. A.). Neurotoxicology 27(5), 852-60.

Whitworth, J.A., 2006, Best practices in use of research evidence to inform health decisions. Health Research Policy and Systems 4:11(doi:10.1186/1478-4505-4-11).

2005

Hu, L., Zhang, Y., Lim, P.S., Schyvens, C.G., McKenzie, K.U., and Whitworth, J.A., 2005, The NAD(P)H oxidase inhibitor apocynin reverses and prevents dexamethasone-induced hypertension in the rat. Clinical and Experimental Pharmacology and Physiology 32(7), A20-A21.

Miao, Y.C., Zhang, Y., Lim, P.S., Hu, L.X., McKenzie, K.U.S., and Whitworth, J.A., 2005, Folic acid prevented and reversed adrenocorticotropic hormone-induced hypertension in the rats. American Journal of Hypertension 18(5), 184A-185A.

Miao, Y., Zhang, Y., Lim, P., Hu, L., McKenzie, K., and Whitworth, J.A., 2005, Folic acid prevented and reversed adrenocorticotropic hormone-induced hypertension in the rats. Clinical and Experimental Pharmacology and Physiology 32(7), A12-A12.

Shannon, M. F., McKenzie, K. U., Edgley, A., Rao, S., Peng, K., Shweta, A., Schyvens, C. G., Anderson, W. P., Wilson, S. R., Pittelkow, Y. E., Ohms, S., and Whitworth, J. A. (2005). Optimizing microarray in experimental hypertension. Kidney Int 67(1), 364-70.

Tan, C., Schyvens, C.G., P, A., McKenzie, K.U.S., Zhang, Y., and Whitworth, J.A., 2005, The effect of adrenocorticotropic hormone treatment on nitrotyrosine levels in rat organs. Clinical and Experimental Pharmacology and Physiology 32(7), A26-A26.

Whitworth, J.A., 2005, Blood pressure and control of cardiovascular risk. Vascular Health and Risk Management 1, 257-260.

Whitworth JA. Competition in health research: The experience of The John Curtin School of Medical Research. Australia and New Zealand Health Policy, 2005, 2:5.

Whitworth JA. Progression of renal failure - the role of hypertension. Annals Academy of Medicine Singapore; 4: 8-15, 2005.

Whitworth, J.A., Williamson, P., Mangos, G., and Kelly, J.J., 2005, Cardiovascular consequences of cortisol excess. Vascular Health and Risk Management 1(4), 291-299.

Williamson PM, Kohlhagen JL, Mangos GJ, Whitworth JA, Kelly JJ. Acute effects of hydrocorotisone on plasma nitrate/nitrite activity and forearm vasodilator responsiveness in normal human subjects. Clinical and Experimental Pharmacology and Physiology; 32:162-166, 2005.

Williamson, P.M., Tam, S.H., Kelly, J.J., and Whitworth, J.A., 2005, Ganglion blockade does not prevent cortisol-induced hypertension in man. Clinical and Experimental Pharmacology and Physiology 32(4), 294-296.

Zhang, Y., Mori, T.A., Croft, K.D., S, C.G., McKenzie, K.U.S., and Whitworth, J.A., 2005, The role of NAD(P)H oxidase in adrenocorticotropic hormone-induced hypertension in the rat. Clinical and Experimental Pharmacology and Physiology 32(7), A16-A16.

Zhang, Y., Chan, M.M.K., Andrews, M.C., Mori, T.A., Croft, K.D., McKenzie, K.U.S., Schyvens, C.G., and Whitworth, J.A., 2005, Apocynin but not allopurinol prevents and reverses ACTH-induced hypertension in the rat. American Journal of Hypertension 18, 910-916k.

2004

Andrews, M.C., Schyvens, C.G., McKenzie, K.U.S., Zhang, Y., and Whitworth, J.A., 2004, Nitric oxide donation partially reverses adrenocorticotrophic hormone-induced hypertension in rats. Clinical and Experimental Hypertension 26(6), 499-509.

Schyvens, C.G., Cowden, W.B., Zhang, Y., McKenzie, K.U.S., and Whitworth, J.A., 2004, Hemodynamic effects of the nitric oxide donor DETA/NO in mice. Clinical and Experimental Hypertension 26(6), 525-535.

Torpy, D.J., Bachmann, A.G., M; Grice, JE; Harris, JM; Clifton, P; Easteal, S., Jackson, R.V., and Whitworth, J.A., 2004, Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism. Endocrine Research 30(3), 417-429.

Whitworth, J.A., 2004, Relationship between white blood cell count and incident hypertension. American Journal of Hypertension 17(9), 861-861.

Whitworth J. Anti-hypertensive drug treatment in diabetes and renal disease. 3rd Asian-Pacific Congress of Hypertension, Singapore, 2004. LL Ping, CB Lock, V Oh, CT Siong Editors. Medimond, Italy; 2004, 37-41.

Whitworth J. Hypertensive treatment in pregnant women. 3rd Asian-Pacific Congress of Hypertension, Singapore, 2004. LL Ping, CB Lock, V Oh, CT Siong Editors. Medimond, Italy; 2004, 31-35.

Whitworth JA. The need for new drugs: a response (editorial). Australian Prescriber, 27; 2004:137-138.

Whitworth, J.A. and Chalmers, J., 2004, World Health Organisation-International Society of Hypertension (WHO/ISH) Hypertension Guidelines. Clinical and Experimental Hypertension 26(7 & 8), 747-752.

Whitworth, J.A., Mangos, G.J., and Kelly, J.J., 2004, Hypertension in Cushing's syndrome. Secondary Hypertension: Clinical Presentation, Diagnosis, and Treatment, Totowa: Humana Press Inc. pp. 195-220.

Whitworth, J.A., Phillips, M., and Jack, J., 2004, The Wellcome Trust in Australasia: return on investment. Internal Medicine Journal 34(4), 211-NIL_4.

Zhang Y, Andrews MC, Schyvens CS, McKenzie KUS, Whitworth JA. Adrenocorticotropic hormone, blood pressure, and serum erythropoietin concentrations in the rat. Am J Hypertens. 2004;17:457-461.

Zhang, Y; Croft, KD; Mori, TA; Schyvens, CG; McKenzie, KUS; Whitworth, JA. 2004. The antioxidant tempol prevents and partially reverses dexamethasone-induced hypertension in the rat. Am J Hypertens.17 (3): 260-265.

Zhang Y, Pang T, Earl J, Schyvens CS, McKenzie KUS, Whitworth JA. Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the rat. Clin Exp Hypertens. 2004;26:231-241.

2003

Bath, P., Chalmers, J., Powers, W., Beilin, L., Davis, S., Lenfant, C., Mancia, G., Neal, B., Whitworth, J., and Zanchetti, A., 2003, International Society of Hypertension (ISH): Statement on the Management of Blood Pressure in Acute Stroke. Journal of Hypertension 21, 665-672.

Chalmers J, Beilin L, Mancia G, Whitworth J, Zanchetti A (2003). International Society of Hypertension (ISH): Statements on Blood Pressure and Stroke. Journal of Hypertension 21, 649-650.

Chalmers, J., Todd, A., Chapman, N., Beilin, L., Davis, S., Donnan, G., Frommer, M., Huxley, R., Lenfant, C., Macmahon, S., Mancia, G., Mendis, S., Whitworth, J., and Zanchetti, A., 2003, International Society of Hypertension (ISH): Statement on Blood Pressure Lowering and Stroke Prevention. Journal of Hypertension 21, 651-663.

Chalmers J, Beilin L, Mancia G, Whitworth J, Zanchetti A (2003). International Society of Hypertension (ISH): Statement on the Management of Blood Pressure in Acute Stroke. Journal of Hypertension 21, 665-672.

Chin-Dusting JPF, Ahlers BA, Kaye DM, Kelly JJ, Whitworth JA (2003). L-arginine transport in humans with cortisol-induced hypertension. Hypertension 41, 1336-1340.

Gatenby PA, Whitworth JA (2003). Canberra's new medical school. Intern Med J 33, 321-322.

Kaplan, N., Mendis, S., Poulter, N., Whitworth, JA, 2003, World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 21, 1983-1992.

Lin RCY, Schyvens CG, Zhang Y, Whitworth JA, Morris BJ (2003). Tumor mecrosis factor receptor 2 mRNA in rat models of hypertension. American Journal of Hypertension 16, 685-688

Mangos, G.J., Whitworth, J.A., Williamson, P.M., and Kelly, J.J., 2003, Glucocorticoids and the kidney. Nephrology 8(6), 267-273.

Whitworth, J.A., 2003, The Sylvia and Charles Viertel Charitable Foundation: A decade of support for medical research in Australia. Internal Medicine Journal 33(12), 610-612.

Whitworth JA (2003). Emerging drugs in the management of hypertension. Expert Opin. Emerging Drugs 2003, 8:377-388.

Whitworth JA (2003). Hypertension: a major global health problem. Kidney: A Current Survey of World Literature 12, 103-104.

Wing, L.M.H., Reid, C.M., Ryan, P., Beilin, L.J., Brown, M.A., Jennings, G.L.R., Johnston, C.I., McNeil, J.J., MacDonald, G.J., Marley, J.E., Morgan, T.O., West, M.J., and Whitworth, J.A., 2003, For the Second Australian National Blood Pressure Study Group. A comparison of outcomes with angiotensin-converting-enzyme inhibitors and diuretics for the treatment of hypertension in the elderly. The New England Journal of Medicine 348(7), 583-592.

Zhang Y, Jang R, Mori TA, Croft KD, Schyvens CG, McKenzie KUS, Whitworth JA (2003). The anti-oxidant Tempol reverses and partially prevents adrenocorticotrophic hormone-induced hypertension in the rat. J Hypertens 21, 1513-1518.

Zhang Y, Schyvens CS, McKenzie KUS, Morris BJ, Whitworth JA (2003). Lipopolysaccharide reverses adrenocorticotrophic hormone-induced hypertension in the rat. Hypertension Research 26, 427-432.

2002

Rummery NM, McKenzie KU, Whitworth JA, Hill CE (2002) Decreased endothelial size and
connexin expression in rat caudal arteries during hypertension. J Hypertens 20, 247-253.

Whitworth JA (2002). Commentary: Nightime blood pressure in pregnancy. Brown MA, Davis GK, McHugh L. The prevalence and clinical significance of nocturnal hypertension in pregnancy in Journal of Hypertension 2001, 19 1437-1444. International Trends in Hypertension 17, 24.

Whitworth JA (2002) Cortico-adrenal hypertension. In Manual of Hypertension (eds G
Mancia, J Chalmers, S Julius, T Saruta, M Weber, A Ferrari, I Wilkinson), Churchill
Livingston pp 231-245.

Whitworth JA (2002) Hypertension. In: Practical Guide to Geriatric Medicine, edited by Janjit
N Ratnaike, McGraw Hill, Sydney, pp 302-312.

Whitworth JA, Lawrence JR, eds (2002). Textbook of Renal Disease. Churchill Livingstone, Edinburgh, 2000. Second Edition. Russian Edition. Meditsina Publishing House.

Whitworth JA, Schyvens CG, Zhang Y, Andrews MC, Mangos GJ, Kelly JJ (2002) The nitric
oxide system in glucocorticoid-induced hypertension. J Hypertens 20, 1035-1043.

2001

Chalmers J, Whitworth JA (2001) A half-century of Australian health and medical research. Medical Journal of Australia 174, 29-32.

Denton KM, Li M, Anderson WP and Whitworth JA (2001) Glomerular hypertension and hyperfiltration in adrenocorticotrophin-induced hypertension in rats: the role of nitric oxide. Journal of Hypertension 19, 327-334.

Fraser TB, Turner SW, Mangos GJ, Ludbrook J, Whitworth JA (2001) Comparison of telemetric and tail-cuff blood pressure monitoring in adrenocorticotrophic hormone-treated rats. Clinical and Experimental Pharmacology and Physiology 28, 831-835.

Jackson RV, Nye EJ, Grice JE, Hockings GI, Strakosch CR, Walters MM, Crosbie GV, Torpy DJ, Whitworth JA (2001) Early rise in blood pressure following administration of adrenocorticotropic hormone-[1-24] in humans. Clinical and Experimental Pharmacology and Physiology 28, 773-775.

Kelly JJ, Williamson P, Martin A, Whitworth JA (2001) Effects of oral L-arginine on plasma nitrate and blood pressure in cortisol-treated humans. Journal of Hypertension 19, 263-268

Lou Y-k, Wen C, Li M, Adams DJ, Wang M-x, Yang F, Morris BJ, Whitworth JA (2001) Decreased Renal Expression of Nitric Oxide Synthase Isoforms in Adrenocorticotropin-Induced and Corticosterone-Induced Hypertension. Hypertension 37, 1164-1170.

Schyvens CG, Mangos GJ, Zhang Y, McKenzie KUS, Whitworth JA (2001) Telemetric monitoring of adrenocorticotrophin-induced hypertension in mice. Clinical and Experimental Pharmacology and Physiology 28, 758-760.

Torpy DJ, Bachmann AW, Grice JE, Fitzgerald SP, Phillips PJ, Whitworth JA, Jackson RV (2001) Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension. Journal of Clinical Endocrinology and Metabolism 86, 3692-700.

Turner SW, Fraser TB, Mangos GJ, Whitworth JA (2001) Circadian blood pressure variability in adrenocorticotrophin-induced hypertension in the rat. Hypertension 19,1411-1420.

Turner SW, Mangos GJ, Whitworth JA (2001) Nitric Oxide Synthase Activity in Adrenocorticotrophin-induced hypertension in the rat. Clinical and Experimental Pharmacology and Physiology 28, 881-883.

Whitworth JA John Ludbrook APPS Symposium (2001) Clin Exp Pharmacol P 28, 470-471.

Whitworth JA, Schyvens CG, Zhang Y, Mangos GJ and Kelly JJ (2001) Glucocorticoid-induced hypertension: from mouse to man. Clinical and Experimental Pharmacology and Physiology, 28, 993-996.

2000

Chockalingram A, Chalmers J, Lisheng L, Labarthe D, MacMahon S, Martin I, Whitworth JA (2000) Prevention of cardiovascular diseases in developing countries: agenda for action. J Hypertens 18, 1705-8.

Fraser TB, Turner SW, Wen C, Li M, Burrell L, Whitworth JA (2000) The role of arginine vasopressin in ACTH-induced hypertension in rat. Clinical & Experimental Pharmacology & Physiology 27, 866-870.

Kelly JJ, Lawson JA, Campbell LV, Storlien LH, Jenkins AB, Whitworth JA and O'Sullivan AJ (2000) Effects of nicotinic acid on insulin sensitivity and blood pressure in healthy subjects. Journal of Human Hypertension 14, 567-572.

Kelly JJ, Martin A, Whitworth JA (2000) Role of erythroprotein in cortisol induced hypertension. Journal of Human Hypertension 14, 195-198.

Kelly JJ, Whitworth JA (2000) Current Opinions on the Involvement of Angiotensin II in Hydromineral Balance.In: Drugs, Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of Discovery. Ed Ahsan Husain and Robert M Graham, Harwood Academic Publishers, ISBN 90-5823-038-4, issn 1541-4409, pp 63-66.

Kelly JJ, Whitworth JA (2000) In: renal blood flow in human diseases. The renal circulation (advances in organ biology) ed Anderson WP, Evans RG, Stevenson KM JAI Press Inc Connecticut USA, ISBN: 07623 - 0617-3, Vol 9, pp 347-368.

Mangos GJ, Turner SW, Fraser TB, Whitworth JA (2000) The role of corticosterone in ACTH induced hypertension in the rat. Journal of Hypertension 18, 1849-55.

Mangos GJ, Kelly JJ, Whitworth JA (2000). Cortisol and essential hypertension. Kidney 9, 47-50.

Mangos GJ, Walker BA, Kelly JJ, Lawson JA, Webb DJ, Whitworth JA (2000) Cortisol inhibits cholinergic vasodilation in the human forearm. American Journal of Hypertension 13, 1155-60.

Mangos GJ, Kelly JJ, Whitworth JA (2000) Cushing, Cortisol and Cardiovascular Disease. Hypertension 36, 912-6.

Wen C, Li M, Fraser T, Wang J, Turner SW, Whitworth JA (2000) L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. Blood Pressure 9, 298-304.

Wen C, Li M, Whitworth JA (2000) The role of nitric oxide in adrenocorticotrophin (ACTH) induced hypertension: L-arginine effects reversed by N-nitro-L-arginine. Clinical & Experimental Pharmacology & Physiology 27, 887-90.

Whitworth JA (2000) Commentary: Systolic hypertension, systolic-diastolic hypertension, and thrombotic events. International Trends in Hypertension 11, 23.

Whitworth JA (2000) Correspondence: Effect of oral magnesium supplementation on blood pressure in deoxycorticosterone acetate-induced hypertension in rats. Journal of Hypertension 12, 1877.