Dr Danny Rangasamy
Group Leader

T: +61 2 6125 2758
F: +61 2 6125 2499
E: danny.rangasamy@anu.edu.au

Mail Address:
Genome Biology Program 
The John Curtin School of Medical Research 
GPO Box 334
Canberra  ACT  2601  Australia 

 

 

Our laboratory studies epigenetic control of retrotransposons in the mouse and human genomes. Retrotransposons are biologically active mobile DNA elements that can destabilise the genome, shaping genomic landscapes by insertional mutagenesis, deletion and gene rearrangements. Given the deleterious nature of retrotransposon activity, normal cells must have control mechanisms for transposon activity including DNA methylation, packaging retrotransposons into inactive heterochromatin structures and silencing by repeat-associated small noncoding siRNA pathways. We are interested in mechanisms by which the L1 retrotransposon is regulated in normal healthy cells. Of particular importance is to understand the roles of L1 retrotransposons and their epigenetic control in chromosomal stability and gene regulation, both in normal and diseased cells.

 

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