2009

Ranasinghe C, Ramshaw IA. Immunisation Route Dependent Expression of IL-4/IL-13 Can Modulate HIV-Specific CD8+ CTL Avidity., 2009 Euro J
Immunol, 39 (7), 1819-30.

Ranasinghe C, Ramshaw IA. Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity., 2009 Expert Rev. Vaccines (In press).

2008

Day, S.L., Ramshaw, I.A., Ramsay, A.J., and Ranasinghe, C., 2008, Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy. Journal of Immunology 180(11), 7158-7166.

2007

De Rose, R., Batten, C.J., Smith, M.Z., Fernandez, C.S., Peut, V., Thomson, S., Ramshaw, I.A., Coupar, B.E.H., Boyle, D.B., Venturi, V., Davenport, M.P., and Kent, S.J., 2007, Comparative efficacy of subtype AE simian-human immunodeficiency virus priming and boosting vaccines in pigtail macaques. Journal of Virology 81(1), 292-300.

Ranasinghe, C., Turner, S.J., McArthur, C., Sutherland, D.B., Kim, J.H., Doherty, P.C., and Ramshaw, I.A., 2007, Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8(+) T cells with regime-dependent cytokine/granzyme B profiles. Journal of Immunology 178(4), 2370-2379.

Rollman, E., Smith, M.Z., Brooks, A.G., Purcell, D.F.J., Zuber, B., Ramshaw, I.A., and Kent, S.J., 2007, Killing kinetics of simian immunodeficiency virus-specific CD8(+) T cells: implications for HIV vaccine strategies. Journal of Immunology 179(7), 4571-4579.

2006

Coupar, B.E.H., Purcell, D.F.J., Thomson, S.A., Ramshaw, I.A., Kent, S.J., and Boyle, D.B., 2006, Fowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials. Vaccine 24(99), 1378-1388.

Dale, C.J., Thomson, S., De Rose, R., Ranasinghe, C., Medveczky, C.J., Pamungkas, J., Boyle, D.B., Ramshaw, I.A., and Kent, S.J., 2006, Prime-Boost Strategies in DNA Vaccines. DNA Vaccines - Methods and Protocols, eds. W.M. Saltzman, Totowa, New Jersey, USA: Humana Press Inc. pp. 171-198.

De Rose, R., Sullivan, M.T., Dale, C.J., Kelleher, A.D., Emery, S., Cooper, D.A., Ramshaw, I.A., Boyle, D., and Kent, S.J., 2006, Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials. Human Vaccines 2(134-136).

Harrison, J.M., Bertram, E.M., Boyle, D.B., Coupar, B.E.H., Ranasinghe, C., and Ramshaw, I., 2006, 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine. Vaccine. 24(47-48), 6867-6874.

Harrison, J.M. and Ramshaw, I.A., 2006, Cytokines, skin, and smallpox - A new link to an antimicrobial peptide. Immunity 24(3), 245-247.

Ranasinghe, C., Medveczky, J.C., Woltring, D., Gao, K., Thomson, S., Coupar, B.E.H., Boyle, D.B., Ramsay, A.J., and Ramshaw, I.A., 2006, Evaluation of Fowlpox-Vaccinia Virus Prime-Boost Vaccine Strategies for High-Level Mucosal and Systemic Immunity Against HIV-1. Vaccine.24(31-32), 5881-5895.

Rolph, M., S.,, Young, T., R.,, Shum, B.O.V., Gorgun, C.Z., Schmitz-Peiffer, C., Ramshaw, I.A., Hotamisligil, G.S., and Mackay, C.R., 2006, Regulation of dendritic cell function and T cell priming by the fatty acid-bindilng protein aP2. Journal of Immunology 177(11), 7794-7801.

2005

Dale, C. J., Thomson, S., De Rose, R., Ranasinghe, C., Medveczky, C. J., Pamungkas, J., Boyle, D. B., Ramshaw, I. A., Kent, S. J.,
Prime-Boost Strategies in DNA Vaccines - Methods in Molecular Medicine, Vaccine Methods and protocols 2nd edition, edited by W.M.Saltzman, Human press, New Jersey

Chea, S., Dale, C.J., De Rose, R., Ramshaw, I.A., and Kent, S.J., 2005, Enhanced cellular immunity in macaques following a novel peptide immunotherapy. Journal of Virology 79(6), 3748-3757.

De Rose, R., Chea, S., Dale, C.J., Reece, J., Fernandez, C.S., Wilson, K.M., Thomson, S., Ramshaw, I.A., Coupar, B.E.H., Boyle, D.B., Sullivan, M.T., and Kent, S.J., 2005, Subtype AE HIV-1 DNA and recombinant Fowlpoxvirus vaccines encoding five shared HIV-1 genes: safety and T cell immunogenicity in macaques. Vaccine 23(16), 1949-1956.

Doan, T., Herd, K., Ramshaw, I., Thomson, S., and Tindle, R.W., 2005, A polytope DNA vaccine elicits multiple effector and memory CTL responses and protects against human papillomavirus 16 E7-expressing tumour. Cancer Immunology Immunotherapy 54(2), 157-171.

Kent, S.J., Dale, C.J., Ranasinghe, C., Stratov, I., De Rose, R., Chea, S., Montefiori, D.C., Thomson, S., Ramshaw, I.A., Coupar, B.E., Boyle, D.B., Law, M., Wilson, K.M., and Ramsay, A.J., 2005, Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIV(SF162P3). Vaccine In Press.

Pamungkas, J., De Rose, R., Iskandriati, D., Noviana, R., Paramastri, Y., Dale, C.J., Shoobridge, M., Medveczky, C.J., Ramshaw, I.A., Thomson, S., and Kent, S.J., 2005, Comparison of whole gene and whole virus scrambled antigen approaches for DNA prime and fowlpox virus boost HIV type 1 vaccine regimens in macaques. AIDS Research and Human Retroviruses 21(4), 292-300.

Robbins, S.J., Jackson, R.J., Fenner, F., Beaton, S., Medveczky, J., Ramshaw, I.A., and Ramsay, A.J., 2005, The efficacy of cidofovir treatment of mice infected with ectromelia (mousepox) virus encoding interleukin-4. Antiviral Research 66(1), 1-7.

Thomson, S.A., Jaramillo, A.B., Shoobridge, M., Dunstan, K.J., Everett, B., Ranasinghe, C., Kent, S.J., Gao, K., Medveckzy, J., Ffrench, R.A., and Ramshaw, I.A., 2005, Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use. Vaccine 23(38), 4647-4657.

2004

Duraiswamy, J., Bharadwaj, M., Tellam, J., Connolly, G., Cooper, L., Moss, D., Thomson, S., Yotnda, P., and Khanna, R., 2004, Induction of therapeutic T-cell responses to subdominant tumor-associated viral oncogene after immunization with replication-incompetent polyepitope adenovirus vaccine. Cancer Research 64(4), 1483-1489.

Dale, C.J., De Rose, R., Stratov, I., Chea, S., Montefiori, D.C., Thomson, S., Ramshaw, I.A., Coupar, B.E.H., Boyle, D.B., Law, M., and Kent, S.J., 2004, Efficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virus. Journal of Virology 78(24), 13819-13828.

Dale, C.J., De Rose, R., Wilson, K.M., Croom, H.A., Thomson, S., Coupar, B.E.H., Ramsay, A., Purcell, D.F.J., Ffrench, R., Law, M., Emery, S., Cooper, D.A., Ramshaw, I.A., Boyle, D.B., and Kent, S.J., 2004, Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFN gamma or IL-12. Vaccine 23(2), 188-197.

Henness, S., Davey, M.W., Harvie, R.M., Banyer, J., Wasinger, V., Corthals, G., and Davey, R.A., 2004, Changes in gene expression associated with stable drug and radiation resistance in small cell lung cancer cells are similar to those caused by a single X-ray dose. Radiation Research 161(5), 495-503.

Hamilton, N.H.R., Mahalingam, S., Banyer, J.L., Ramshaw, I.A., and Thomson, S.A., 2004, A recombinant vaccinia virus encoding the interferon-inducible T-cell alpha chemoattractant is attenuated in vivo. Scandinavian Journal of Immunology 59(3), 246-254.

2003

Banyer, J.L., Halliday, D.C.T., Thomson, S.A., and Hamilton, N.H.R., 2003, Combinations of IFN-gamma and IL-4 induce distinct profiles of dendritic cell-associated immunoregulatory properties. Genes and Immunity 4(6), 427-440.

Rolph, M.S. and Ramshaw, I.A., 2003, Interleukin-4-mediated downregulation of cytotoxic T lymphocyte activity is associated with reduced proliferation of antigen-specific CD8(+) T cells. Microbes and Infection 5(11), 923-932.

Mukherjee S, Upham JW, Ramshaw I, et al (2003). Dendritic cells infected with a vaccinia virus interleukin-2 vector secrete high levels of IL-2 and can become efficient antigen presenting cells that secrete high levels of the immunostimulatory cytokine IL-12. Cancer Gene Ther 10, 591-602.

Ada G and Ramshaw I (2003). DNA Vaccination. Expert Opinion on Emerging Drugs 8, 27-36.

Duraiswamy J, Sherritt M, Thomson S, Tellam J, Cooper L, Connolly G, Bharadwaj M, Khanna R (2003). Therapeutic LMP1 polyepitope vaccine for EBV-assolciated Hodgkin disease and nasopharyngeal carcinoma. Blood 101, 3150-3156.

2002

Estcourt MJ, Ramsay AJ, Brooks A, Thomson SA, Medveckzy CJ, Ramshaw IA (2002). Prime-boost immunization generates a high frequency, high-avidity CD8(+) cytotoxic T lymphocyte population. Int Immunol 14, 31-37.

Hamilton N, Banyer J, Hapel A, Mahalingam S, Ramsay A, Ramshaw I, Thomson S. (2002) IFN-gamma regulates murine interferon-inducible t cell alpha chemokine (1-TAC) expression in dendritic cell lines and during experimental autoimmune encephalomyelitis (EAE). Scand J Immunol 55, 171-177.

Webster DE, Cooney ML, Huang ZJ, Drew DR, Ramshaw IA, Dry IB, Strugnell RA, Martin JL, Wesselingh SL (2002). Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine. J Virol 76, 7910-7912.

2001

Jackson RJ, Ramsay AJ, Christensen CD, Beaton S, Hall DF, Ramshaw IA (2001) Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. J Virol 75, 1205-1210.

2000

Banyer JL, Hamilton N H R, Ramshaw IA and Ramsay AJ (2000) Cytokines in innate and adaptive immunity. Reviews in Immunogenetics 2, 359-373.

Dale CJ, Zhao A, Jones SL, Boyle DB, Ramshaw IA, Kent SJ (2000) Induction of HIV-1-specific T-helper responses and type 1 cytokine secretion following therapeutic vaccination of macaques with a recombinant fowlpoxvirus co-expressing interferon-gamma. J Med Primatol 29: 240-247

Kent SJ, Zhao A, Dale CJ, Land S, Boyle DB and Ramshaw IA (2000) A recombinant avipoxvirus HIV-1 vaccine expressing interferon-gamma is safe and immunogenic in macaques. Vaccine 18, 2250-2256.

Lees CJ, Apostolopoulos V, Acres B, Ramshaw I, Ramsay A, Ong CS, McKenzie IFC (2000) Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice. Vaccine. 19, 158-162.

Mukherjee S, Haenel T, Himbeck R, Scott B, Ramshaw I, Lake RA, Harnett G, Phillips P, Morey S, Smith D, Davidson JA, Musk AW and Robinson B (2000) Replication restricted vaccinia as a cytokine gene therapy vector in cancer: persistent transgene expression despite antibody generation. Cancer Gene Therapy 7, 663-670.

Paule M, Ramshaw, I and Simeonovic CJ (2000). Avipox virus vectors for gene delivery to fetal mouse and pig proislets. Transplant Proc 32, 1067.

Ramshaw IA and Ramsay AJ (2000) The prime-boost strategy: exciting prospects for improved vaccination. Immunology Today 21, 160-162.

1999

Cheers C, Janas M, Ramsay A and Ramshaw IA (1999) Use of recombinant viruses to deliver cytokines influencing the course of experimental bacterial infection. Immunology and Cell Biology 77, 324-330.

Ramsay AJ, Kent SJ, Strugnell RA, Suhrbier A, Thomson SA and Ramshaw IA (1999) Genetic vaccination strategies for enhanced cellular, humoral and mucosal immunity. Immunological Reviews 171, 27-44.

Willenborg DO, Fordham S, Staykova MA, Ramshaw IA and Cowden WB(1999) Interferon gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue a possible role for nitric oxide. Journal of Immunology 163, 5278-5286.

Woodberry T, Gardner J, Mateo L, Eisen D, Medvecsky J, Ramshaw IA, Thomson SA, Ffrench RA, Elliott SL, Firat H, Lemonnier FA and Shurbier A (1999) Immunogenicity of an HIV polytope vaccine containing multiple HLA-A2 HIV CD8+ cytotoxic T cell epitopes. Journal of Virology 73, 5320-5325.

1998

Estcourt MJ, Ramshaw IA and Ramsay AJ (1998) Cytokine responses in virus infections: Effects on pathogenesis, recovery and persistence. Current Opinion in Microbiology 1, 411-418.

Kent SJ, Zhao A, Best SJ, Chandler JD, Boyle DB and Ramshaw IA (1998) Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus. Journal of Virology 72, 10180-10188.

Robinson BW, Mukherjee SA, Davidson A, Morey S, Musk AW, Ramshaw I, Smith D, Lake R, Haenel T, Garlepp M, Marley J, Leong C, Caminschi I and Scott B (1998) Cytokine gene therapy or infusion as treatment for solid human cancer. Journal of Immunotherapy 3, 211-217.

Rolph MS, Matthaei KI, Carbone FR, Heath WR and Ramshaw IA (1998) Loss of antiviral cytotoxic T-lymphocyte activity during high-level antigen stimulation. Viral Immunology 11, 183-189

Willenborg DO, Fordham S, O'Brien NC, Cowden WB and Ramshaw IA (1998) Tumour necrosis factor-alpha (TNF?) and lymphotoxin-alpha (LT?) in the pathology of experimental autoimmune encephalomyelitis: Is either one responsible or is there another ligand mediating disease? Research in Immunology 149, 804-810.

1997

Leong KH, Ramshaw IA and Ramsay AJ (1997) Interleukin-7 enhances cell-mediated immune responses in vivo in an IL-2-dependent manner. Viral Immunology 10, 1-9.

Ramsay AJ and Ramshaw IA (1997) Cytokine enhancement of immune responses important for immunocontraception. Reproduction, Fertility and Development 9, 91-97.

Ramsay AJ, Leong KH and Ramshaw IA (1997) DNA vaccination against virus infection and enhancement of antiviral immunity following consecutive immunisation with DNA and viral vectors. Immunology and Cell Biology 75, 382-388.

Ramsay AJ, Ramshaw IA and Ada GL (1997) DNA immunisation. Immunology and Cell Biology 75, 360-363.

Ramshaw IA, Fordham SA, Bernard CC, Maguire D, Cowden WB and Willenborg DO: (1997) DNA vaccines for the treatment of autoimmune disease. Immunology and Cell Biology 75, 409-413.

Ramshaw IA, Ramsay AJ, Karupiah G, Rolph MS, Mahalingam S and Ruby JC (1997) Cytokines and immunity to viral infections. Immunological Reviews 159, 119-135.

Rolph MS and Ramshaw IA (1997) Recombinant viruses as vaccines and immunological tools. Current Opinion in Immunology 9, 517-524.

1996

Baumgart KW, McKenzie KR, Radford AJ, Ramshaw I and Britton WJ: (1996) Immunogenicity and protection studies with recombinant mycobacteria and vaccinia vectors coexpressing the 18-kilodalton protein of Mycobacterium leprae. Infection and Immunity 64, 2274-2281.

Rolph MS, Cowden WB, Medveczky CJ and Ramshaw IA (1996) A recombinant vaccinia virus encoding inducible nitric oxide synthase is attenuated in vivo. Journal of Virology 70, 7678-7685.

Rolph MS, Ramshaw IA, Ruby J, Rockett KA and Cowden WB (1996) Nitric oxide production is increased during murine vaccinia virus infection but may not be important for virus clearance. Virology 217, 470-477.

Sedger L, Ramshaw I, Condie A, Medveczky J, Braithwaite A and Ruby J (1996) Vaccinia virus replication is independent of cellular HSP72 expression which is induced during virus infection. Virology 225, 423-427.

Sharma DP, Ramsay AJ, Maguire DJ, Rolph MS and Ramshaw IA (1996) Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo. Journal of Virology 70, 7103-7107.

Willenborg DO, Fordham SA, Bernard CCA, Cowden WB and Ramshaw IA (1996) Interferon-? plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. Journal of Immunology (Cutting Edge) 157, 3223-3227.

1995

Leong KH, Ramsay AJ, Morin MJ, Robinson HL, Boyle DB and Ramshaw IA: (1995) Generation of enhanced immune responses by consecutive immunisation with DNA and recombinant fowlpox virus. In: Vaccines 95 (ed. Brown, F., Chanock, R., Ginsberg, H. and Norrby, E.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp. 327-331.

Lidbury BA, Ramshaw IA and Sambhi SK: (1995) The role for host-immune factors in the in vivo antiviral effects of TNF. Cytokine 7, 157-164.

Lidbury BA, Ramshaw IA, Rolph MS and Cowden WB (1995) The antiviral activity of tumour necrosis factor on herpes simplex virus type I: Role for a butylated hydroxyanisole sensitive factor. Archives of Virology 140, 703-719.

Ruby J, Bluethmann H, Aguet M and Ramshaw IA (1995) CD40L has potent anti-viral activity. Nature Medicine 1, 437-441.

Willenborg DO, Fordham SA, Cowden WB and Ramshaw IA (1995) Cytokines and murine autoimmune encephalomyelitis: Inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus sytem. Scandinavian Journal of Immunology 41, 31-41.