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Walk

A stochastic simulation of the G-protein cascade of phototransduction.

"Walk" is a program that simulates activation and inactivation in the G-protein cascade of reactions that underlie phototransduction (and a variety of other biological signalling cascades). It was written specifically for Windows 95/98/NT/2000 by Lucian Wischik; there is no Mac version.

• Screenshots of Walk.
   
• Using Walk
   
• Download Walk v2.00 for Windows 95/98/NT/2000 (1.2MB self-extracting EXE file).

Notes:

• On some machines the display must be set to 256 colours for Walk to work correctly.  If you find you cannot see any molecules when you set up a simulation, then go to Windows "Display Properties", then "Settings", and under "Color palette" select "256 color".  At this stage you might also want to change "Font size" to "Small fonts", to ensure that the lettering all fits into the boxes correctly.
• To use Help, you will need to change the Help pointer to the new location of Walk's web page.  After you have started Walk, click "Help", then click "Configure Help", and under "Prefix" enter the new web location, which is "http://jcsmr.anu.edu.au/org/dns/visual/software/walk/index.php".  Note that if you still have problems, then you may need to prefix this by "netscape", or the name of your browser.

Walk v2.00 has a number of advanced features that are only available by password. If you are interested in using any of the following, please contact Trevor Lamb by e-mail at Trevor.Lamb@anu.edu.au

• Dimeric effector protein, PDE
• Inactivation reactions (stochastic or deterministic)
• Stochastic number and position of initial R*s
• Evaluation of the electrical response