Professor Trevor Lamb - Publications (Full papers)

2007 | 2006 |2005 |2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1990 | 1989 | 1988 1987 | 1986 | 1985 | 1984 | 1982 | 1981 | 1980 |

Before 1980

2007

Lamb, T.D., Collin, S.P & Pugh, E.N. Jr (2007). Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience 8, 960-975.
Online

2006

Lamb, T.D. & Pugh, E.N. Jr (2006). Phototransduction, dark adaptation, and rhodopsin regeneration. The Proctor Lecture. Investigative Ophthalmology and Visual Science
47, 5138-5152. Online

Cameron, A.M., Mahroo, O.A.R. & Lamb, T.D. (2006). Dark adaptation of human rod bipolar cells measured from the b wave of the scotopic electroretinogram.
Journal of Physiology 575, 507-526. Online


van Hateren, J.J. & Lamb, T.D. (2006). The photocurrent response of human cones is fast and monophasic. BMC Neuroscience 7, 34. Online | Software

2005

Wenzel, A., Oberhauser, V., Pugh, E.N. Jr., Lamb, T.D., Grimm, C., Samardzija, M., Seeliger, M.W., Reme, C.E., von Lintig, J. (2005). The retinal G protein-coupled receptor (RGR) enhances isomerohydrolase activity independent of light. Journal of Biological Chemistry, 280, 29874-29884. Online

Hamer, R.D., Nicholas, S.C., Tranchina, D., Lamb, T.D. & Jarvinen, J.L.P.(2005). Towards a unified model of vertebrate rod phototransduction. Visual Neuroscience 22, 417-436. Online

Kenkre, J.S., Moran, N.A., Lamb, T.D. & Mahroo, O.A.R. (2005). Extremely rapid recovery of human cone circulating current at the extinction of bleaching exposures. Journal of Physiology 567, 95-112. Online

Jarvinen, J.L.P. & Lamb, T.D. (2005). Inverted photocurrent responses from amphibian rod photoreceptors: role of membrane voltage in response recovery. Journal of Physiology, 566, 455-466. Online

2004

Lamb, T.D. & Pugh, E.N. Jr (2004). Dark adaptation and the retinoid cycle of vision. Progress in Retinal and Eye Research, 23, 307-380. Online

Friedburg, C., Allen, C.P., Mason, P.J. & Lamb, T.D. (2004). Contribution of cone photoreceptors and post-receptoral mechanisms to the human photopic electroretinogram. Journal of Physiology, 556, 819-834. Online

Mahroo, O.A.R. & Lamb, T.D. (2004). Recovery of the human photopic electroretinogram after bleaching exposures: estimation of pigment regeneration kinetics. Journal of Physiology, 554, 417-437. Online

2003

Burns, M.E. & Lamb, T.D. (2003). Visual transduction by rod and cone photoreceptors. In The Visual Neurosciences (ed. Chalupa, L.M.& Werner, L.S.), Chapter 16, pp. 215-233. MIT Press. ISBN 0-262-03308-9.

Hamer, R.D., Nicholas, S.C., Tranchina, D., Liebman, P.A. & Lamb, T.D. (2003). Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses. Journal of General Physiology 122, 419-444. Online

2002

Arshavsky VY, Lamb TD & Pugh EN Jr (2002). G proteins and phototransduction. Annual Review of Physiology 64, 153-187. Online

2001

Friedburg C, Thomas MM & Lamb TD (2001). Time course of the flash response of dark- and light-adapted human rod photoreceptors derived from the electroretinogram. Journal of Physiology 534, 217 242. Online

Nikonov S, Lamb TD & Pugh EN Jr (2001). Photoreceptor sensitivity and kinetics in light adaptation. Journal of General Physiology 117, 365-366. Online

2000

Pugh EN Jr & Lamb TD (2000). Phototransduction in vertebrate rods and cones: molecular mechanisms of amplification recovery and light adaptation. In Handbook of Biological Physics Vol 3, Molecular Mechanisms of Visual Transduction (ed DG Stavenga, WJ de Grip & EN Pugh Jr) Chapter 5, pp 183-255. Elsevier Amsterdam. PDF File

Nikonov S, Lamb TD & Pugh EN Jr (2000). The role of steady phosphodiesterase activity in the kinetics and sensitivity of the light-adapted salamander rod photoresponse. Journal of General Physiology 116, 795 824. Online | Software

Paupoo AAV, Mahroo OAR, Friedburg C & Lamb TD (2000). Human cone photoreceptor responses measured by the ERG a wave during and after exposure to intense illumination. Journal of Physiology 529, 469 482. Online

Leskov IB, Klenchin VA, Handy JW, Whitlock GG, Govardovskii VI, Bownds MD, Lamb TD, Pugh EN Jr & Arshavsky VY (2000). The gain of rod phototransduction: Reconciliation of biochemical and electrophysiological measurements. Neuron 27, 525 537. Online

1999

Pugh EN Jr, Nikonov S & Lamb TD (1999). Molecular mechanisms of vertebrate photoreceptor light adaptation. Current Opinion in Neurobiology 9, 410-418. Online

Whitlock GG & Lamb TD (1999). Variability in the time course of single photon responses from toad rods: termination of rhodopsin's activity. Neuron 23, 337-351. Online

Thomas MM & Lamb TD (1999). Light adaptation and dark adaptation of human rod photoreceptors measured from the a wave of the electroretinogram. Journal of Physiology 518, 479-496. Online

Lamb TD (1999). Photopigments and the biophysics of transduction in cone photoreceptors. In Color Vision: from Genes to Perception (ed Gegenfurtner KR & Sharpe LT ) pp 89-101. Cambridge University Press, New York.

Lamb TD (1999). Alan Hodgkin 1914-98. Nature 397, 112. (Obituary). Online

1998

Leibrock CS, Reuter T & Lamb TD (1998). Molecular basis of dark adaptation in rod photoreceptors. Eye 12, 511-520.

1997

Cideciyan AV, Lamb TD, Pugh EN, Huang Y & Jacobson SG (1997). Rod plateaux during dark adaptation in Sorsby's fundus dystrophy and vitamin A deficiency. Investigative Ophthalmology and Visual Science 38, 1786-1794. Online

Smith NP & Lamb TD (1997). The a-wave of the human electroretinogram recorded with a minimally invasive technique. Vision Research 37, 2943-52. Online

Leibrock CS & Lamb TD (1997). Effect of hydroxylamine on photon-like events during dark adaptation in toad rod photoreceptors. Journal of Physiology 501, 97-109. Online

1996

Lamb TD (1996). Ida Mann Lecture. Transduction in human photoreceptors. Australian and New Zealand Journal of Ophthalmology 24, 105-110.

Murnick JG & Lamb TD (1996). Kinetics of desensitization induced by saturating flashes in toad and salamander rods. Journal of Physiology 495, 1-15. Online

Lamb TD (1996). Gain and kinetics of activation in the G protein cascade of phototransduction. Proceedings of the National Academy of Sciences USA 93, 566-570. Online

1995

Torre V, Ashmore JF, Lamb TD & Menini A (1995). Transduction and adaptation in sensory receptor cells. Journal of Neuroscience 15, 7757-68. Online

Lamb TD (1995). Photoreceptor spectral sensitivities: common shape in the long-wavelength region. Vision Research 35, 3083-3091. Online

Lamb T & Bourriau J (eds) (1995). Colour: Art & Science 237, pp. Cambridge University Press, Cambridge.

1994

Lamb TD (1994). Stochastic simulation of activation in the G protein cascade of phototransduction. Biophysical Journal 67, 1439-1454. Online | Software

Leibrock CS, Reuter T & Lamb TD (1994). Dark adaptation of toad rod photoreceptors following small bleaches. Vision Research 34, 2787-2800. Online

Sesti F, Straforini M, Lamb TD & Torre V (1994). Gating selectivity and blockage of single channels activated by cyclic GMP in retinal rods of the tiger salamander. Journal of Physiology 474, 203-222. Online

Breton ME, Schueller AW, Lamb TD & Pugh EN Jr (1994). Analysis of a wave amplification and kinetics in terms of the G protein cascade of phototransduction. Investigative Ophthalmology and Visual Science 35, 295-309. Online

1993

Pugh EN Jr & Lamb TD (1993). Amplification and kinetics of the activation steps in phototransduction. Biochimica et Biophysica Acta 1141, 111-149. Online

1992

Torre V, Straforini M, Sesti F & Lamb TD (1992). Different channel-gating properties of two classes of cGMP-activated channel in vertebrate photoreceptors. Proceedings of the Royal Society (London) B 250, 209-215.

Matthews HR & Lamb TD (1992). Intracellular messengers in vertebrate photoreceptors: electrophysiological techniques. In Neuromethods Vol 20 Intracellular Messengers (ed Boulton A, Baker G & Taylor C ) pp 471-516. Humana Press.

Lamb TD (1992). The role of cytoplasmic calcium concentration in photoreceptor light adaptation. In Signal Transduction in Photoreceptor Cells (ed Hargrave PA, Hofmann KP & Kaupp UB ) pp 236-258. Springer, Berlin.

Lamb TD & Pugh EN Jr (1992b). G protein cascades: gain and kinetics. Trends in Neurosciences 15, 291-298. Online

Lamb TD & Pugh EN Jr (1992a). A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors. Journal of Physiology 449, 719-757. Online

1990

Lamb TD & Torre V (1990). The control of photoreceptor sensitivity. In Progress in Cell Research 1 (ed Ritchie JM, Magistretti PJ & Bolis L ) pp 109-120. Elsevier, Amsterdam.

Lamb TD (1990b) The role of photoreceptors in light-adaptation and dark-adaptation of the visual system. In Vision: Coding and Efficiency (ed Blakemore C ) pp 161-168. Cambridge University Press, Cambridge.

Lamb TD & Pugh EN Jr (1990). Physiology of transduction and adaptation in rod and cone photoreceptors. Seminars in the Neurosciences 2, 3-13.

Pugh EN Jr & Lamb TD (1990). Cyclic GMP and calcium: the internal messengers of excitation and adaptation in vertebrate photoreceptors. Vision Research 30, 1923-1948. Online

Lamb TD (1990a). Dark adaptation: a re-examination. In Night Vision (ed Hess RF, Nordby K & Sharpe LT ) pp 172-222. Cambridge University Press, Cambridge.

Matthews HR, Fain GL, Murphy RLW & Lamb TD (1990). Light adaptation in cones of the salamander: a role for cytoplasmic calcium concentration. Journal of Physiology 420, 447-469. Online

1989

Lamb TD (1989b). The role of cytoplasmic calcium concentration in light adaptation of rod and cone photoreceptors. Proceedings of the Australian Physiological and Pharmacological Society 20, 15-29.

Lamb TD (1989a). Transduction of light into a neural signal in photoreceptors. Physica Scripta 39, 173-177.

Fain GL, Lamb TD, Matthews HR & Murphy RLW (1989). Cytoplasmic calcium as the messenger for light adaptation in salamander rods. Journal of Physiology 416, 215-243. Online

1988

Matthews HR, Murphy RLW, Fain GL & Lamb TD (1988). Photoreceptor light adaptation is mediated by cytoplasmic calcium concentration. Nature 334, 67-69. Online

Lamb TD & Matthews HR (1988b). Incorporation of analogues of GTP and GDP into rod photoreceptors isolated from the tiger salamander. Journal of Physiology 407, 463-488. Online

Lamb TD & Matthews HR (1988a). External and internal actions in the response of salamander rods to altered external calcium concentration. Journal of Physiology 403, 473-494. Online

1987

Lamb TD (1987c). Sources of noise in photoreceptor transduction. Journal of the Optical Society of America A 4, 2295-2300.
Online

Lamb TD (1987b). Noise in photoreceptors: its sources and implications. Discussions in Neurosciences 4, No 3, Sensory Transduction 124-131.

Lamb TD (1987a). Role of calcium in the light response. Discussions in Neurosciences 4, No 3, Sensory Transduction 104-111.

1986

Torre V, Matthews HR & Lamb TD (1986). Role of calcium in regulating the cyclic nucleotide cascade of phototransduction in retinal rods. Proceedings of the National Academy of Sciences USA 83, 7109-7113. Online

Lamb TD (1986b). Transduction in vertebrate photoreceptors: the roles of cyclic GMP and calcium. Trends in Neurosciences 9, 224-228. Online

Lamb TD (1986a). Photoreceptor adaptation - vertebrates. In The Molecular Mechanism of Photoreception, Dahlem Workshop Reports LS34, 267-286 (ed Stieve H ). Springer, Berlin.

Lamb TD, Matthews HR & Torre V (1986). Incorporation of calcium buffers into salamander retinal rods: a rejection of the calcium hypothesis of phototransduction. Journal of Physiology 372, 315-349. Online

1985

Lamb TD (1985c). An inexpensive digital tape recorder suitable for neurophysiological signals. Journal of Neuroscience Methods 15, 1-13.

Lamb TD (1985a). Properties of cone photoreceptors in relation to colour vision. In Central and Peripheral Mechanisms of Colour Vision. Wenner-Gren Center Symposium Series 43, 151-164 (eds Ottoson D & Zeki S ). Macmillan, London.

Matthews HR, Torre V & Lamb TD (1985). Effects on the photoresponse of calcium buffers and cyclic GMP incorporated into the cytoplasm of retinal rods. Nature 313, 582-585. Online

1984

Lamb TD (1984b). Effects of temperature changes on toad rod photocurrents. Journal of Physiology 346, 557-578. Online

Lamb TD (1984a). Electrical response of photoreceptors. In Recent Advances in Physiology 10, 29-65 (ed Baker PF ). Churchill Livingstone, Edinburgh.

Detwiler PB, Hodgkin AL & Lamb TD (1984). A note on the synaptic events in hyperpolarizing bipolar cells of the turtle retina. In Photoreceptors pp 285 293 (eds Borsellino A & Cervetto L). Plenum, New York.

1982

Baylor DA & Lamb TD (1982). Local effects of bleaching in retinal rods of the toad. Journal of Physiology 328, 49-71. Online

1981

Lamb TD, McNaughton PA & Yau K-W (1981). Spatial spread of activation and background desensitization in rod outer segments. Journal of Physiology 319, 463-496. Online

Lamb TD (1981). The involvement of rod photoreceptors in dark adaptation. Vision Research 21, 1773-1782. Online

Yau K-W, Lamb TD & McNaughton PA (1981). Spread of excitation and background adaptation in the toad rod outer segment. In Current Topics in Membranes and Transport 15, 19-31 (ed Miller WH). Academic, New York.

1980

Lamb TD (1980b). Biophysics of transduction in vertebrate photoreceptors. In Theoretical Approaches in Neurobiology pp 7-17 (eds Reichardt WE & Poggio T). MIT Press, Boston.

Lamb TD (1980a). Spontaneous quantal events induced in toad rods by pigment bleaching. Nature 287, 349-351. Online

McNaughton PA, Yau K-W & Lamb TD (1980). Spread of activation and desensitization in rod outer segment. Nature 283, 85-87. Online

Before 1980

Baylor DA, Lamb TD & Yau K-W (1979b). Responses of retinal rods to single photons. Journal of Physiology 288, 613-634.
Online

Baylor DA, Lamb TD & Yau K-W (1979a). The membrane current of single rod outer segments. Journal of Physiology 288, 589-611. Online

Simon EJ & Lamb TD (1977). Electrical noise in turtle cones. In Vertebrate Photoreception pp 291-304 (eds Barlow HB & Fatt P). Academic Press, London.

Lamb TD & Simon EJ (1977). Analysis of electrical noise in turtle cones. Journal of Physiology 272, 435-468. Online

Yau K-W, Lamb TD & Baylor DA (1977). Light-induced fluctuations in the membrane current of single toad rod outer segments. Nature 269, 78-80. Online

Lamb TD & Simon EJ (1976b). The relation between intercellular coupling and electrical noise in turtle photoreceptors. Journal of Physiology 263, 257-286. Online

Lamb TD (1976). Spatial properties of horizontal cell responses in the turtle retina. Journal of Physiology 263, 239-255. Online

Simon EJ, Lamb TD & Hodgkin AL (1975). Spontaneous voltage fluctuations in retinal cones and bipolar cells. Nature 256, 661-662. Online

Baylor DA, Hodgkin AL & Lamb TD (1974b). Reconstruction of the electrical responses of turtle cones to flashes and steps of light. Journal of Physiology 242, 759-791. Online

Baylor DA, Hodgkin AL & Lamb TD (1974a). The electrical response of turtle cones to flashes and steps of light. Journal of Physiology 242, 685 727. Online