Research

The Molecular Systems Biology Group conducts research on understanding genotype-phenotype correlations in mammalian systems, with an emphasis on human disease and disease models. Our primary focus is on using computational and quantitative approaches to understanding the organization, regulation and function of global gene expression programs. Our work is inherently interdisciplinary, drawing on methodology and approaches from molecular biology, genetics, physiology and the quantitative sciences.

Current projects include:
1. Expression-genetics and applications to human disease and disease models;
2. Development and application of new methods for identifying and exploring gene regulation on a genome-wide level.
3. Identifying signatures of nuclear organization from high-throughput data and implications for control of gene expression.
4. Development and application of visual-analytic approaches to interpreting high-throughput genomic data.
We have ongoing collaborative links with groups at ANU, UNSW, National ICT Australia, The University of Sydney and Harvard Medical School/Massachusetts General Hospital.

Prospective students: I am keen to recruit motivated students for honours and postgraduate degrees. Interested individuals with backgrounds in biology, medicine, bioinformatics, mathematics and statistics, physics or engineering are encouraged to contact Rohan Williams for further discussion.