ANU - The John Curtin School of Medical Research

Epigenetics and Genome Stability Group

Dr Danny Rangasamy
Group Leader

T:   +61 2 6125 2758
F:   +61 2 6125 2499
E:    danny.rangasamy@anu.edu.au

Mail Address:
Division of Molecular Bioscience
The John Curtin School of Medical Research
GPO Box 334
Canberra ACT 2601 Australia

Current Lab Projects
Publications
Staff & Students

Our laboratory studies epigenetic control of retrotransposons in the mouse and human genomes. Retrotransposons are biologically active mobile DNA elements that can destabilise the genome, shaping genomic landscapes by insertional mutagenesis, deletion and gene rearrangements. Given the deleterious nature of retrotransposon activity, normal cells must have control mechanisms for transposon activity including DNA methylation, packaging retrotransposons into inactive heterochromatin structures and silencing by repeat-associated small noncoding siRNA pathways. We are interested in mechanisms by which the L1 retrotransposon is regulated in normal healthy cells. Of particular importance is to understand the roles of L1 retrotransposons and their epigenetic control in chromosomal stability and gene regulation, both in normal and diseased cells.

An invitation to perspective students: Our laboratory would welcome enquiries from Australian and New Zealand or international students interested in Honours or PhD projects in this area of research.

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