Dr David Tremethick- Publications

2007

Fan, J.Y., Zhou, J., and Tremethick, D.J., 2007, Quantitative Analysis of HP1 Binding to Nucleosomal Arrays. Methods In Press.

Greaves, I.K., Rangasamy, D., Ridgway, P., and Tremethick, D.J., 2007, H2A.Z contributes to the unique 3D structure of the centromere. Proceedings of the National Academy of Sciences of the United States of America 104(2), 525-30.

Tremethick, D.J., 2007, Higher-order structures of chromatin: the elusive 30nm fibre. Cell 128(4), 651-654.

Wagstaff, K.M., Glover, D.J., Tremethick, D.J., and Jans, D.A., 2007, Histone-mediated-transductions as an efficient means for gene delivery. Molecular Therapy 15(4), 721-731.

2006

Bulynko, Y.A., Hsing, L.C., Mason, R.W., Tremethick, D.J., and Grigoryev, S.A., 2006, Cathepsin L stabilizes the histone modification landscape on the y chromosome and pericentromeric heterochromatin. Molecular and Cellular Biology 26(11), 4172-84.

Greaves, I.K., Rangasamy, D., Devoy, M., Graves, J.A.M., and Tremethick, D.J., 2006, The X and Y chromosomes assemble into H2A.Z, containing facultative heterochromatin, following meiosis. Molecular and Cellular Biology 26(19), 7343-7343.

Tremethick, D., 2006, Chromatin: the dynamic link between structure and function. Chromosome Research 14(1), 1-4.

Yang, M., Rangasamy, D., Matthaei, K.I., Frew, A.J., Zimmmermann, N., Mahalingam, S., Webb, D.C., Tremethick, D.J., Thompson, P.J., Hogan, S.P., Rothenberg, M.E., Cowden, W.B., and Foster, P.S., 2006, Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness. Journal of Immunology 177(8), 5595-5603.

2005

Bruce, K., Myers, F.A., Mantouvalou, E., Lefevre, P., Greaves, I., Bonifer, C., Tremethick, D.J., Thorne, A.W., and Crane-Robinson, C., 2005, The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken. Nucleic Acids Research 33(17), 5633-5639.

Chakravarthy, S., Bao, Y., Roberts, V.A., Tremethick, D., and Luger, K., 2005, Structural characterization of histone H2A variants. Cold Spring Harbor Symposia on Quantitative Biology 2004 69, 227-234.

2004

Rangasamy, D., Greaves, I., and Tremethick, D.J., (2004), RNA interference demonstrates a novel role for H2A.Z in chromosome segregation. Nature Structural and Molecular Biology 11(7), 650-655.

Bao, Y., Konesky, K., Park, Y.J., Rosu, S., Dyer, P.N., Rangasamy, D., Tremethick, D.J., Laybourn, P.J., and Luger, K., (2004), Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA. Embo Journal 1, 1-11.

Fan, J., Rangasamy, D., Luger, K., and Tremethick, D.J., (2004), H2A.Z alters the nucleosome surface to promote HP1alpha- mediated chromatin fibre folding. Molecular Cell 16(4), 655-661.

Henderson, A., Holloway, A., Reeves, R., and Tremethick, D.J., (2004), Recruitment of SWI/SNF to the human immunodeficiency virus type 1 promoter. Molecular and Cellular Biology 24(1), 389-397.

Park, Y.-J., Dyer, P.N., Tremethick, D.J., and Luger, K., (2004), A new FRET approach demonstrates that the histone variant H2AZ stabilizes the histone octamer within the nucleosome. Journal of Biological Chemistry 279(23), 24274-82.

Ridgway, P., Brown, K.D., Rangasamy, D., Svensson, U., Tremethick, D.J., (2004), Unique residues on the H2A.Z containing nucleosome surface are important for Xenopus laevis development. J Biol Chem 279(42), 43815-20.

Ridgway, P., Rangasamy, D., Berven, L., Svensson, U., and Tremethick, D.J., (2004), Analysis of histone variant H2A.Z localization and expression during early development. Chromatin and Chromatin Remodeling Enzymes, Pt A. 375, San Diego: Academic Press Inc. pp. 239-252.

2003

Satish, D., Tremethick, D.J, and May, B. (2003) Evidence that the coactivatior CBP/p300 is important for phenobarbital-induced but not basal expression of the CYP2H1 gene. Molecular Pharmacology 63, 73-80.

Rangasamy, D., Berven, L., Ridgway, P., and Tremethick, D.J. (2003). Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development. EMBO J. 22, 1599-1607.

2002

Attema JL, Reeves R, Murray V, Levichkin I, Temple MD, Tremethick DJ, Shannon AF (2002). The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation. J Immunol 169, 2466-2476.

Fan J.Y., Gordon F, Luger K, Hansen JC, Tremethick DJ. (2002). The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states. Nature Structural Biology. .9, 172-176

2001

Faast R, Thonglairoam V, Schulz TC, Beall J, Wells JRE, Taylor H, Matthaei K, Rathjen FD, Tremethick DJ, Lyons I. (2001). Histone variant H2A.Z is required for early mammalian development. Current Biology. 11, 1183-1187.

Ridgway P, Almouzni G. (2001). Chromatin assembly and organization. J Cell Sci. 114, 2711-2712.

2000

Johnson-Saliva M, Siddon NA, Clarkson MJ, Tremethick DJ, Jans DA. (2000). Distinct importin recognition properties of histones and chromatin assembly factors. FEBS Lett. 467 (2-3): 169-74.

Guschin D, Geiman TM, Kikyo N, Tremethick DJ, Wolffe AP, Wade PA (2000). Multiple ISW1 ATPase complexes from Xenopus laevis: functional conservation of an ACF/CHRAC homlog. J. Biol. Chem. 275, 35248-35255.

Henderson A, Bunce M, Sidden N, Reeves R and Tremethick D (2000). High-Mobility Group I can modulate binding of transcription factors to the V5 region of the HIV-1 provial promoter. J. Virology. 74, 10523-10534.

Suto K. Clarkson MJ, Tremethick DJ and Luger K. (2000) 2.6A crystal structure of a nucleosome core particle containing the variant histone HLA2. Nature Structural Biology. 7,1121-1124

1999

Tremethick, D.J. (1999). Chromatin Assembly in Xenopus Extracts. Methods in Enzymology, Academic Press 304, 50-63.

Clarkson, M., Wells, J.R.E., Gibson, F., Saint, R. and Tremethick D.J. (1999) The carboxy terminus of His2AvD is essential for variant histone-specific function during Drosophila development. Nature 399, 694-697.

1998

Tremethick, D.J. (1998). Preparation of chromatin assembly extracts from Xenopus oocytes. Methods in Moleuclar Biology "Chromatin" (Humana Press). 119,175-186

1997

Ng, K.W., Ridgway, P., Cohen, D.R. and Tremethick D.J. (1997). The Binding of a Fos/Jun Heterodimer Can Completely Disrupt the Structure of a Nucleosome. EMBO J. 16, 2072-2085.

1996

Tremethick, D.J. and Hyman, L. (1996). High Mobility Group proteins 14 and 17 can prevent the close packing of nucleosomes by increasing the strength of protein contacts in the linker DNA. J.Biol.Chem. 271, 12009-12016.

1994

Tremethick, D.J. (1994). High Mobility Group proteins 14 and 17 can space nucleosomal particles deficient in histones H2A and H2B creating a template that is transcriptionally active. J.Biol.Chem. 269, 28436-28442.