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Biomolecular Structure Group

Publications - Dr Marco Casarotto

Dulhunty, A.F., Beard, N.A., Pouliquin, P., and Casarotto, M.G., 2007, Agonists and antagonists of the cardiac ryanodine receptor: Potential therapeutic agents? Pharmacology and Therapeutics 113(2), 247-263.

Bannister, M.L., Hamada, T., Murayama, T., Harvey, P.J., Casarotto, M.G., Dulhunty, A.F., and Ikemoto, N., 2007, Malignant hyperthermia mutation sites in the Leu 2442-Pro 2477 (DP4) region of RyR1 are clustered in a structurally and functionally definable area. Biochem J. 401(1), 333-9.

Pouliquin, P., Pace, S.M., Curtis, S.M., Harvey, P.J., Gallant, E.M., Zorzato, F., Casarotto, M.G., and Dulhunty, A.E., 2006, Effects of an alpha-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: Modulation by Homer. International Journal of Biochemistry and Cell Biology 38(10), 1700-1715.

Casarotto, M.G., Cui, Y.F., Karunasekara, Y., Harvey, P.J., Norris, N., Board, P.G., and Dulhunty, A.F., 2006, Structural and functional characterization of interactions between the dihydropyridine receptor II-III loop and the ryanodine receptor. Clinical and Experimental Pharmacology and Physiology 33(11), 1114-1117.

Dulhunty, A.F., Karunasekara, Y., Curtis, S.M., Harvey, P.J., Board, P.G., and Casarotto, M.G., 2005, Role of some unconserved residues in the "C" region of the skeletal DHPR II-III loop. Frontiers of Bioscience 10, 1368-81.

Cui, Y.F., Karunasekara, Y., Harvey, P.J., Board, P.G., Dulhunty, A.F., and Casarotto, M.G., 2005, Letter to the editor: H-1, N-13 and N-15 assignments for the II-III loop region of the skeletal dyhydropyridine receptor. Journal of Biomolecular NMR 32(1), 89-90.

Beard, N.A., Casarotto, M.G., Wei, L., Varsanyi, M., Laver, D.R., and Dulhunty, A.F., (2005), Regulation of ryanodine receptors by calsequestrin: Effect of high luminal Ca2+ and phosphorylation. Biophysical Journal 88(5), 3444-3454.

Dulhunty, A.F., Karunasekara, Y., Curtis, S.M., Harvey, P.J., Board, P.G., and Casarotto, M.G.,( 2005), The recombinant dihydropyridine receptor II-III loop and partly structured 'C' region peptides modify cardiac ryanodine receptor activity. Biochemical Journal 385, 803-813.

Dulhunty, A.F., Cengia, L., Young, J., Pace, S.M., Harvey, P.J., Lamb, G.D., Chan, Y.N., Wimmer, N., Toth, I., and Casarotto, M.G., (2005), Functional implications of modifying RyR-activating peptides for membrane permeability. British Journal of Pharmacology 144(6), 743-754.

Tetlow, N., Coggan, M., Casarotto, M.G., and Board, P.G., (2004), Functional polymorphism of human glutathione transferase A3: effects on xenobiotic metabolism and steroid biosynthesis. Pharmacogenetics 14(10), 657-663.

Dulhunty, A.F., Curtis, S.M., Watson, S., Cengia, L., and Casarotto, M.G., (2004), Multiple actions of imperatoxin a on ryanodine receptors - Interactions with the II-III loop "A" fragment. Journal of Biological Chemistry 279(12), 11853-11862.

Dulhunty, A.F., Curtis, S.M., Cengia, L., Sakowska, M., and Casarotto, M.G., (2004), Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release. Biochemical Journal 379, 161-172.

Dulhunty, A.F., Cengia, L., Young, J., Pace, S.M., Harvey, P.J., Lamb, G.D., Chan, Y.N., Wimmer, N., Toth, I., and Casarotto, M.G., (2004), Functional implications of modifying RyR-activating peptides for membrane permeability. British Journal of Pharmacology 1, 1-12.

Casarotto, M.G., Green, D., Pace, S., Young, J., and Dulhunty, A.F., (2004), Activating the ryanodine receptor with dihydropyridine receptor 11-111 loop segments: size and charge do matter. Frontiers in Bioscience 9, 2860-2872.

Haarmann CC, Green D, Casarotto MG, Laver DR and Dulhunty AF (2003). The random-coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors. Journal of Biochemistry 372, 305-316.

Green D, Pace S, Curtis SM, Sakowska M, Lamb GD, Dulhunty AF, Casarotto MG (2003). The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segment. Biochem J 370, 517-527.

Dulhunty AF, Haarmann CS, Green D, Laver DR, Board PG and Casarotto MG (2002). Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle. Progress in Biophysics and Molecular Biology 79, 45-75.

Casarotto MG and Craik DJ (2001) Ring flexibility with in tricyclic antidepressant drugs. Journal of Pharm Sci. 90, 713-721

Casarotto MG, Green D, Pace SM, Curtis SM and Dulhunty AF (2001) Structural Determinants for Activation of Inhibition of Ryanodine Receptors by Basis Residues in the Dihydropyridine Receptor II-III Loop. Biophys Journal. 80, 2715-2726.

Zuegg J, Webb DC, Foster PS and Casarotto MG (2001) A structural model of human IL-13 defines the spatial interactions within the IL-13Ra/IL-4Ra receptor. Immunology and Cell Biology. 79, 332-339

Casarotto MG and Craik DJ (2001) Ring flexibilty within tricyclic antidepressant drugs. J Pharm Sci 90, 713-721.

Casarotto MG, Gibson F, Pace SM, Curtis SM, Mulcair M, Dulhunty AF. (2000). A structural requirement for activation of skeletal ryanodine receptors by peptides of the dihydropyridine receptor II-III loop. J. Biol. Chem. 275 (16): 11631-11637

Flanagan JU, Chelvanayagam G, Casarotto M, Parker MW, Board PG, (2000). A mutagenic analysis of the role of Trp-115 in the human thata class gultathione transferase GSTT2-2. Clin. Chem. & Enzym. Commun. 8: 261-269