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The Australian National University
The John Curtin School of Medical Research
ANU COLLEGE OF MEDICINE AND HEALTH SCIENCES

Asthma and Allergy Group
Dr Dianne Webb- Publications

2007

Webb, D. C., Otczyk, D. C., and Cripps, A. W. (2007). Investigation of the potential of a 48kDa protein as a vaccine candidate for infection against nontypable Haemophilus influenzae. Vaccine 25(20), 4012-9.

Webb, D.C., Cai, Y.P., Matthaei, K.I., and Foster, P.S., 2007, Comparative roles of IL-4, IL-13, and IL-4R alpha in dendritic cell maturation and CD4(+) Th2 cell function. Journal of Immunology 178(1), 219-227.

2006

Yang, M., Rangasamy, D., Matthaei, K.I., Frew, A.J., Zimmmermann, N., Mahalingam, S., Webb, D.C., Tremethick, D.J., Thompson, P.J., Hogan, S.P., Rothenberg, M.E., Cowden, W.B., and Foster, P.S., 2006, Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness. Journal of Immunology 177(8), 5595-5603.

Kumar, R.K., Webb, D.C., Herbert, C., and Foster, P.S., 2006, Interferon-gamma as a Possible Target in Chronic Asthma. Inflamm Allergy Drug Targets 5(4), 253-6.

2004

Webb, D.C., Matthaei, K.I., Cai, Y.P., McKenzie, A.N.J., and Foster, P.S., (2004), Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13(-/-) mice. Journal of Immunology 172(2), 1092-1098.

Kumar, R.K., Herbert, C., Webb, D.C., Li, L., and Foster, P.S., (2004), Effects of anticytokine therapy in a mouse model of chronic asthma. American Journal of Respiratory and Critical Care Medicine 170(10), 1043-1048.

2003

Webb DC, Mahalingam S, Cai Y, Matthaei KI, Donaldson DD, Foster PS. (2003).  Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity.  Eur. J. Immunol,  33, :3377-3385.

Kumar, RK; Herbert, C; Thomas, PS; Wollin, L; Beume, R; Yang, M; Webb, DC; Foster, PS. (2003).  Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma. .J. Pharm. Exp. Ther. 307, 349-355.

Foster PS, Webb DC, Yang M, Herbert C, Kumar RK (2003). Dissociation of Th 2 cytokine-dependent airway lesions from STAT6 signalling in experimental chronic asthma. Clin. Exp. Allergy. 3, 688-695.

2002

Mattes J, Yang M, Mahalingam S, Kuehr J, Webb DC, Simson L, Hogan SP, Koskinen A, McKenzie AN, Dent LA, Rothenberg ME, Matthaei KI, Young IG, Foster PS., (2002).   Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J. Exp. Med.. 195(11):1433-1444.

Foster PS, Hogan SP, Yang M, Mattes J, Young IG, Matthaei KI, Kumar RK, Mahalingam S, Webb DC., (2002).  Interleukin-5 and eosinophils as therapeutic targets for asthma. Trends Mol. Med.  8(4):162-167.

2001

Webb DC, McKenzie AN, Foster PS., (2001).  Expression of the Ym2 lectin-binding protein in the allergic lung is dependent on interleukin (IL)-4 and IL-13 signal transduction:  Identification of a novel allergy-associated protein. J. Biol. Chem. 276(45):41969-41076

Mattes J, Yang M, Siqueira A, Clark K, MacKenzie J, McKenzie AN, Webb DC, Matthaei KI, Foster PS., (2001).  Interleukin-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung. J. Immunol. 167(3):1683-1692.

Harris RM, Webb DC, Howitt SM, Cox GB., (2001.  )Characterization of PitA and PitB from Escherichia coli. J. Bacteriol. 183(17):5008-5014

Zuegg J, Webb DC, Foster PS, Casarotto MG., (2001). A structural model of human IL-13 defines the spatial interactions with the IL-13Ralpha/IL-4Ralpha receptor. Imm. Cell Biol. ; 79(4):332-339.

oster PS, Mould AW, Yang M, Mackenzie J, Mattes J, Hogan SP, Mahalingam S, Mckenzie AN, Rothenberg ME, Young IG, Matthaei KI, Webb DC., (2001).  Elemental signals regulating eosinophil accumulation in the lung. Immun. Reviews. 179;1-9.

Webb DC, McKenzie AN, Matthaei KI, Rothenberg ME, Foster PS., (2001).  Distinct spatial requirement for eosinophil-induced airways hyperreactivity.  Imm. Cell Biol. 79(2):165-169. (invited special feature)

2000

Webb DC, Andrew N, McKenzie J, Koskinen AM, Yang M, Mattes J, Foster PS., (2000). Integrated signals between( IL)-13, IL-4, and IL-5 regulate airways hyperreactivity. J. Immunol. 165(1):108-113.

Webb DC, Cripps AW., (2000).  A P5 peptide that is homologous to peptide 10 from Pseudomonas aeruginosa enhances clearance of nontypeable Haemophilus influenzae from acutely infected rat lung in the absence of detectable peptide-specific antibody. Infect Immun. 68(1):377-381

1999

Webb DC, Foster PS., (1999).  The use of murine models to investigate the immune networks underlying asthama. Curr Opin Anti-Inflamm and immunomod Drugs  1, 433-441 (invited review)

Webb DC, Cripps AW., (1999).  Immunization with recombinant transferrin binding protein B enhances clearance of nontypeable Haemophilus influenzae in a rat pulmonary model.  Infect Immun. 67(5):2138-2144.

Webb DC, Cripps AW., (1999).  A method for the purification and refolding of a recombinant form of the nontypeable Haemophilus influenzae P5 outer membrane protein fused to poly-histidine. Prot. Exp Purif. 15(1):1-7.

1998

Webb DC, Cripps AW., (1998). Secondary structure and molecular analysis of interstrain variability in the P5 outer-membrane protein of non-typable Haemophilus influenzae isolated from diverse anatomical sites. J. Med. Microbiol. 47(12):1059-1067.