Viral Immunology and Molecular
Virology Group
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Dr Matthias Regner, PhD
Research Fellow
Molecular Immunology and Virology
Division of Immunology and Genetics
The John Curtin School of Medical Research
The Australian National Unversity
Building 54, Mills Road
Acton ACT 0200
T: +61 2 6125 3084
E: Matthias.Regner@anu.edu.au
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Biosketch:
Matthias grew up in Germany and studied chemistry in Germany and Denmark. His
interest in immunology began during his Diplom-thesis on a topic in cancer immunology.
His PhD research at JCSMR focused on the immunodominance, cross-reactivities
and effector functions of the cytotoxic T cell response against viral infection,
with an emphasis on Flavivirus infection.
After completion of his PhD he returned to Europe to investigate cytotoxic T
cells and dendritic cells in the neonatal immune system, at the WHO Center for
Vaccinology and Neonatal Immunology in Geneva, Switzerland.
He returned to JCSMR in 2003 where he continues to research the immunobiology
of cytolytic lymphocytes, i.e. cytotoxic T cells and NK cells, in combating
viral infection. His current research interests also include cytokine responses
of the innate immune system.
Opportunities for postgraduate research students:
We focus on the role of cytotoxic T cells and Natural killer cells
in infection with poxviruses and encephalitic RNA viruses. The mechanisms used
to recognize and destroy virus-infected cells are of particular interest. Potential
projects for postgraduate research students would be in the areas of
* Lymphocyte homing to the central nervous system in viral encephalitis; interaction
between virus-specific cytotoxic T cells and virus-infected brain cells.
* Innate and cytotoxic T cell responses during flavivirus infection.
* Mechanisms of recovery and pathology in the infection with poxviruses.
Please refer also to other projects in the group: http://jcsmr.anu.edu.au/org/dig/vi-mv/resopp.php
Feel free to contact group members with any questions or your own ideas regarding
your potential research in the laboratory.
Recent publications:
2006
Alsharifi M, Regner M, Lobigs M, Müllbacher A (2006) Exhaustion
of IFN-I results in increased susceptibility to a second viral infection. J
Immunol (in press).
Müllbacher A, Lobigs M, Alsharifi M, Regner M (2006) Cytotoxic T-cell immunity
as a target for influenza vaccines. The Lancet Infectious Diseases 6:255-256.
2005
Alsharifi M, Lobigs M, Regner M, Lee E, Koskinen A, Müllbacher
A (2005) Type I interferons trigger systemic, partial, lymphocyte activation
in response to viral infection. J Immunol 175:4635-4640
2004
Hu KF, Regner M, Siegrist CA, Lambert PH, Chen M, Lövgren Bengtsson
K, Morein B (2004) The immunomodulating properties of human respiratory syncytial
virus and immunostimulating complexes containing Quillaja saponin components
QH-A, QH-C and ISCOPREP703. FEMS Immunol. Med. Mic. 43:269-276.
Müllbacher A, Regner M, Wang Y, Lee E, Lobigs M, Simon MM (2004) Can we
really learn from model pathogens? Trends Immunol. 25:524-528.
Xu DM, Regner M, Smith D, Ruby J, Johnstone R, Müllbacher A (2004) The
multidrug resistance gene mdr1a influences resistance to ectromelia virus infection
by mechanisms other than conventional immunity. Immunol Cell Biol. 82:462-470.
Regner M, Martinez X, Belnoue E, Sun CM, Boisgerault F, Lambert PH, Leclerc
C, Siegrist CA (2004) Partial activation of neonatal CD11c+ DC and induction
of adult-like CD8+ cytotoxic T cell responses by synthetic microspheres. J.
Immunol. 173:2669-2674.
Regner M, Culley F, Fontanaz P, Hu KF, Morein B, Lambert PH, Openshaw PJ, Siegrist
CA (2004) Safety and efficacy of ISCOM-based antigen delivery systems for neonatal
immunization against respiratory syncytial virus infection. Microbes and Infection
6/7:666-675.
Regner M, Müllbacher A (2004) Granzymes in cytolytic lymphocytes –
to kill a killer? Immunol. Cell Biol. 82:161-169.
2003
Lobigs M, Müllbacher A, Regner M (2003) MHC class I up-regulation
by flaviviruses: Immune interaction with unknown advantage to host or pathogen.
Immunol. Cell Biol 81:217-223.
Martinez X, Regner M, Kovarik J, Zareh S, Bozzotti P, Hauser C, Lambert PH,
Leclerc C, Siegrist CA (2003) CD4-independent protective cytotoxic T cells induced
in early life by a non-replicative antigen delivery system based on virus-like
particles. Virology 305:428-435.
2001
Regner M, Lobigs M, Blanden RV, Müllbacher A (2001) Effector cytolytic
function but not IFN-? production in cytotoxic T cells triggered by virus-infected
target cells in vitro. Scand. J. Immunol. 54:366-374.
Regner M, Lambert PH (2001) Autoimmunity through Infection or Immunization?
Nature Immunol. 2:185-188.
Regner M, Lobigs M, Blanden RV, Milburn P, Müllbacher A (2001) Antiviral
cytotoxic T cells cross-reactively recognize disparate peptide determinants
from related viruses but ignore more similar Self and Foreign determinants.
J. Immunol. 166 :3820-3828.
Regner M (2001) Cross-reactivity in T cell antigen recognition. Immunol. Cell
Biol. 79:91-100.
Regner M, Müllbacher A, Blanden RV, Lobigs M (2001) Immunodominance of
two peptide determinants in the cytolytic T cell response to flavivirus infection:
Inverse correlation of peptide affinity for MHC class I and T cell precursor
frequency. Viral Immunol. 14:135-49.
