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Molecular Immunology and Virology

Publications

2007

Pardo J, Wallich R, Ebnet K, Iden S, Zentgraf H, Martin P, Ekiciler A, Prins A, Müllbacher A, Huber M and Simon M M. (2007). Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin. Cell Death and Differentiation 14, 1768-1779.

Sugui JA, Pardo J, Chang YC, Mullbacher A, Zarember KA, Galvez EM, Brinster L, Zerfas P, Gallin JI, Simon MM, Kwon-Chung KJ.(2007). Role of laeA in the regulation of alb1, gliP, conidial morphology and virulence in Aspergillus fumigatus.. Eukaryotic Cell. 6 (9), 1552-1561

Sugui JA, Pardo J, Chang YC, Zarember KA, Nardone G, Galvez EM, Mullbacher A, Gallin JI, Simon MM, Kwon-Chung KJ. (2007). Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion attenuates virulence in mice immunosuppressed with hydrocortisone. Eukaryotic Cell. 6 (9), 1562-1569

Budd A, Alleva L, Alsharifi M, Koskinen A, Smythe V, Mullbacher A, Wood J, Clark I. (2007). Increased Survival after Gemfibrozil Treatment of Severe Mouse Influenza. Antimicrobial Agents and Chemotherapy, 51 (8), 2965-2968

de Jersey, J., Snelgrove, S.L., Palmer, S.E., Teteris, S.A., Mullbacher, A., Miller, J.F.A.P., and Slattery, R.M., 2007, {beta} Cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice. Proceedings of the National Academy of Sciences of the United States of America 104(4), 1295-1300.

Sutton VR, Waterhouse NJ, Browne KA, Sedelies K, Ciccone A, Anthony D, Koskinen A, Mullbacher A and Trapani JA. (2007). Residual active granzyme B in cathepsin C-null lymphocytes is succicient for perforin-dependent target cell apoptosis. The Journal of Cell Biology, 176 (4) 425-433.

2006

Müllbacher, A., Lobigs, M., Alsharifi, M. and Regner, M. 2006. Cytotoxic T cell immunity as target for influenza vaccines. The Lancet Infectious Disease 6:255-256.

Alsharifi, M., Lobigs, M., Lee, E., Simon, M.M., Kersten, A., Müller, K., Koskinen, A. and Müllbacher, A. 2006. NK cell mediated immunopathology during an acute viral infection of the CNS. Eur. J. Immunol. 36(4): 887-896.

Alsharifi, M., Regner, M., Lobigs, M., Koskinen, A., Lee, E. and Müllbacher, A. 2006. Type-I Interferon exhaustion after a viral infection causes a transient period of reduced resistance to secondary infections. J.Immunol. 177(5), 3235-3241.

Wang, Y., Lobigs, M., Lee, E., Koskinen, A., and Müllbacher, A. 2006 CD8+ T cell mediated recovery and or immunopathology in WNV encephalitis is independent of interferon-gamma.Journal of General Virology 87, 3599-3609.

Pardo, J., Urban, C., Galvez, E. M., Ekert, P. G., Müller U., Kwon-Chung, J., Lobigs, M., Müllbacher, A., Wallich, R., Borner, C. and Simon, M. M.(2006) The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of A. fumigatus virulence in mice. J. Cell Biol. 174: 509-519.

Lee E, Pavy M, Young N, Freeman C, Lobigs M (2006). Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses. Antiviral Res. 69: 31-38.

May F, Lobigs M, Lee E, Gendle, Mackenzie JS, Broom AK, Conlan JV, Hall RA (2006). Biological, antigenic and phylogenetic characterisation of the flavivirus Alfuy. J Gen. Virol. 87: 329-337.

Liu WJ, Wang XJ, Clark DC, Lobigs M, Hall RA, Khromykh AA (2006). A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit interferon alpha/beta induction and attenuates virus virulence in mice. Journal of Virology 80, 2396-2404.

Halenius A, Momburg F, Reinhard H, Bauer D, Lobigs M, Hengel H (2006). Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing (TAP). J. Biol. Chem. 281: 5383-5390.

Lee E, Wright PJ, Davidson A, Lobigs M (2006). Virulence attenuation of dengue virus due to augmented glycosaminoglycan-binding affinity and restriction in extraneural dissemination. Journal of General Virology 87, 2791-2801. Accessible on-line in JGV Direct, a service for rapid publication of papers considered by the Editors to be of special importance.

May, F., Lobigs, M., Lee, E., Gendle, Mackenzie, J.S., Broom, A.K., Conlan, J.V., and Hall, R.A., 2006, Biological, antigenic and phylogenetic characterisation of the flavivirus Alfuy. Journal of Gen Virology 87, 329-337.

2005

Pao, L. I., Sumaria, N., Kelly, J. M., Cretney, E., Wallace, M. E., Uldrich, A., Godfrey, D. I., Papadimitriou, J. M., Müllbacher, A., Rajewski, K., Degli-Eposti, M. A. and Smyth, M.J. 2005. The NK cell protease granzyme M is not critical for NK cell-mediated death, but is involved in host innate response to cytomegalovirus infection. J. Immunol. 175: 3235-3243.

Martin, P., Wallich, R., Pardo, J., Müllbacher, A., Munder, M., Modolell, M. and Markus M. Simon. 2005. Mouse granulocytes do not express granzyme A, granzyme B and perforin, independent of their activation state: similarities or differences with human polymorphonuclear leukocytes? Blood 106:2871-2878.

Alsharifi, M., Regner, M., Lobigs, M., Koskinen, A., Lee, E. and Müllbacher, A. 2005. Type-I interferons, induced in response to virus infections, trigger systemic, partial, lymphocyte activation. J Immunol. 175: 4635-4640.

Lobigs M, Lee E (2005). Coordination of cleavages at the flavivirus C-prM junction: role in virus assembly and virulence. In: Ryan PD, Aaskov JG, St George TG, Dale PER eds. Arbovirus Res. Aust. 9: pp 202-206.

May FJ, Lee E, Lobigs M, Hall RA (2005). Genetic, antigenic and biological characterization of Alfuy virus. In: Ryan PD, Aaskov JG, St George TG, Dale PER eds. Arbovirus Res. Aust. 9: pp 207-210 .

Hu, K.F., Regner, M., Siegrist, C.A., Lambert, P.H., Chen, M., Lövgren Bengtsson, K., , and Morein, B., (2005). The immunomodulating properties of HRSV ISCOMs containing Quillaja saponin components QH-A, QH-C and ISCOPREP-703. FEMS Immunol. Med. Mic. 43:2, 269-276.

 

2004

Lee, E., R. A. Hall, and M. Lobigs. 2004. Common E protein determinants for attenuation of glycosaminoglycan-binding variants of Japanese encephalitis and West Nile viruses. J Virol 78:8271.

Lobigs, M., and E. Lee. 2004. Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranes. J Virol 78:178.

Lobigs, M., A. Müllbacher, and E. Lee. 2004. Evidence that a mechanism for efficient flavivirus budding upregulates MHC class I. Immunol Cell Biol 82:184.

Müllbacher, A., and R. V. Blanden. 2004. T-cell-mediated control of poxvirus infection in mice. Prog Mol Subcell Biol 36:39.

Müllbacher A, Regner M, Wang Y, Lee E, Lobigs M and Simon M. 2004. Can we really learn from model pathogens? Trends in Immunology 25:524-528.

Pardo J, Bosque A, Brehm R, Wallich R, Naval J, Müllbacher A, Anel A and Simon M M. 2004. Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. The Journal of Cell Biology 167: 457-468.

Regner, M., F. Culley, P. Fontannaz, K. Hu, B. Morein, P. H. Lambert, P. Openshaw, and C. A. Siegrist. 2004. Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infection. Microbes Infect 6:666.

Regner, M., X. Martinez, E. Belnoue, C. M. Sun, F. Boisgerault, P. H. Lambert, C. Leclerc, and C. A. Siegrist. 2004. Partial Activation of Neonatal CD11c+ Dendritic Cells and Induction of Adult-Like CD8+ Cytotoxic T Cell Responses by Synthetic Microspheres. J Immunol 173:2669.

Regner, M., and A. Müllbacher. 2004. Granzymes in cytolytic lymphocytes--to kill a killer? Immunol Cell Biol 82:161.

Rode M, Balkow S, V. S, Brehm R, Martin P, Kersten A, Dumrese T, Stehle T, Müllbacher A, Wallich R and Simon M M. 2004. Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection. Journal of Virology 78:12395-12405.

Wang, Y., M. Lobigs, E. Lee, and A. Müllbacher. 2004. Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice. Immunol Cell Biol 82:170.

Xu, D. M., M. Regner, D. Smith, J. Ruby, R. Johnstone, and A. Müllbacher. 2004. The multidrug resistance gene mdr1a influences resistance to ectromelia virus infection by mechanisms other than conventional immunity. Immunol Cell Biol 82:462-470.

2003

Lobigs, M., A. Müllbacher, and M. Regner. 2003. MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen. Immunol Cell Biol 81:217.

Lobigs, M., A. Müllbacher, Y. Wang, M. Pavy, and E. Lee. 2003. Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus. J Gen Virol 84:567.

Lobigs, M., M. Pavy, and R. Hall. 2003. Cross-protective and infection-enhancing immunity in mice vaccinated against flaviviruses belonging to the Japanese encephalitis virus serocomplex. Vaccine 21:1572.

Martinez, X., M. Regner, J. Kovarik, S. Zarei, C. Hauser, P. H. Lambert, C. Leclerc, and C. A. Siegrist. 2003. CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particles. Virology 305:428.

Müllbacher, A. 2003. Cell-mediated cytotoxicity in recovery from poxvirus infections. Rev Med Virol 13:223.

Müllbacher, A., M. Lobigs, and E. Lee. 2003. Immunobiology of mosquito-borne encephalitic flaviviruses. Adv Virus Res 60:87.

Muller, U., V. Sobek, S. Balkow, C. Holscher, A. Müllbacher, C. Museteanu, H. Mossmann, and M. M. Simon. 2003. Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway. Eur J Immunol 33:70.

Wang, Y., M. Lobigs, E. Lee, and A. Müllbacher. 2003. CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitis. J Virol 77:13323.

2002

Baeumner, A. J., N. A. Schlesinger, N. S. Slutzki, J. Romano, E. M. Lee, and R. A. Montagna. 2002. Biosensor for dengue virus detection: sensitive, rapid, and serotype specific. Anal Chem 74:1442.

Lee, E., and M. Lobigs. 2002. Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus. J Virol 76:4901.

Licon Luna, R. M., E. Lee, A. Müllbacher, R. V. Blanden, R. Langman, and M. Lobigs. 2002. Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice. J Virol 76:3202.

Müllbacher, A., M. Lobigs, R. T. Hla, T. Tran, T. Stehle, and M. M. Simon. 2002. Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis. J Immunol 169:145.

2001

Balkow, S., A. Kersten, T. T. Tran, T. Stehle, P. Grosse, C. Museteanu, O. Utermohlen, H. Pircher, F. von Weizsacker, R. Wallich, A. Müllbacher, and M. M. Simon. 2001. Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J Virol 75:8781.

Bhatnagar, A., P. J. Milburn, M. Lobigs, R. V. Blanden, and A. M. Gautam. 2001. Nonobese diabetic mice display elevated levels of class II-associated invariant chain peptide associated with I-Ag7 on the cell surface. J Immunol 166:4490.

Hamilton-Williams, E. E., D. V. Serreze, B. Charlton, E. A. Johnson, M. P. Marron, A. Müllbacher, and R. M. Slattery. 2001. Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proc Natl Acad Sci U S A 98:11533.

Laver, G., A. Müllbacher, and P. Waring. 2001. How commercialization puts a blight on research. Nature 412:765.

Momburg, F., A. Müllbacher, and M. Lobigs. 2001. Modulation of transporter associated with antigen processing (TAP)-mediated peptide import into the endoplasmic reticulum by flavivirus infection. J Virol 75:5663.

Müllbacher, A., and M. Lobigs. 2001. Creation of killer poxvirus could have been predicted. J Virol 75:8353.

Regner, M. 2001. Cross-reactivity in T-cell antigen recognition. Immunol Cell Biol 79:91.

Regner, M., and P. H. Lambert. 2001. Autoimmunity through infection or immunization? Nat Immunol 2:185.

Regner, M., M. Lobigs, R. V. Blanden, P. Milburn, and A. Müllbacher. 2001. Antiviral cytotoxic T cells cross-reactively recognize disparate peptide determinants from related viruses but ignore more similar self- and foreign determinants. J Immunol 166:3820.

Regner, M., M. Lobigs, R. V. Blanden, and A. Müllbacher. 2001. Effector cytolotic function but not IFN-gamma production in cytotoxic T cells triggered by virus-infected target cells in vitro. Scand J Immunol 54:366.

Regner, M., A. Müllbacher, R. V. Blanden, and M. Lobigs. 2001. Immunogenicity of two peptide determinants in the cytolytic T-cell response to flavivirus infection: inverse correlation between peptide affinity for MHC class I and T-cell precursor frequency. Viral Immunol 14:135.

Wallich, R., M. M. Simon, and A. Müllbacher. 2001. Virulence of mousepox virus is independent of serpin-mediated control of cellular cytotoxicity. Viral Immunol 14:71.

Waring, P., and A. Müllbacher. 2001. Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34cdc2 kinase: Fas dependent killing of cells arrested in the cell cycle. Immunol Cell Biol 79:264.

Wu, S. J., E. M. Lee, R. Putvatana, R. N. Shurtliff, K. R. Porter, W. Suharyono, D. M. Watts, C. C. King, G. S. Murphy, C. G. Hayes, and J. W. Romano. 2001. Detection of dengue viral RNA using a nucleic acid sequence-based amplification assay. J Clin Microbiol 39:2794.

2000

Ashman, R. B., A. Müllbacher, and J. M. Papadimitriou. 2000. Role of Fas/FasL in systemic candidiasis. J Infect Dis 181:2118.

Chin, J., B. Turner, I. Barchia, and A. Müllbacher. 2000. Immune response to orally consumed antigens and probiotic bacteria. Immunol Cell Biol 78:55.

Lee, E., and M. Lobigs. 2000. Substitutions at the putative receptor-binding site of an encephalitic flavivirus alter virulence and host cell tropism and reveal a role for glycosaminoglycans in entry. J Virol 74:8867.

Lee, E., K. McLean, R. C. Weir, and L. Dalgarno. 2000. Stimulation of dengue virus replication in cultured Aedes albopictus (C6/36) mosquito cells by the antifungal imidazoles ketoconazole and miconazole. Virology 269:1.

Lee, E., C. E. Stocks, S. M. Amberg, C. M. Rice, and M. Lobigs. 2000. Mutagenesis of the signal sequence of yellow fever virus prM protein: enhancement of signalase cleavage In vitro is lethal for virus production. J Virol 74:24.

Lobigs, M., G. Chelvanayagam, and A. Müllbacher. 2000. Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class I. Eur J Immunol 30:1496.

Mahalingam, S., P. S. Foster, M. Lobigs, J. M. Farber, and G. Karupiah. 2000. Interferon-inducible chemokines and immunity to poxvirus infections. Immunol Rev 177:127.

Riera, L., M. Gariglio, G. Valente, A. Müllbacher, C. Museteanu, S. Landolfo, and M. M. Simon. 2000. Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection. Eur J Immunol 30:1350.

Simon, M. M., P. Waring, M. Lobigs, A. Nil, T. Tran, R. T. Hla, S. Chin, and A. Müllbacher. 2000. Cytotoxic T cells specifically induce Fas on target cells, thereby facilitating exocytosis-independent induction of apoptosis. J Immunol 165:3663.

1999

Hayder, H., R. V. Blanden, H. Korner, D. S. Riminton, J. D. Sedgwick, and A. Müllbacher. 1999. Adenovirus-induced liver pathology is mediated through TNF receptors I and II but is independent of TNF or lymphotoxin. J Immunol 163:1516.

Lobigs, M., A. Müllbacher, R. V. Blanden, G. J. Hammerling, and F. Momburg. 1999. Antigen presentation in syrian hamster cells: substrate selectivity of TAP controlled by polymorphic residues in TAP1 and differential requirements for loading of H2 class I molecules. Immunogenetics 49:931.

Müllbacher, A., R. T. Hla, C. Museteanu, and M. M. Simon. 1999. Perforin is essential for control of ectromelia virus but not related poxviruses in mice. J Virol 73:1665.

Müllbacher, A., M. Lobigs, F. J. Kos, and R. Langman. 1999. Alloreactive cytotoxic T-cell function, peptide nonspecific. Scand J Immunol 49:563.

Müllbacher, A., M. Lobigs, J. W. Yewdell, J. R. Bennink, R. Tha Hla, and R. V. Blanden. 1999. High peptide affinity for MHC class I does not correlate with immunodominance. Scand J Immunol 50:420.

Müllbacher, A., M. Lobigs, J. W. Yewdell, J. R. Bennink, R. Tha Hla, and R. V. Blanden. 1999. Spontaneous mutation at position 114 in H-2Kd affects cytotoxic T cell responses to influenza virus infection. Eur J Immunol 29:1228.

Müllbacher, A., R. Wallich, R. W. Moyer, and M. M. Simon. 1999. Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections. J Immunol 162:7315.

Müllbacher, A., P. Waring, R. Tha Hla, T. Tran, S. Chin, T. Stehle, C. Museteanu, and M. M. Simon. 1999. Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc Natl Acad Sci U S A 96:13950.

Waring, P., and A. Müllbacher. 1999. Cell death induced by the Fas/Fas ligand pathway and its role in pathology. Immunol Cell Biol 77:312.

1998

Colombage, G., R. Hall, M. Pavy, and M. Lobigs. 1998. DNA-based and alphavirus-vectored immunisation with prM and E proteins elicits long-lived and protective immunity against the flavivirus, Murray Valley encephalitis virus. Virology 250:151.

San Gil, F., B. Turner, A. Müllbacher, M. J. Walker, S. P. Djordjevic, G. J. Eamens, and J. C. Chin. 1998. Flow cytometric analysis of cellular changes i