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Professor Chris Goodnow

Publications

2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | Before 1991

Book Chapters and Reviews

2008

  1. Heazlewood, C.K., Cook, M.C., Eri, R., Price, G.R., Tauro, S.B., Taupin, D., Thornton, D.J., Png, C.W., Crockford, T.L., Cornall, R.J., Adams, R., Kato, M., Nelms, K.A., Hong, N.A., Florin, T.H.J., Goodnow, C.C., and McGuckin, M.A., 2008, Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLOS Medicine 5(3), 440-460.
  2. Keys, J.R., Tallack, M.R., Zhan, Y., Papathanasiou, P., Goodnow, C.C., Gaensler, K.M., Crossley, M., Dekker, J., and Perkins, A.C., 2008, A mechanism for Ikaros regulation of human globin gene switching. British Journal of Haematology 141(3), 398-406.
  3. Liu, M., Duke, J.L., Richter, D.J., Vinuesa, C.G., Goodnow, C.C., Kleinstein, S.H., and Schatz, D.G., 2008, Two levels of protection for the B cell genome during somatic hypermutation. Nature 451(7180), 841-U11.
  4. Yu, D., Cook, M.C., Shin, D.M., Silva, D.G., Marshall, J., Toellner, K.M., Havran, W.L., Caroni, P., Cooke, M.P., Morse, H.C., MacLennan, I.C.M., Goodnow, C.C., and Vinuesa, C.G., 2008, Axon growth and guidance genes identify T-dependent germinal centre B cells. Immunology and Cell Biology 86(1), 3-14.

2007

  1. Goodnow, C.C., 2007, Nossal and Pike 1975: A turning point in the effort to define self-tolerance mechanisms. Journal of Immunology 179(9), 5617-5618.
  2. Goodnow, C.C., 2007, Multistep pathogenesis of autoimmune disease. Cell 130(1), 25-35.
  3. Goodnow, C.C., Campbell, J.A., Rui, L., and Vinuesa, C.G., 2007, Tolerance mechanisms in the late phase of the antibody response. Advances in Experimental Medicine and Biology 596, 163-168.
  4. Gosling, K.M., Makaroff, L.E., Theodoratos, A., Kim, Y.H., Whittle, B., Rui, L., Wu, H., Hong, N.A., Kennedy, G.C., Fritz, J.A., Yates, A.L., Goodnow, C.C., and Fahrer, A.M., 2007, A mutation in a chromosome condensin II subunit, kleisin {beta}, specifically disrupts T cell development. Proceedings of the National Academy of Sciences of the United States of America 104(30), 12445-12450.
  5. Horikawa, K., Martin, S.W., Pogue, S.L., Silver, K., Peng, K.M., Takatsu, K., and Goodnow, C., 2007, Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors. Journal of Experimental Medicine 204(4), 759-769.
  6. Li, G.C., Vega, R., Nelms, K., Gekakis, N., Goodnow, C., McNamara, P., Wu, H., Hong, N.A., and Glynne, R., 2007, A role for Alstrom syndrome protein, Alms1, in kidney ciliogenesis and cellular quiescence. PLoS Genetics 3(1), e8.
  7. Liston, A., Hardy, K., Pittelkow, Y., Wilson, S.R., Makaroff, L.E., Fahrer, A.M., and Goodnow, C.C., 2007, Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling. Genome Biology 8(1), R12.
  8. Liston, A., Siggs, O.M., and Goodnow, C.C., 2007, Tracing the action of IL-2 in tolerance to islet-specific antigen. Immunology and Cell Biology 85(4), 338-342.
  9. Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N.P., Crockford, T.L., Cabuy, E., Vindigni, A., Enver, T., Bell, J.I., Slijepcevic, P., Goodnow, C.C., Jeggo, P.A., and Cornall, R.J., 2007, DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447(7145), 686-U9.
  10. Siggs, O.M., Miosge, L.A., Yates, A.L., Kucharska, E.M., Sheahan, D., Brdicka, T., Weiss, A., Liston, A., and Goodnow, C.C., 2007, Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity 27(6), 912-926.
  11. Yu, D., Tan, A.H.-M., Hu, X., Athanasopoulos, V., Simpson, K.M., Silva, D., Hutloff, A., Giles, P.J., Leedman, K.P., Lam, N., Goodnow, C.C., and Vinuesa, C.G., 2007, Roquin represses autoimmunity by limiting inducible T cell costimulator messenger RNA. Nature 450(7167), 299-330.

2006

  1. Alexander, W.S., Viney, E.M., Zhang, J.G., Metcalf, D., Kauppi, M., Hyland, C.D., Carpinelli, M.R., Stevenson, W., Croker, B.A., Hilton, A.A., Ellis, S., Selan, C., Nandurkar, H.H., Goodnow, C.C., Kile, B.T., Nicola, N.A., Roberts, A.W., and Hilton, D.J., 2006, Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proceedings of the National Academy of Sciences of the United States of America 103(44), 16442-16447.
  2. Arsov, T., Larter, C.Z., Nolan, C.J., Petrovsky, N., Goodnow, C.C., Teoh, N.C., Yeh, M.M., and Farrell, G.C., 2006, Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biomedical and Biophysical Research Communications 342(4), 1152-1159.
  3. Blery, M., Tze, L., Miosge, L.A., Jun, J.E., and Goodnow, C.C., 2006, Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy. Journal of Experimental Medicine 203(7), 1773-1783.
  4. Cook, M.C., Vinuesa, C.G., and Goodnow, C.C., 2006, ENU-mutagenesis: insight into immune function and pathology. Current Opinion in Immunology 18(5), 627-633.
  5. Goodnow, C.C., 2006, Discriminating microbe from self suffers a double toll. Science 312(5780), 1606-1608
  6. Gray, D.H.D., Seach, N., Ueno, T., Milton, M.K., Liston, A., Lew, A.M., Goodnow, C.C., and Boyd, R.L., 2006, Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108(12), 3777-3785.
  7. Hoyne, G.F. and Goodnow, C.C., 2006, The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. Immunological Reviews 210, 27-39.
  8. Kennedy, C.L., O'Connor, A.E.O., Sanchez-Partida, L.G., Holland, M.K., Goodnow, C.C., de Kretser, D.M., and O'Bryan, M.K., 2006, A repository of ENU mutant mouse lines and their potential for male fertility research. Molecular Human Reproduction 11(12), 871-880.
  9. Manderson, A.P., Quah, B., Botto, M., Goodnow, C.C., Walport, M.J., and Parish, C.R., 2006, A novel mechanism for complement activation at the surface of B cells following antigen binding. Journal of Immunology 177(8), 5155-5162.
  10. Nijnik, A., Ferry, H., Lewis, G., Rapsomaniki, E., Leung, J.C.H., Daser, A., Lambe, T., Goodnow, C.C., and Cornall, R.J., 2006, Spontaneous B cell hyperactivity in autoimmune-prone MRL mice. International immunology 18(7), 1127-1137.
  11. Rui, L.X. and Goodnow, C.C., 2006, Lymphoma and the control of B cell growth and differentiation. Current Molecular Medicine 6(3), 291-308.
  12. Rui, L.X., Healy, J.I., Blasioli, J., and Goodnow, C.C., 2006, ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-Driven plasma cell differentiation. Journal of Immunology 177(8), 5337-5346.

2005

  1. Ferry, H., Cockford, T.L., Silver, K., Rust, N., Goodnow, C.C., and Cornall, R.J., 2005,
    Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival. European Journal of Immunology 35(12), 3655-3663.
  2. Goodnow, C.C., Sprent, J., de St Groth, B.F.,and Vinuesa, C.G.,
    Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature, 435, 590-597 (2005)
  3. Liston, A., Lesage, S., Gray, D.H.D., Boyd, R.L., and Goodnow, C.C., 2005, Genetic lesions in T-cell tolerance and thresholds for autoimmunity. Immunological Reviews 204, 87-101.
  4. Miosge, L. and Goodnow, C.C., 2005, Genes, pathways and checkpoints in lymphocyte development and homeostasis. Immunology and Cell Biology 83(4), 318-335.
  5. Papathanasiou, P. and Goodnow, C.C., 2005, Connecting Mammalian Genome with Phenome by ENU Mouse Mutagenesis: Gene Combinations Specifying the Immune System. Annual Review of Genetics 39, 241-262.
  6. Vinuesa, C.G., Cook, M.C., Angelucci, C., Athanasopoulos, V., Rui, L., Hill, K.M., Y, u, D., Domaschenz, H., Whittle, B., Lambe, T., Roberts, I.S., Copley, I.R., Bell, J.I., Cornall, R.J., and Goodnow, C.C., 2005, A novel RING-type ubiquitin ligase family member essential to repress follicular helper T cells and autoimmunity. Nature 435, 452-458.

2004

  1. Liston, A., Gray, D.H.D., Lesage, S., Fletcher, A.L., Wilson, J., Webster, K.E., Scott, H.S., Boyd, R.L., Peltonen, L., and Goodnow, C.C., 2004, Gene dosage-limiting role of Aire in thymic expression, clonal deletion and organ-specific autoimmunity. Journal of Experimental Medicine 200(8), 1015-1026.
  2. Liston, A., Lesage, S., Gray, D.H.D., O'Reilly, L.A., Strasser, A., Fahrer, A.M., Boyd, R.L., Wilson, J., Baxter, A.G., Gallo, E.M., Crabtree, G.R., Peng, K., Wilson, S.R., and Goodnow, C.C., 2004, Generalised resistance to thymic deletion in the NOD mouse: a polygenic trait characterized by defective induction of Bimí. Immunity 21(6), 817-830.
  3. Vinuesa, C.G. and Goodnow, C.C., 2004, Illuminating Autoimmune Regulators through Controlled Variation of the Mouse Genome Sequence. Immunity 20(6), 669-679.
2003
  1. Liston A, Lesage S, Wilson J, Peltonen L, Goodnow CC (2003). Aire regulates negative selection of organ-specific T cells. Nature Immunol 4, 350-354.
  2. Jun, J.E. and Goodnow, C.C., 2003, Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling. Nature Immunology 4(11), 1057-1064.
  3. Jun JE, Wilson LE, Vinuesa CG, Lesage S, Blery M, Miosge LA, Cook MC, Kucharska EM, Hara H, Penninger JM, Domashenz H, Hong NA, Glynne RJ, Nelms KA and Goodnow CC (2003). Identifying the MAGUK-protein Carma-1 as a central regulator of humoral immune responses and atopy by genome wide mouse mutagenesis. Immunity. 18(6), 751-762.
  4. Papathanasiou, P., Perkins, A.C., Cobb, B.S., Ferrini, R., Sridharan, R., Hoyne, G.F., Nelms, K.A., Smale, S.T., and Goodnow, C.C., 2003, Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity 19(1), 131-144.
  5. Rui L, Vinuesa CG, Blasioli J and Goodnow CC (2003). Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor-ERK signaling. Nature Immunology 4, 594-600.
  6. Socha, L., Silva, D., Lesage, S., Goodnow, C., and Petrovsky, N., 2003, The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.K iHEL, a novel model of beta cell death. Immunology of Diabetes II: Pathogenesis from Mouse to Man 1005, 178-183.
     

2002

  1. Lesage S, Hartley SB, Akkaraju S, Wilson J, Townsend M and Goodnow CG (2002) Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J Exp Med 196, 1175-88.
  2. Loy AL, Goodnow CC (2002) Novel approaches for identifying genes regulating lymphocyte development and function. Curr Opin Immunol 14, 260-265.
  3. Martin SW, Goodnow CC (2002) Burst-enhancing role of the IgG membrane tail as a
    molecular determinant of memory. Nat Immunol 3, 182-8.
  4. Miosge LA, Blasioli J, Blery M and Goodnow C (2002). Analysis of an ENU-generated mouse mutation defines a cell intrinsic role of NFkB2 in regulating circulating B cell numbers. J ExpMed 196, 1113-1119.
  5. Prasad SJ, Goodnow CC (2002) Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genes. Immunol Cell Biol 80, 198-206.

  6. Prasad SJ, Goodnow CC (2002) Cell-intrinsic effects of non-MHC NOD genes on dendritic
    cell generation in vivo. Int Immunol 14, 677-684.

  7. Vinuesa CG, Cook MC, Cooke MP, MacLennan ICM and Goodnow CC (2002). Analysis of B cell memory formation using DNA microarrays. Ann NY Acad Sci 975, 1-13.
  8. Vinuesa CG, Goodnow CC (2002) Immunology - DNA drives autoimmunity. Nature 416, 595.
     

2001

  1. Blasioli J and Goodnow CC (2001) Lyn/CD22/SHP-1 and their importance in autoimmunity. In Signal Transduction Pathways in Autoimmunity, ed Altman A. Reinhardt
    Druck, Basel. Vol 5, pp 151-160.
  2. Fahrer AM, Bazan JF, Papathanasiou P, Nelms KA and Goodnow CC (2001) A genomic view of immunology. Nature 409, 836-838.
  3. Goodnow CC (2001) Pathways for self-tolerance and the treatment of autoimmune diseases Lancet 357, 2115-2121.
  4. Goodnow CC, Glynne R, Akkaraju S, Rayner J, Mack D, Healy JI, Chaudhry S, Miosge L, Wilson L, Papathanasiou P, Loy A (2001) Autoimmunity, self-tolerance and immune homeostasis: From whole animal phenotypes to molecular pathways Adv Exp Med Biol 490, 33-40.
  5. Lesage S, Goodnow CC (2001) Organ-specific autoimmune disease: A deficiency of tolerogenic stimulation. J Exp Med 194, F31-F36.
  6. Nadeau JH, Balling R, Barsh G, Beier D, Brown SDM, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, de Angelis MH, Jackson I, Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka AM, Rinchik EM, Rossant J, Russell LB, Schimenti J, Shiroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS, Wurst W, Zimmer A (2001) Sequence interpretation - Functional annotation of mouse genome sequences Science 291, 1251-1255.
  7. Nelms KA, Goodnow CC (2001) Genome-wide ENU mutagenesis to reveal immune regulators. Immunity 15, 409-418.
  8. Townsend SE, Goodnow C, Cornall RJ (2001) Single epitope multiple staining to detect ultralow frequency B cells. Journal of Immunological Methods 249, 137-146.
     
2000
 
  1. Cornall, R.J., Cheng, A.M., Pawson, T. & Goodnow, C.C. (2000) Role of Syk in B cell development and antigen-receptor signalling Proc Natl Acad Sci U S A. 97, 1713-1718.
  2. Glynne RJ, Ghandour G, Goodnow CC. (2000). Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy. Curr Opin Immunol. 12, 210-214.
  3. Glynne, R, Ghandour, G., Rayner, J., Mack, D. & Goodnow, C.C. (2000). B lymphocyte quiescence, tolerance, and activation as viewed by global gene expression profiling on microarrays. Immunol Rev 176: 216-46.

  4. Glynne, R., Akkaraju, S., Healy, J.I., Rayner, J., Goodnow, C.C. & Mack, D. (2000) How self-tolerance and the immunosuppressive drug FK506 prevent B cell mitogenesis. Nature 403:, 72-676.

  5. Martin S and Goodnow CC (2000) Immunology: Memory needs no reminders. Nature 407, 576-577.

  6. Pogue SL & Goodnow CC (2000) Gene dose-dependent maturation and receptor editing of B cells expressing IgG1 or IgM/IgG1-tail antigen receptors. J Exp Med 191, 1031-1044.

  7. Weintraub BC, Jun JE, Bishop AC, Shokat KM & Goodnow CC (2000). Entry of B cell receptor into signalling domains is inhibited in tolerant B cells. J. Exp. Med 191, 1443-1448.
     
1999
 
  1. Cornall RJ, Goodnow CC, Cyster JG (1999). Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway. Curr Top Microbiol Immunol 244, 57-68.

  2. Goodnow CC, Glynne R, Mack D, Weintraub B, Rathmell J, Healy JI, Chaudhry S, Miosge L, Loy A and Wilson L (1999) Mechanisms of self-tolerance and autoimmunity: from whole animal phenotypes to molecular pathways. Cold Spring Harbor Laboratory Symposia on Quantitative Biology 64:,313-322.

  3. Townsend SE, Weintraub BC and Goodnow CC (1999) Growing up on the streets, why B cell development differs from T cell development. Immunology Today 20, 217-220.
     

1998

 

  1. Cornall, R.J. and Goodnow, C.C (1998) ell antigen receptor signalling in the balance of tolerance and immunity. Novartis Found Symposium 215, 21-30.


  2. Cornall, R.J., Cyster, J.G., Hibbs, M.L., Dunn, A.R., Otipoby, K.L., Clark, E.A. and Goodnow, C.C.(1998) Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8, 497-508.

  3. Fang, W., Weintraub, B.C., Dunlap, B., Garside, P., Pape, K.A., Jenkins, M.K., Goodnow, C.C., Mueller, D.L. and Behrens, T.W.(1998) Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity 9, 35-45.

  4. Fischer, M.B., Goerg, S., Shen, L., Prodeus, A.P., Goodnow, C.C., Kelsoe, G. and Carroll, M.C.(1998): Dependence of germinal center B cells on expression of CD21/CD35 for survival. Science 280, 582-585.

  5. Goodnow, C.C.(1998) er immunotherapy: new leads on an elusive goal. Medical Journal of Australia 169, 570-571.

  6. Goodnow, C.C (1998) d genes, new lifestyles and future medicines. Australasian Science 19, ii, pp41-42.

  7. Healy, J.I. and Goodnow, C.C.(1998) Positive versus negative signaling by lymphocyte antigen receptors. Annual Review of Immunology. 16, 645-670.

  8. Healy, J.I., Dolmetsch, R.E., Lewis, R.S., Goodnow, C.C. (1998). Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes. Novartis Found Symposium 215, 137-144.

  9. Prodeus, AP., Goerg S, Shen, LM., Pozdnyakova, OO., Chu, L., Alicot, E.M., Goodnow, C.C. and Carroll, M.C.(1998) . A critical role for complement in maintenance of self-tolerance. Immunity 9, 721-731.

  10. Rathmell, J.C. and Goodnow, C.C.(1998) The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their microenvironment. Immunology and Cell Biology 76, 387-394.

  11. Rathmell, J.C., Fournier, S., Weintraub, B.C., Allison, J.P. and Goodnow, C.C.(1998): Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and alllow Fas-mediated deletion by CD4+ T cells. Journal of Experimental Medicine 188, 651-659.

  12. Schmidt, K., Hsu, C., Griffin, C.T., Goodnow, C.C. and Cyster J.G.(1998) Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor wild-type B cells. Journal of Experimental Medicine 187, 929-937.

  13. Townsend, S.E. and Goodnow, C.C.(1998) Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo. Journal of Experimental Medicine 187, 1611-1621.

  14. Weintraub, B.C. and Goodnow, C.C. (1998) Immune Responses: costimulatory receptors have their say. Current Biology Biol 8, 575-577.

  15. Ying, H., Healy, J.I, Goodnow, C.C. and Parnes, J.R.(1998) Regulation of mouse CD72 gene expression during B lymphocyte development. Journal of Immunology 161, 4760-4767.
     
1997
 
  1. Akkaraju, S., Ho, W.Y., Leong, D., Canaan, K., Davis, M.M. & Goodnow, C.C. (1997)   "Range of CD4 T cell tolerance: partial inactivation to organ-specific antigens allows thyroiditis or insulitis without tissue destruction". Immunity, 7, 255-271.

  2. Akkaraju, S., Canaan, K. & Goodnow, C.C. (1997)  "Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells". J. Exp. Med., 186, 2005-2012.

  3. Dolmetsch, R.E., Lewis, R.S., Goodnow, C.C. & Healy, J.I. (1997)  "Differential activation of transcription factors induced by Ca2+ response amplitude and duration". Nature, 386, 855-858.

  4. Fournier, S., Rathmell, J.C., Goodnow, C.C. & Allison, J.P. (1997)  "T cell-mediated elimination of B7.2 transgenic B cells". Immunity, 6, 327-339.

  5. Healy, J.I., Dolmetsch, R.E., Timmerman, L.A., Cyster, J.G., Thomas, M.L., Crabtree, G.R., Lewis, R.S. & Goodnow, C.C. (1997)  "Different nuclear signals are activated by the B cell receptor during positive versus negative signaling". Immunity, 6, 419-428.

  6. Inaoki, M., Sato, S., Weintraub, B.C., Goodnow, C.C. & Tedder, T.F. (1997)  "CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes". J. Exp. Med., 186, 1923-1931.

  7. Macaulay, A.E., DeKruyff, R.H., Goodnow, C.C. & Umetsu, D.T. (1997)  "Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4". J. Immunol., 158, 4171-4179.

  8. Timmerman, L.A., Healy, J.I., Ho, S.N., Chen, L., Goodnow, C.C. & Crabtree, G.R. (1997)  "Redundant expression but selective utilization of nuclear factor of activated T cells family members". J. Immunol., 159, 2735-2740.
     
1996
 
  1. Cyster, J.G., Healy, J.I., Kishihara, K., Mak, T.W., Thomas, M.L., & Goodnow, C.C. (1996)  "Regulation of B lymphocyte negative and positive selection by tyrosine phosphatase CD45" Nature, 381, 325-328.

  2. Dempsey, P.W., Allison, M.E.D., Akkaraju, S., Goodnow, C.C. & Fearon, D.T. (1996)  "C3d of complement as a molecular adjuvant: bridging innate and acquired immunity". Science, 271, 348-350.

  3. Liblau, R.S., Tisch, R., Shokat, K., Yang, X., Dumont, N., Goodnow, C.C. & McDevitt, H.O. (1996)  "Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis." Proc. Natl. Acad. Sci. USA, 93, 3031-3036.

  4. Rathmell, J.C., Townsend, S.E., Xu, JC, Flavell, R.A. & Goodnow, C.C. (1996)  "Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor". Cell, 87, 319-329.
     

1995

 

  1. Brink, R., Goodnow, C.C. & Basten, A. (1995)  "IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up-regulation CD80/CD86 co-stimulatory molecules". Eur. J. Immunol., 25, 1980-1984.

  2. Cyster, J.G. & Goodnow, C.C. (1995)  "Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection". Immunity, 2, 13-24.

  3. Cyster, J.G. & Goodnow, C.C. (1995)  "Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords". J. Exp. Med., 182, 581-586.

  4. Cyster, J.G. & Goodnow, C.C. (1995)  "Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate". Immunity, 3, 691-701.

  5. Lund, F.E., Solvason, N.W., Cooke, M.P., Heath, A.W., Grimaldi, J.C., Parkhouse, R.M.E., Goodnow, C.C. & Howard, M.C. (1995)  "Signaling through murine CD38 is impaired in antigen receptor unresponsive B cells". Eur. J. Immunol., 25, 1338-1345.

  6. Rathmell, J.C., Cooke, M.P., Ho, W.Y., Grein, J., Townsend, S.E., Davis, M.M. & Goodnow, C.C. (1995)  "CD95 (Fas/APO-1)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells". Nature, 376, 181-184.

  7. Shokat, K.M. & Goodnow, C.C. (1995)  "Antigen-induced B cell death and elimination during germinal center immune responses". Nature, 375, 334-338.
     

1994

 

  1. Bell, S.E. & Goodnow, C.C. (1994)  "A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes". EMBO J., 13, 816-826.

  2. Brink, R., Fulcher, D.A., Goodnow, C.C. & Basten, A. (1994)  "Differential regulation of early and late stages of B lymphocyte development by the m and d heavy chains of Ig". Int. Immunol., 6, 1905-1916.

  3. Cooke, M.P., Heath, A.W., Shokat, K.M., Zeng, Y., Finkelman, F.D., Linsley, P.S., Howard, M. & Goodnow, C.C. (1994)  "Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells" J. Exp. Med., 179, 425-438.

  4. Cyster, J.G., Hartley, S.B. & Goodnow C.C. (1994)  "Competition for follicular niches excludes self-reactive cells from the recirculating B cell repertoire". Nature, 371, 389-395.

  5. Hartley, S.B. & Goodnow, C.C. (1994)  "Censoring of self-reactive B cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antibody". Int. Immunol., 9, 1417-1425.

  6. Ho, W.Y., Cooke, M.P., Goodnow, C.C. & Davis, M.M. (1994)  "Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells". J. Exp Med., 179, 1539-1549.

  7. Lenschow, D.J., Sperling, A.I., Cooke, M.P., Freeman, G., Rhee, L., Decker, D.C., Gray, G., Nadler, L.M., Goodnow, C.C. & Bluestone, J.A. (1994)  "Differential upregulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement". J. Immunol., 153, 1990-1997.

  8. Pogue, S.L. & Goodnow, C.C. (1994)  "The immunoglobulin heavy chain extracellular spacer confers unique glycosylation of the Mb-1 component of the B cell antigen receptor". J. Immunol., 152, 3925-3934.

  9. Rathmell, J. & Goodnow, C.C. (1994)  "Effects of the lpr mutation on elimination and inactivation of self-reactive B cells". J. Immunol., 153, 2831-2842.

1993

 

  1. Hartley, S.B., Cooke, M.P., Fulcher, D.A., Harris, A.W., Cory, S., Basten, A. & Goodnow, C.C. (1993)  "Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death". Cell, 72, 325-335.

1992

 

  1. Brink, R., Goodnow, C.C., Crosbie, J., Adams, E., Eris, J., Mason, D.Y., Hartley, S.B. & Basten, A. (1992)  "IgM and IgD antigen receptors are both capable of mediating B lymphocyte activation, deletion or anergy following interaction with specific antigen". J. Exp. Med., 176, 991-1005.

  2. Mason, D. Y., Jones, M. & Goodnow, C.C. (1992)  "Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD-transgenic mice". International Immunol., 4, 163-175.

1991

 

  1. Adelstein, S., Briscoe, H., Anderson, T.A., Crosbie, J., Gammon, G., Loblay, R.H., Basten, A. & Goodnow, C.C. (1991)  "Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen". Science, 251, 1223-1225.

  2. Brooks, A., Hartley, S., Kjer-Nielsen, L., Perera, J., Goodnow, C.C., Basten, A. & McCluskey, J. (1991)  "Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme". Proc. Natl. Acad. Sci. U.S.A., 88, 3290-3294.

  3. Hartley, S.B., Crosbie, J., Brink, R., Kantor, A.B., Basten, A. & Goodnow, C.C. (1991)  "Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens". Nature, 353, 765-769.

  4. Goodnow, C. C., Brink, R. & Adams, E. (1991)  "Breakdown of self-tolerance in anergic B lymphocytes". Nature, 352, 532-536.

1990

  1. Adams, E., Basten, A. & Goodnow, C.C. (1990)  "Intrinsic B cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice". Proc. Natl. Acad. Sci. U.S.A., 87, 5687-5691.


  2. Goodnow, C.C., Crosbie, J., Jorgensen, H., Brink, R.A. & Basten, A. (1989)  "Induction of self-tolerance in mature peripheral B lymphocytes". Nature., 342, 385-391.

  3. Berg, L.J., Fazekas de St Groth, B., Ivars, F., Goodnow, C.C., Gilfillan, S., Garchon, H-J. & Davis, M.M. (1988)  "Expression of T-cell receptor alpha chain genes in transgenic mice" Mol. Cell. Biol., 8, 5459-5469.

  4. Goodnow, C.C., Crosbie, J., Adelstein, S., Lavoie, T.B., Smith-Gill, S.J., Brink, R.A., Pritchard-Briscoe, H., Wotherspoon, J.W., Loblay, R.H., Raphael, K., Trent, R.J. & Basten, A. (1988)  "Altered immunoglobulin expression and functional silencing of self-reactive B-lymphocytes in transgenic mice" Nature, 334, 676-682.

  5. Gascoigne, N.R.J., Goodnow, C.C., Dudzik, K.I., Oi, V.T. & Davis, M.M. (1987)  "Secretion of a chimeric T-cell receptor-immunoglobulin protein" Proc. Natl. Acad. Sci. USA., 84, 2936-2940.

  6. Gascoigne, N.R.J., Waters, S., Elliot, J.F., Victor-Kobrin, C., Goodnow, C.C., Davis, M.M. & Bona, C.A. (1986)  "Expression of T-cell receptor genes in an antigen-specific hybridoma and radiation-induced variants" J. Exp. Med., 164, 113-130.


  7. Becker, D.M., Patten, P., Chien, Y-H., Yokota, T., Eshhar, Z., Giedlin, M., Goodnow, C.C., Wolf, R., Arai, K-I. & Davis, M.M. (1985)  "Variability and repertoire size of T-cell receptor Va gene segments"  Nature, 317, 430-434.

  8. Goodnow, C.C. & Raison, R.L. (1985)  "Structural analysis of the myeloma-associated antigen KMA"  J. Immunol., 135, 1276-1280.

  9. Walker, K.Z., Hayden, G.E., Goodnow, C.C., Boux, H.A., Adams, E., Basten, A. & Raison, R.L. (1985)  "Coexpression of an epitope on human free k-light chains and on a cytoplasmic component in activated T-cells" J. Immunol., 134, 1059-1064.



Book Chapters and Review Articles

1985

1. Walker, K.Z., Boux, H.A., Hayden, G.E., Goodnow, C.C., & Raison, R.L. (1985)  "A monoclonal antibody with selectivity for human kappa myeloma and lymphoma cells which has potential as a therapeutic agent" In Microenvironments in the Lymphoid System (ed Klaus, G.G.B., Plenum Press, NY), pp 833-841.

1986

2. Davis, M.M., Lindsten, T., Gascoigne, N.R.J., Goodnow, C.C. & Chien, Y-H (1986)  "T-cell receptor gene structure and function" Cell. Immunol., 99, 24-28.

3. Davis, M.M., Lindsten, T., Gascoigne, N.R.J., Goodnow, C.C. & Chien, Y-H (1986)  "Paradigm regained: similarities and differences between T-cell receptor and immunoglobulin genes" Biochem. Soc. Symp., 51, 205-209.

4. Davis, M.M., Goodnow, C.C., Gascoigne, N.R.J., Lindsten, T. & Chien, Y-H (1986)  "Murine T-cell receptor genes and the problems of cellular recognition and repertoire selection" In Regulation of Immune Gene Expression (eds Feldmann, M. & McMichael, A., Humana Press, Clifton, NJ), pp 137-142.

1988

5. Ivars, F., Berg, L.J., Fazekas de St Groth, B., Goodnow, C.C., Garchon, H-J., Gilfillan, S. & Davis, M.M. (1988)  "Expression of T-cell receptor a-chain genes in transgenic mice" In The T-cell Receptor (eds. Kappler, J. & Davis, M.M., Alan R. Liss, NY), pp187-197.

1989

6. Goodnow, C.C., Crosbie, J., Adelstein, S., Lavoie, T.B., Smith-Gill, S.J., Brink, R.A., Pritchard-Briscoe, H., Wotherspoon, J.W., Loblay, R.H., Raphael, K., Trent, R.J. & Basten, A. (1989)  "Immunological tolerance in lysozyme/ anti-lysozyme transgenic mice." in The Immune Response to Structurally Defined Proteins: The Lysozyme Model (eds. S. Smith-Gill and E. Sercarz, Adenine Press, New York), pp 389-402.

7. Goodnow, C.C. & Basten, A. (1989)  "Self-tolerance in B lymphocytes". Sem. Immunol., 1, 125-135.

8. Goodnow, C.C. (1989)  "Cellular mechanisms of self-tolerance". Curr. Opinion in Immunol., 2, 226-236.

1990

9. Goodnow, C.C., Crosbie, J., Adelstein, S., Lavoie, T.B., Smith-Gill, S.J., Mason, D.Y., Jorgensen, H., Brink, R.A., Pritchard-Briscoe, H., Loughnan, M., Loblay, R.H., Trent, R.J. & Basten, A. (1990)  "Clonal silencing of self-reactive B lymphocytes in a transgenic mouse model". Cold Spring Harbor Symp. Quant. Biol., 54, 907-920.

10. Arnold, B., Goodnow, C.C., Hengartner, H. & Hammerling, G. (1990)  "The coming of transgenic mice: tolerance and immune reactivity". Immunology Today, 11, 69-72.

11. Goodnow, C.C., Adelstein, S. & Basten, A. (1990)  "The need for central and peripheral tolerance in the B cell repertoire". Science, 248, 1373-1379.

1991

12. Basten, A., Brink, R., Peake, P., Adams, E., Crosbie, J., Hartley, S. & Goodnow, C.C. (1991)  "Self-tolerance in the B cell repertoire". Immunol. Rev., 122, 5-19.

1992

13. Goodnow, C. C. (1992)  "Transgenic mice and analysis of B cell tolerance". Ann. Rev. Immunol., 10, 489-518.

14. Goodnow, C.C. (1992)  "Safe havens for self-reactive cells". Curr. Biol., 2, 417-419.

15. Goodnow, C.C. (1992)  "B cell tolerance". Curr. Opin. Immunol., 4, 703-710.

1993

16. Goodnow, C.C., Mason, D.Y., Jones, M., & Adams, E. (1993)  "Tolerant autoreactive B lymphocytes in the follicular mantle zone compartment: substrates for receptor editing and reform." In Molecular Mechanisms of Immunological Self-Recognition, eds H. Vogel and F. Alt, Academic Press, N.Y., pp 25-36.

1994

17. Hartley, S.B. & Goodnow, C.C. (1994)  "Manipulation of transgene-encoded self antigens to explore mechanisms of B cell tolerance". In Analysis of the Immune System Utilizing Transgenesis and Targeted Mutagenesis, eds Ohashi, P. and Bluthmann, H., Academic Press, New York. pp 227-249.

1995

18. Goodnow, C.C., Cyster, J.G., Hartley, S.B., Bell, S.E., Cooke, M.P., Healy, J.I., Akkaraju, S., Rathmell, J.C., Pogue, S.L. & Shokat, K.M. (1995)  "Self-tolerance checkpoints in B lymphocyte development". Adv. Immunol., 59, 279-368.

19. Cornall, R.J., Goodnow, C.C. & Cyster, J.G. (1995)  "The regulation of self-reactive B cells". Current Opinion in Immunology, 7, 804-811.

20. Rathmell, J.C. & Goodnow, C.C. (1995)  "The Fas Track". Curr. Biology, 5, 1218-1221.

1996

21. Goodnow, C.C. (1996)  "Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires". Proc. Natl. Acad. Sci. USA., 93, 2264-2271.

22. Janeway, C.A. Jr, Goodnow C.C., & Medzhitov, R. (1996)  "Danger - pathogen on the premises! Immunological tolerance". Current Biology, 6, 519-22.

23. Goodnow, C.C. (1996)  "Balancing immunity, autoimmunity and self tolerance in B lymphocytes". In Immune Tolerance, eds J. Banchereau, B. Dodet, E. Trannoy, Elsevier, Paris, pp73-83.

1997

24. Goodnow, C.C. (1997)  "Glimpses into the balance between immunity and self-tolerance." In The Molecular Basis of Cellular Defence Mechanisms, Eds G.R. Bock and J.A. Goode, John Wiley & Sons, Chichester, pp190-202.

25. Goodnow, C.C. & Cyster, J.G. (1997)  "Lymphocyte migration: the scent of a follicle". Current Biology, 7, 219-222.

26. Goodnow, C.C. (1997)  "Chance encounters and organized rendezvous". Immunol. Rev., 156, 5-10.

27. Goodnow, C.C. (1997)  "Balancing immunity, autoimmunity, and self-tolerance". Ann. N.Y. Acad. Sci., 815, 55-66.

28. Cyster, J.G. & Goodnow, C.C. (1997)  "Tuning antigen receptor signaling by CD22: Integrating cues from antigens and the microenvironment". Immunity, 6, 509-517.

29. Liston, A. and Goodnow, C.C., 2005, Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity. Genetics of Autoimmunity, eds. G. Bock and J. Goode, Chichester, UK: John Wiley and Sons Ltd. pp. 180-199.

 
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