Publications
2008
Liu, M., Duke, J.L., Richter, D.J., Vinuesa, C.G., Goodnow,
C.C., Kleinstein, S.H., and Schatz, D.G., 2008, Two levels of protection for
the B cell genome during somatic hypermutation. Nature 451(7180), 841-U11.
Rigby, R.J. and Vinuesa, C.G., 2008, SiLEncing SLE: the power
and promise of small noncoding RNAs. current Opinion in Rheumatology 20(5),
526-531.
Yu, D., Cook, M.C., Shin, D.M., Silva, D.G., Marshall, J., Toellner, K.M., Havran,
W.L., Caroni, P., Cooke, M.P., Morse, H.C., MacLennan, I.C.M., Goodnow, C.C.,
and Vinuesa, C.G., 2008, Axon growth and guidance genes identify
T-dependent germinal centre B cells. Immunology and Cell Biology 86(1), 3-14.
2007
D. Yu, A. H-M. Tan, X. Hu, V. Athanasopoulos, Simpson, K. M., D. Silva, A.
Hutloff, Giles, P.J. Leedman, K.P. Lam, N., C.C. Goodnow and C.G. Vinuesa.
Roquin represses autoimmunity by limiting inducible T cell costimulator messenger
RNA. Nature. 2007. 450, 299-303.
Goodnow CC, Campbell JA, Rui L and Vinuesa CG. Tolerance mechanisms
in the late phase of the antibody response. Adv Exp Med Biol. 2007; 596:163-8.
Vinuesa CG, Cook MC. Genetic analysis of systemic autoimmunity.
Novartis Found Symp. 2007; 281:103-20; discussion 120-8, 208-9.
Vinuesa, CG and Cook, MC. The molecular basis of lymphoid architecture
in the mouse. In: The mouse in Biomedical Research. Publisher: Academic Pr;
2nd edition. ISBN: 012369454X
2006
Cook, M.C., C.G. Vinuesa, and C.C. Goodnow. ENU-mutagenesis:
insight into immune function and pathology. Curr Opin Immunol. 2006. 18:627-633.
Jayasekera, J.P., C.G. Vinuesa, G. Karupiah, and N.J. King.
Enhanced antiviral antibody secretion and attenuated immunopathology during
influenza virus infection in nitric oxide synthase-2-deficient mice. J Gen Virol.
2006. 87:3361-3371.
Arsov T, Silva GD, O’Bryan KM, Sainsbury A, Lee JN, Kennedy C, Manji,
MS, Nelms K, Liu C, Vinuesa CG, de Kretser MD, Goodnow CC and
Petrovsky N. (2006) Fat Aussie: a new Alstrom syndrome mouse showing a critical
role for ALMS1 in obesity, diabetes and spermatogenesis. Mol Endocrinol. 20(7):1610-22.
Hsu, M-C, Toellner, K-M, Vinuesa, C.G. and MacLennan, ICM.
B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular
antibody responses. 2006 Proc Natl Acad Sci, 103(15):5905-10.
2005
Vinuesa, C.G., Tangye, S., Moser, B., Mackay, C. T follicular
helper cells and antibody responses. Nature Rev. Immunol. 5, 2005 Nov;5(11):853-65.
Vinuesa C. Immunol Cell Biol. Book review. 2005 Oct;83(5):584
M. Linterman and C.G. Vinuesa. Roquin: a novel immune regulator
that represses ICOS expression and differentiation of self-reactive T cells.
Inmunologia, 2005. 24, 326-333.
Goodnow, CC., Sprent, J., Fazekas de St Groth, B., & Vinuesa, C.G.
Cellular and genetic mechanisms of self-tolerance and autoimmunity. Nature,
435, 7042, 2005.
Vinuesa, C.G., Cook, M.C., Angelucci, C., Athanasopoulos, V.,
Rui, L., Hill, K.M., Yu, D., Domaschenz, H., Whittle, B., Lambe, T., Roberts,
I.S., Copley, I.R., Bell, J.I., Cornall, R.J., and Goodnow, C.C. A novel RING-type
ubiquitin ligase family member essential to repress follicular helper T cells
and autoimmunity. 2005. Nature 435, 452-458, 2005.
2004
Vinuesa CG, Goodnow CC. Illuminating autoimmune regulators
through controlled variation of the mouse genome sequence. Immunity. 2004 20:669-79.
2003
MacLennan IC, Toellner KM, Cunningham AF, Serre K, Sze DM, Zuniga E, Cook MC
and Vinuesa, CG. Extrafollicular antibody responses. Immunol.
Rev. 194:8-18, 2003.
Jun JE, Wilson LE, Vinuesa CG, Lesage S, Blery M, Miosge LA,
Cook MC, Kucharska EM, Hara H, Penninger JM, Domashenz H, Hong NA, Glynne RJ,
Nelms KA, Goodnow CC. Identifying the MAGUK protein Carma-1 as a central regulator
of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity.
18:751-62, 2003.
Rui, L., Vinuesa, C.G. Blasioli, J. and Goodnow, C.C. Resistance
to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor
ERK signaling. Nature Immunol. 4:594-600, 2003.
Vinuesa, C.G., Sze, D.M-Y., Cook, M.C., Toellner, K-M., Klaus,
G.G.B. Ball, J., and MacLennan, I.C.M. Recirculating and germinal center B cells
differentiate into cells responsive to polysaccharide-antigens. Eur. J. Immunol.
33, 297-305, 2003.
2002
Vinuesa, C.G., Cook, M.C., Cooke, M.P., MacLennan, I.C.M.
and Goodnow C.C. Analysis of B cell memory formation using DNA microarrays.
Ann N. Y. Acad. Sci. 975, 33-45, 2002.
MacLennan, I.C.M and Vinuesa C.G. Dendritic cell-derived BAFF
and APRIL: innate players in adaptive antibody responses. Immunity, 17:235-238.
2002.
Vinuesa, C.G. and Goodnow, C.C. DNA drives autoimmunity. Nature, 2002.
416, 595-598.
Toellner KM, Jenkinson WE, Taylor DR, Khan M, Sze DM, Sansom DM, Vinuesa
C.G., MacLennan IC. Low-level Hypermutation in T Cell-independent Germinal
Centers Compared with High Mutation Rates Associated with T Cell-dependent Germinal
Centers. J. Exp. Med. 2002. 195:383-9.
2001
Vinuesa C.G. and Cook MC. The molecular basis of lymphoid
architecture and B cell responses: Implications for immunodeficiency and immunopathology.
Curr. Molec. Med. 2001. 1: 689-725.
Vinuesa C.G., de Lucas C, Cook MC. Clinical implications of
the specialised B cell response to polysaccharide encapsulated pathogens. Postgrad.
Med. J. 2001. 77:562-9.
Vinuesa C.G., Sunners Y, Pongracz J, Ball J, Toellner KM, Taylor
D, MacLennan IC, Cook MC. Tracking the response of Xid B cells in vivo: TI-2
antigen induces migration and proliferation but Btk is essential for terminal
differentiation. Eur. J. Immunol. 31:1340-50. 2001.
2000
Sze, D.M-Y., Toellner, K-M., Vinuesa, C.G., Taylor, D.R.,
and MacLennan I.C.M. Intrinsic constraint on plasmablast growth and extrinsic
limits of plasma cell survival. 2000. J.Exp.Med. 192: 813-822.
Vinuesa, C.G., Cook, M., Ball, J., Drew, M., Sunners, Y., Klaus, G.G.B.,
Cascalho, M., Wabl, M. MacLennan, I.C.M. Germinal centres without T cells. 2000.
J. Exp. Med. 191:485-493.
MacLennan, I.C.M., Vinuesa, C.G., Casamayor-Palleja, M. B cell
memory and the persistence of antibody responses. Phil. Trans. R. Soc. Lond.
B. 2000. 355, 345-350.
1999
Vinuesa, C.G., Gulbranson-Judge, A., Khan, M., O’Leary,
P., Cascalho, M., Wabl, M., Klaus, G.G.B., Owen, M.J., MacLennan, I.C.M. Dendritic
cells associated with plasmablast survival. 1999. Eur. J. Immunol. 29, 3712-3721.
Vinuesa, C.G., MacLennan, I.C.M. Holman, M., and Klaus G.B.
Anti-CD40 antibody enhances responses to polysaccharide without mimicking T
cell help. 1999. Eur. J. Immunol. 29, 3216-322.
Vinuesa, C.G., O’Leary, P., Sze, D.M-Y., Toellner, K-M.,
MacLennan I.C.M. TI-2 antigens induce B cell proliferation in multiple splenic
sites, but exponential growth is confined to extrafollicular foci. 1999. Eur.
J. Immunol. 29, 1314-1327.
