Transcriptional networks controlling mammary development and breast cancer phenotype

Friday 13 July 2012

Clustering breast cancers by their transcriptome into ‘molecular subtypes’ identifies a number of groups with unique histopathology and clinical behaviour. These distinct patterns of gene expression are the product of gene expression networks controlled by transcription factors, epigenetic modifications and RNA regulatory molecules such as microRNAs. In this presentation, I will describe recent data from our lab identifying transcriptional regulators controlling lineage commitment during breast development, breastcancer malignancy and therapeutic responsiveness.

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