Congratulations to JCSMR PhD student Ms Christine Lee, who has been awarded an Outstanding Young Scholar Travel Fellowship from the Asian-Pacific Society on Thrombosis and Hemostasis (APSTH) and Japanese Society on Thrombosis and Hemostasis (JSTH) to attend the 2017 APSTH-JSTH joint symposium in Nagoya, Japan in June. There she will give an oral presentation on "Elevated plasma soluble GPVI (sGPVI) levels as a marker of platelet-activating autoantibodies in heparin-induced thrombocytopenia (HIT)".
HIT is a drug-induced, autoimmune disorder with potentially fatal outcomes. It occurs in 1 to 5% of patients exposed to heparin. Identifying patients at risk of developing HIT remains clinically challenging because not all patients with detectable HIT antibody develop HIT. We propose that patient sGPVI levels may help identify a platelet-activating HIT antibody. We found that considering sGPVI levels in addition to current HIT diagnostic tools improved specificity and overall accuracy of HIT diagnosis.
Christine is undertaking her PhD in the The Gardiner Group - Cancer-related Vascular Disorders in the ACRF Department of Cancer Biology and Therapeutics at JCSMR with Associate Professor Elizabeth Gardiner.