Dr Alexei Tulin is an Associate Professor and Laboratory Head in the Epigenetics and Progenitor Cell Program at the Fox Chase Cancer Center, Philadelphia, PA, USA. Dr Tulin discovered the role of Poly(ADP-ribose) Polymerase 1 (PARP1) in chromatin and transcriptional regulation during his PhD and postdoc. Poly(ADP-ribose), a nucleic acid assembled by PARP1, is the third most common nucleic acid, superseded in its importance only ye the well-known DNA and RNA. Dr Tulin found that PARP1 controls transcription profile of a cell by assembling polymers of Poly(ADP-ribose) and hence loosening chromatin at specific loci.
His research covers four major areas of PARP1 biology: 1) molecular mechanisms of PARP1 localization and regulation; 2) role of PARP1 in chromatin regulation, epigenetic bookmarking and its genomic targets of PARP1; 3) regulation of pADPr pathway by Poly(ADP-ribose)glycohydrolase (PARG); 4) clinical applications of PARP1 regulation. Dr Tulin’s research has been supported by two NIH RO1 grants and an award from the Elison Medical Foundation. Recently, his lab has launched a new project on using PARP1 as a target for cancer treatment. Building upon his discoveries, Dr Tulin is designing highly specific PARP1 inhibitors for cancer treatment by targeting histone mediated rout of PARP1 activation.