Associate Professor Maija Kohonen-Corish, Cancer Institute NSW Career Development Fellow, Head, Colon Cancer Genetics & Biology Group, Garvan Institute of Medical Research.
Professor Kohonen-Corish will talk about the rediscovery of the 'Mutated in Colorectal Cancer' (MCC) as a candidate tumour suppressor gene in colon cancer. MCC is emerging as a multifunctional factor affecting several cellular pathways and her laboratory has led the study of the biological functions of MCC. Another major area of recent research is the development of a new mouse model of colon cancer. The NSAID sulindac triggers a pathway in the mouse large intestine that may be informative for understanding the genetic basis of sporadic colon cancer.
Associate Professor Kohonen-Corish is a Group Leader at the Garvan Institute of Medical Research and the Kinghorn Cancer Centre in Sydney. She has a 21-year track record of discovery in cancer research, including the genetic basis of colon cancer, translational research in colon and lung cancer and the development of mouse models of cancer. She completed her PhD in the Department of Human Genetics at The John Curtin School of Medical Research in 1988, followed up by a Postdoc in the Department of Microbiology. Subsequently, she established a new cancer genetics laboratory (1991-2000) at The John Curtin School with Professor Bill Doe. This laboratory was one of the first in Australia to identify the inherited gene mutations that predispose to hereditary nonpolyposis colon cancer (Lynch Syndrome). Since 2002, she has built up a competitive new research group at the Garvan Institute.