Professor Oliver Mühlemann, PhD, Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
Professor Mühlemann's scientific interests revolve around post-transcriptional gene regulation mechanisms. Extensive alternative splicing and polyadenylation of primary transcripts increases not only the genetic potential of mammalian cells but also the frequency of producing nonsense transcripts. A main focus of his lab is to unravel the molecular underpinnings of nonsense-mediated mRNA decay (NMD) and to understand how and based on which features cells select substrates for the NMD pathway. With the discovery that NMD plays a role beyond mRNA surveillance as a translation-dependent regulator of gene expression, they also started to investigate in which biological functions NMD plays an important role. In addition to their NMD research, they also began to explore the role of disease-associated RNA-binding proteins in the respective disease pathomechanism (e.g. the role of FUS in ALS).