Dr Daniela Stock, Laboratory Head, Structural and Computational Biology Division, Victor Chang Cardiac Research.
We are using X-ray crystallography to determine the structure of proteins and protein complexes at high resolution. Currently we focus on studying the structure and function of protein complexes that contain molecular rotary motors such as vacuolar ATPases and the flagellar motor. Both complexes are involved in proton translocation through membranes and we are investigating the overall architecture of the proton channels, the molecular mechanisms of proton translocation and the generation of rotation. By comparing two very different systems, we are hoping to uncover some of the general principles of biological rotary motors.