Professor Jose Villadangos, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC.
In this talk I will present our recent work describing intracellular mechanisms that control the capacity of dendritic cells to detect pathogens and present antigens to T cells, the first event of the acquired immune response. I will also show how dendritic cells interpret signals received from the extracellular environment to adapt their function to current and past pathogen encounters.
José Villadangos is a Professor in the Department of Microbiology and Immunology (Peter Doherty Institute) and the Department of Biochemistry and Molecular Biology (Bio21 Institute) of The University of Melbourne, Australia. He obtained his Ph. D. from the Universidad Autónoma de Madrid (Spain) and trained as a post-doc in the laboratories of Hidde Ploegh (Massachusetts Institute of Technology and Harvard Medical School, Boston) and Ken Shortman (The Walter and Eliza Hall Institute, Melbourne). He established his own laboratory at The Walter and Eliza Hall Institute in 2001 and moved to The University of Melbourne in 2011.
José has authored over 100 original articles, reviews and book chapters. He has received funding from the Human Frontiers Science Program, the Leukemia and Lymphoma Society, the National Health and Medical Research Council of Australia and the Australian Research Council. José is the Editor-in-Chief of Molecular Immunology and President of the International Congress of Immunology 2016 to be held in Melbourne.
The current research interests of Prof. Villadangos include: (i) Mechanisms of antigen presentation; (ii) The development and regulation of dendritic cell functions; (ii) Regulation of membrane proteostasis by ubiquitination; (iii) Adoptive T cell therapy against cancer; (iv) Formation of tissue-resident CD8 T cell memory.