Professor Georges E. R. Grau, Chair of Vascular Immunology, Department of Pathology, Sydney Medical School, The University of Sydney.
Professor Georges Grau obtained a MD from the University of Liège and a Privat-Docent from the University of Genève. He has been the Chair of Vascular Immunology at the University of Sydney since 2006. Since 1979, his research has focused on immunopathological mechanisms of infectious diseases, and since 1985 more specifically on cerebral malaria.
His in vivo intervention studies in murine models contributed to the elucidation of cytokine interactions leading to tissue injury, with particular attention to tumour necrosis factor (TNF), which had important implications for cell adhesion molecules in various models of pathology. In multi-compartment co-culture systems involving human cells, his group found that platelets can act as effectors of cytokine-induced microvascular endothelial damage. His team also demonstrated that membrane microparticles, released by several cell types, profoundly alter endothelial integrity and thereby can be crucial elements in immunopathology. His 293 papers (215 peer-reviewed) have been cited over 16,000 times and his h-index is 61.
Current projects at the Vascular Immunology Unit deal with pathophysiological events at the level of brain microvascular endothelium. They aim at defining new pathogenic mechanisms, in order to propose new therapeutic avenues in inflammation.