Dr Axel Kallies, Molecular Immunology, Walter and Eliza Hall Institute.
Our lab is interested in understanding the molecular events that regulate late lymphocyte differentiation. This process is central to the immune system as it generates the effector populations that determine the ability of our body to control pathogens such as HIV or plasmodium (malaria) and to generate protective immunity after vaccination.
However, the process of lymphocyte differentiation is also intimately linked to autoimmune pathology and leukaemia development. Thus, a thorough understanding of the key molecules involved the peripheral differentiation of B and T cells, the main lymphocytic lineages, is central to any therapeutic approach aimed at treating immunodeficiencies, blood cell-derived cancers or autoimmunity.
Our lab utilises a number of transgenic and knock-out mouse models such as green fluorescent protein (GFP)-based transcription factor reporter mice as well as infection models such as influenza and lymphocytic choriomeningitis virus (LCMV). We are utilising a broad range of molecular techniques including next-generation sequencing, microarrays, real-time PCR and chromatin immunoprecipitation (ChIP).