JCSMR School Seminar Series - Lymphoma mutations – Joining the dark side

Dr Keisuke Horikawa, ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, ANU

Signalling from antigen receptors plays a crucial role in determining the fate of normal lymphocytes. How about malignant lymphocytes, lymphomas? Do they need antigenic stimulation through the B cell receptor for survival or proliferation? My team is addressing this long-standing question using retrovirus gene delivery of lymphoma-associated mutations and self-reactive B cell model. Investigating the consequence of oncogenic mutations in CARD11 and MYD88 revealed that growth and survival of malignant B cells are not as autonomous as previously thought. Our study provides new insights into pathogenesis and potential therapeutic targets for lymphomas.

Date & time

12–1pm 18 November 2016


The Finkel Lecture Theatre, The John Curtin School of Medical Research, Building 131 Garran Road, ANU


Host: Professor Ross Hannan


 Jeanette Mill
 +61 2 6125 3732

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