JCSMR School Seminar Series - Liquid Biopsies: Monitoring the Cancer Genome in Blood

Dr Sarah-Jane Dawson, Molecular Biomarkers and Translational Genomics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC

Cell-free circulating DNA containing tumor-specific sequences can be identified in the plasma of cancer patients, providing a liquid biopsy alternative to tissue biopsies for monitoring cancer genetic changes over time.  Circulating tumor DNA (ctDNA) analysis can allow real-time monitoring of tumor dynamics and treatment response from a simple blood test that is safe, reliable and easy to perform at regular intervals during therapy. Serial analysis of ctDNA provides a unique opportunity to study the evolving genomic landscape of a cancer during therapy, identify the early emergence of treatment resistance and guide targeted therapeutic decisions.  The use of ctDNA for molecular disease monitoring has enormous potential to facilitate precision medicine and optimize cancer management across a range of malignancies.  A summary of current approaches for ctDNA analysis will be presented, together with an overview of clinical applications for the use of liquid biopsies in cancer management. 

Date & time

12–1pm 5 August 2016


The Finkel Lecture Theatre, The John Curtin School of Medical Research, Building 131 Garran Road, ANU


Host: Professor Ross Hannan


 Emma Dowling
 +61 2 6125 2572

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