JCSMR School Seminar Series - Infection-Induced Tertiary Germinal Centres

Dr Michelle Linterman, Group Leader, Lymphocyte Signalling and Development, The Babraham Institute, UK

Germinal centres are highly organised structures that form in secondary lymphoid tissues after infection or immunisation, resulting in the production of long-lived antibody secreting plasma cells and memory B cells, which provide protection against subsequent infection. Germinal centre-like structures can form in non-lymphoid tissues following infection, but the requirements for their formation and function are not well characterised: Particularly how peripheral tissues are remodelled by infection to facilitate the recruitment of lymphocytes, and establish de novo a stromal cell network that supports tertiary germinal centres. This seminar will focus on how influenza-induced lung germinal centres are formed, and whether these structures follow the same rules as their counterparts in secondary lymphoid tissues.

Date & time

12–1pm 3 March 2017


The Finkel Lecture Theatre, The John Curtin School of Medical Research, Building 131 Garran Road, ANU


Host: Professor Carola Vinuesa


 Doris Morales
 +61 2 6125 4996

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