Professor Paul A Gleeson, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC
The Golgi apparatus is a highly dynamic organelle at the heart of the secretory pathway and a variety of diseases and disorders are associated with a perturbation in the architecture and function of the Golgi. In protists, plants and invertebrates, individual Golgi stacks are scattered throughout the cytoplasm of the cell, whereas vertebrates have evolved mechanisms for joining the Golgi stacks into a ribbon, typically found in a juxtanuclear location in interphase cells. However, the relevance of the “ribbon” structure of the Golgi in vertebrates has remained a mystery. My laboratory has developed a system to explore the function of the Golgi ribbon. I will discuss strategy use to manipulate the Golgi ribbon structure and present our findings that the Golgi ribbon regulates mTOR signalling and autophagy. The importance of these findings in relation to in a number of pathogenic conditions, including neurodegeneration, will be highlighted.