Dr Amardeep Dhillon, Oncogenic Signalling and Growth Control Program Research Division, Peter MacCallum Cancer Centre.
The small GTP-binding protein KRAS and the protein kinase BRAF are activators of an evolutionarily conserved signal transduction pathway that controls cell proliferation, survival, differentiation and motility. Mutations in KRAS and BRAF generate two of the most common human oncogenes, critical for the development and progression of many types of cancer.
Our research aims to unravel key transcriptional effectors of oncogenic KRAS and BRAF signalling, and understand how they contribute to activation of pro-malignant gene expression programs. In this talk, I will describe how these oncoproteins engage the transcription factor AP-1 to disrupt epithelial differentiation and promote tumour cell proliferation, migration, invasion and survival. I will also discuss our efforts to understand how AP-1 function is regulated in cancer cells through use of interactome-based analysis.