Department of Cancer Biology and Therapeutics & Department of Genome Sciences Combined Seminar Series -Roles of histone variant H3.3 and ATRX in tumorigenesis

Dr Lee Wong, Monash University.

Dr Lee Wong is a group leader at Monash University, Australia. Her long-standing research interest is to identify new chromatin factors that control chromosome stability and genetic transmission. In particular, her team aims to uncover basic epigenetic mechanisms that regulate centromere and telomere function. Recent studies have identified the frequent mutations of histone variant H3.3 and its chaperone ATRX in human cancers, especially, in telomerase null cancers that use an ALT (Alternative Lengthening of telomeres) for telomere elongation. Their current projects aim to define the function of histone variant H3.3 and ATRX in controlling transcription silencing at the telomeres and in the global genome. They also investigate genome-wide epigenetic defects associated with H3.3 mutations and the loss of ATRX function in human cancers.


Date & time

3.30–4.30am 25 May 2017


Seminar Rooms 1 and 2, Level 3, The John Curtin School of Medical Research, Building 131 Garran Road, ANU


 Dr Nadine Hein

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