Professor Marc Jenkins, University of Minnesota.
Naive lymphocytes are formed by random processes without foreign antigens. The cells with relevant antigen receptors are then selected into the immune response after a foreign antigen enters the body. The diversity of lymphocytes with different antigen receptors within a polyclonal repertoire, however, has made it difficult to study the rare cells that are specific for a given foreign antigen. This lecture will contain a description of how antigen-based enrichment methods can be used to detect naive antigen-specific lymphocytes and follow their differentiation into effector and memory cells following exposure to antigen in the body. These studies show that antigen-specific naive cell populations vary in size in ways that can influence the magnitude and quality of the immune response.
Dr Jenkins received his PhD in Microbiology and Immunology in 1985 from Northwestern University and then conducted postdoctoral training in the Laboratory of Immunology at the National Institutes of Health. He joined the Microbiology Department at the University of Minnesota in 1988 and the Center for Immunology in 1995. Dr Jenkins has received the Pew Scholar in the Biomedical Sciences Award, the American Association of Immunologists Meritorious Career Award, and an NIH Merit Award. He serves as a Councilor for The American Association of Immunologists and will be President of this organization in 2014.