Listen to Professor Ross Hannan' recent radio interview: Curing cancer - Are we close?
As head of the Cancer Therapeutics Group Professor Ross Hannan's work focuses on the molecular analysis of major pro-malignant transcription factor networks that operate in cancer cells using an integrated approach that combines cell biology, genomics, proteomics, biochemistry, genetics, bioinformatics and strong interactions with oncologists in the clinic. Through this molecular understanding, he hopes to identify key therapeutic nodes to impede the progression of aggressive cancers. The availability of ribosomes is a fundamental rate-limiting step for tumour cell proliferation. He is examining the genetic and epigenetic processes by which ribosomal RNA gene transcription, is regulated by RNA Polymerase I, and how this process is dysregulated during cancer.
Professor Hannan and his group has progressed this fundamental research a step closer to treating patients and changing clinical practice. His group developed the world’s first selective inhibitors of Pol I transcription (Bywater et al. Cancer Cell 2012; Bywater et al., Nature Reviews Cancer 2013), which are a new class of therapeutic. This inhibitor is currently in Phase I clinical trials at Peter Mac for the treatment of haematological malignancies. His lab is also involved in the development of second generation drugs and evaluating their efficiency in other cancers such as ovarian and prostate.
A second area of research focus for Professor Hannan is ribosomopathies, a group of inherited diseases including Diamond Blackfan Anaemia (DBA) and myelodysplastic (5q-) syndrome. Such patients are also predisposed to developing haematological malignancies such as acute myeloid leukemia (AML). Ribosomopathies are caused by dysregulated ribosome biogenesis. Thus understanding the mechanisms mediating these diseases may identify novel approaches for their treatment, which at this time is palliative only.
Professor Hannan’s group has utilized genome wide and chemical screening to identify potential candidates, which underlie the genetic and/or functional cause of various ribosomopathies. Expanding from this understanding the mechanisms underlying the increased predisposition for patients with ribosomopathies to develop cancers such as AML is also being evaluated.
Organisational unit member
Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP and Jung SM (2017) Receptor clustering as a mechanism to regulate GPVI signalling in platelets. Journal of Thrombosis and Haemostasis (2017) in press.
Devlin, JR, Hannan, KM, Hein, N, Cullinane, C, Kusnadi, E, Ng, PY, George, AJ, Shortt, J, Bywater, MJ, Poortinga, G, Sanij, E, Kang, J, Drygin, D, O'Brien, S, Johnstone, RW, McArthur, GA, Hannan RD and Pearson, RB (2016) Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma. Cancer Discovery 6(1):59-70
Guo L, Zaysteva O, Nie Z, Mitchell NC, Er J, Lee A, Ware T, Parsons L, Luwor R, Poortinga G, Hannan RD, Levens DL and Quinn LM (2016) Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the Mediator Complex to modulate MYC transcription and tissue growth. Nucleic Acid Research 44(16):7646-58
Kang J, Kusnardi EP, Ogden A, Hicks RJ, Bammert L, Kutay U, Hung S, Sanij E, Hannan RD, Hannan KM and Pearson RB (2016) Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription Oncotarget 7(31):48887-48904
Quin J, Chan KT, Devlin JR, Cameron DP, Diesch J, Cullinane C, Ahern J, Khot A, Hein N, George AJ, Hannan KM, Poortinga G, Sheppard KE, Khanna KK, Johnstone RW, Drygin D, McArthur GA, Pearson RB, Sanij E and Hannan RD (2016) Inhibition of RNA Polymerase transcription initiation activates non-canonical ATM/ATR signaling. Oncotarget 7(31): 49800-49818
Chan KT, Paavolainen L, Hannan KM, George AJ, Hannan RD, Simpson KJ, Horvath P and Pearson RB (2016) Whole-Genome RNAi screening and phenotypic classification analysis to identify regulators of oncogene-Induced senescence. Assay and Drug Development Technologies 14(7): 416-428
Rebello RJ, Kusnadi E, Cameron D, Pearson H, Lesmana A, Devlin J, Drygin D, Clark AK, Porter L, Pedersen J, Sandhu S, Risbridger GP, Pearson RB, Hannan RD and Furic L (2016) The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer. Clinical Cancer Research 22(22):5539-5552