Our group discovers molecular and cellular mechanisms and genes regulating the immune response, either:
- to prevent autoimmunity against self antigens (eg lupus, diabetes, rheumatoid arthritis, thyroiditis);
- to prevent uncontrolled growth of lymphoid malignancies (leukemia, lymphoma and myeloma);
- or to promote immunity and immunological memory against viruses and bacteria (immunization and immunological memory).
We aim to answer central questions about the mechanisms of tolerance and immunity in B and T cells, and to create a collaborative environment where the next generation of scientific leaders can establish independent lines of research while drawing upon shared expertise and resources. To achieve these aims, we develop and use state-of-the-art methods from mouse and human molecular genetics and genomics, biochemistry and cell biology, cell signalling, cellular immunology and clinical immunology.
Members of our group pursue exciting research problems that break new ground conceptually and clinically, and learn a broad range of methods and concepts from across the fields of modern genomics and immunology.